9月
PSI-697；化合物 T16676P-Selectin Inhibitor；P-Selectin Inhibitor (2024/9/1)
简介：psi-697 is an inhibitor of oral p-selectin (ic50: 125 μm).
Pseudouridine；假尿苷Pseudouridine (2024/9/1)
简介：pseudouridine is the most abundant modified nucleoside in non-coding rnas. it enhances the function of transfer rna and ribosomal rna by stabilizing rna structure.
Pseudouridimycin；化合物 T16673PUM；PUM (2024/9/1)
简介：pseudouridimycin is a c-nucleoside analogue. pseudouridimycin is an antibiotic and is a selective bacterial rna polymerase (rnap) inhibitor. it is effective against both gram-negative and gram-positive bacteria.
PSB-1114 tetrasodium；化合物 T16672PSB-1114 tetrasodium (2024/9/1)
简介：psb-1114 tetrasodium shows >50-fold selectivity versus the p2y4 (ec50: 9.3 μm) and p2y6 (ec50: 7.0 μm) receptors. psb-1114 tetrasodium is an effective, enzymatically stable, and subtype-selective p2y2 receptor agonist (ec50: 134 nm) .
PS315；化合物 T16671PS315 (2024/9/1)
简介：ps315 inhibits the full-length and catalytic domain constructs of pkcζ (ic50=10 μm) and pkcη (ic50=30 μm). ps315 has anti-cancer activity. ps315 is a derivative of ps48 and is an allosteric pkc inhibitor by binding to the pif-pocket of apkc and inducing displacement of the active site residue lys111.
PS210；化合物PS210PS210 (2024/9/1)
简介：ps210 is a potent and selective activator of pdk1 (kd: 3 μm), specifically targeting the pif-binding pocket of pdk1, without acting against other protein kinases such as s6k, pkb/akt, or gsk3. its prodrug, ps423, serves as a substrate-selective inhibitor of pdk1 in cells, inhibiting the phosphorylation and activation of s6k.
Tandutinib；坦度替尼MLN518|||CT53518|||NSC726292；MLN518|||CT53518|||NSC726292|||坦度替尼 (2024/9/1)
简介：tandutinib (ct53518) (mln518, ct53518), an effective flt3 antagonist (ic50: 0.22 μm), can also inhibit c-kit and pdgfr, 15-20 fold higher potency for flt3 versus csf-1r and >100-fold selectivity for the same target versus fgfr, egfr, and kdr.
Fludrocortisone；氟氢可的松9α-fluorocortisol|||9α-Fludrocortisone|||Florinef|||9α-fluorohydrocortisone|||F (2024/9/1)
简介：fludrocortisone (florinef) is a synthetic corticosteroid with moderate glucocorticoid potency and much greater mineralocorticoid potency. fludrocortisone can be used to studies on treating low blood pressure.
PRX-08066；化合物PRX-08066PRX-08066 (2024/9/1)
简介：prx-08066 is a selective 5-hydroxytryptamine receptor 2b (5-ht2br, ic50= 3.4 nm) antagonist that induces selective vasodilation of pulmonary arteries.
PROTO-1；化合物 T16668PROTO-1 (2024/9/1)
简介：proto-1 displays obviously protection of hair cells, with hc50(concentration that would produce 50% hair cell survival) of 1 μm-10 μm (1 μm≤hc50≤10 μm).
PROTAC Sirt2 Degrader-1；化合物 T16667PROTAC Sirt2 Degrader-1 (2024/9/1)
简介：protac sirt2 degrader-1 is a sirreal-based protac, acts as a sirt2 degrader, composed of a highly potent and isotype-selective sirt2 inhibitor, a linker, and a bona fide cereblon ligand for e3 ubiquitin ligase. protac sirt2 degrader-1 shows an ic50 of 0.25 μm for sirt2, with no effect on sirt1/sirt3 (ic50s > 100 μm)[1].
NH2-PEG3-C1-Boc化合物 T16666PROTAC Linker 5 (2024/9/1)
简介：nh2-peg3-c1-boc, also known as protac linker 5, is a polyethylene glycol (peg)-based linker utilized in the synthesis of proteolysis targeting chimeras (protacs)[1].
Triethylene glycol；化合物 T16665PROTAC Linker 25；PROTAC Linker 25 (2024/9/1)
简介：triethylene glycol (protac linker 25) is a polyethylene glycol (peg) derivative commonly employed as a linker in the synthesis of proteolysis targeting chimeras (protacs)[1].
