9月
BMS-193885；化合物BMS-193885BMS-193885 (2024/9/1)
简介：bms-193885 is a selective, brain-penetrant, and competitive antagonist of the neuropeptide y1 receptor with a ki of 3.3 nm, and an ic50 of 5.9 nm for hy1.
BMS-1166 hydrochloride；化合物 T14670BMS-1166 hydrochloride (2024/9/1)
简介：motixafortide (bkt140 4-fluorobenzoyl) is an antagonist of cxcr4 (ic50: 1 nm). bms-1166 hydrochloride is an inhibitor of pd-1/pd-l1 interaction (ic50: 1.4 nm). bms-1166 rivalries the inhibitory effect of pd-1/pd-l1 immune checkpoint on t cell activation.
Acemetacin阿西美辛阿西美辛|||K-708|||TVX 1322 (2024/9/1)
简介：acemetacin (tvx 1322) is a carboxymethyl ester of indometacin. it is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin. in clinical trials, acemetacin exhibits a better gastric tolerability compared to its active metabolite indometacin.
Difloxacin HCl；化合物 T1466LDifloxacin HCl (2024/9/1)
简介：difloxacin is a second-generation, synthetic fluoroquinolone antimicrobial antibiotic.
BMS-066；化合物 T14669BMS-066 (2024/9/1)
简介：bms-066 is an ikkβ/tyk2 pseudokinase inhibitor. with ic50s of 9 nm and 72 nm, respectively.
BMPS；化合物 T14668BMPS (2024/9/1)
简介：bmps, a non-cleavable adc linker, is utilized in the synthesis of antibody-drug conjugates (adcs).
BLT-1；化合物BLT-1BLT-1 (2024/9/1)
简介：blt-1 is a scavenger receptor bi (sr-bi)inhibitor.
BL-1249；化合物BL-1249BL-1249 (2024/9/1)
简介：bl-1249 is a selective and potent non-steroidal potassium channel activator with anti-inflammatory activity that activates k2p2.1 (trek-1) and k2p10.1 (trek-2).
Motixafortide TFA(664334-36-5,Free)；化合物Motixafortide TFATF 14016 TFA|||BKT140 TFA|||BL-8040 TFA|||T1 (2024/9/1)
简介：motixafortide tfa(664334-36-5,free) (bkt140 tfa) is an antagonist of cxcr4 with ic50 of ～1 nm. it induces the apoptosis of aml blasts by down-regulating erk, bcl-2, mcl-1 and cyclin-d1 via altered mir-15a/16-1 expression.
Motixafortide化合物 T14665BL-8040|||BKT140 (4-fluorobenzoyl)|||TF14016 (2024/9/1)
简介：motixafortide (bkt140 4-fluorobenzoyl) is an antagonist of cxcr4 (ic50: 1 nm).
BI 689648；化合物 T14664BI 689648 (2024/9/1)
简介：bi 689648 is a highly selective inhibitor of aldosterone synthase(cyp11b1 and cyp11b2 with ic50s of 310 and 2.1 nm, respectively).
Bis-Tos-(2-hydroxyethyl disulfide)；化合物 T14663Bis-Tos-(2-hydroxyethyl disulfide) (2024/9/1)
简介：bis-tos-(2-hydroxyethyl disulfide) is a cleavable linker employed in the synthesis of antibody-drug conjugates (adcs)[1].
Bis-propargyl-PEG9；化合物 T14662Bis-propargyl-PEG9 (