N3-PEG4-C2-NH2化合物 T16664PROTAC Linker 20 (2024/9/1)
简介：n3-peg4-c2-nh2 (protac linker 20) is a peg-based linker compound utilized for the synthesis of protacs. its chemical structure enables efficient conjugation and serves as a bridging element between the target protein and the e3 ligase, facilitating targeted protein degradation[1].
Bis-NH2-PEG2；化合物 T16663PROTAC Linker 19；PROTAC Linker 19 (2024/9/1)
简介：bis-nh2-peg2 (protac linker 19) is a peg-based linker compound utilized for the synthesis of protacs.
Tetraethylene glycol三缩四乙二醇PROTAC Linker 18|||三缩四乙二醇 (2024/9/1)
简介：tetraethylene glycol (protac linker 18) is a polyethylene glycol (peg)-based linker that finds utility in the synthesis of protacs[1].
NH2-PEG5-C2-NH-Boc；化合物 T16661PROTAC Linker 17；PROTAC Linker 17 (2024/9/1)
简介：nh2-peg5-c2-nh-boc (protac linker 17) is a peg-based compound utilized as a linker in the synthesis of protacs[1].
N3-PEG3-CH2COOH；化合物 T16660N-3-PEG3-CH2COOH|||N3 PEG3 CH2COOH|||PROTAC Linker 14|||N3-PEG3-CH2COOH||| (2024/9/1)
简介：n3-peg3-ch2cooh (protac linker 14) is a peg-based compound utilized for the synthesis of protacs.
Fludrocortisone acetate；醋酸氟氢可的松9α-Fluorcortisol acetate|||9α-Fludrocortisone acetate|||9α-fluorocort (2024/9/1)
简介：fludrocortisone acetate (9α-fludrocortisone acetate) , a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase a2 (pla2). fludrocortisone acetate is the acetate salt of a synthetic fluorinated corticosteroid with anti-inflammatory and antiallergic activities. inhibition of pla2 activity prevents the release of arachidonic acid, a pre
Boc-NH-PEG2-C2-NH2；化合物 T16659PROTAC Linker 13；PROTAC Linker 13 (2024/9/1)
简介：boc-nh-peg2-c2-nh2 (protac linker 13) is a peg-based linker utilized for the synthesis of protacs. this chemical compound plays a crucial role in connecting the targeted protein and the e3 ubiquitin ligase for selective protein degradation[1].
Boc-NH-PEG4；化合物 T16658PROTAC Linker 12；PROTAC Linker 12 (2024/9/1)
简介：boc-nh-peg4, also known as protac linker 12, is a peg-based linker compound utilized for the synthesis of protacs[1].
Boc-NH-PEG2化合物 T16657PROTAC Linker 11 (2024/9/1)
简介：boc-nh-peg2 (protac linker 11) is a polyethylene glycol (peg)-based linker that finds application in the synthesis of protacs. [1]
Propynol Ethoxylate；化合物 T16656Propynol Ethoxylate (2024/9/1)
简介：propynol ethoxylate is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Propargyl-PEG9-OH；化合物 T16655Propargyl-PEG9-OH (2024/9/1)
简介：propargyl-peg9-oh is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Propargyl-PEG9-bromide；化合物 T16654Propargyl-PEG9-bromide (2024/9/1)
简介：propargyl-peg9-bromide is a non-cleavable adc linker used in the synthesis of antibody-drug conjugates (adcs)[1].
Propargyl-PEG9-amine；化合物 T16653Propargyl-PEG9-amine (2024/9/1)
简介：propargyl-peg9-amine is a peg-based protac linker can be used in the synthesis of protacs.
Propargyl-PEG8-OH；化合物 T16652Propargyl-PEG8-OH (2024/9/1)
简介：propargyl-peg8-oh is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Propargyl-PEG8-NH2；化合物 T16651Propargyl-PEG8-NH2 (2024/9/1)
简介：propargyl-peg8-nh2 (compound 3b) is a non-cleavable adc linker used in the synthesis of antibody-drug conjugates (adcs)[1].
Propargyl-PEG8-bromide；化合物 T16650Propargyl-PEG8-bromide (2024/9/1)
简介：propargyl-peg8-bromide is a non-cleavable adc linker used in the synthesis of antibody-drug conjugates (adcs)[1].
Daptomycin；达托霉素LY146032；达托霉素|||LY146032 (2024/9/1)
简介：daptomycin (ly146032) is a cyclic lipopeptide antibiotic that inhibits gram-positive bacteria.
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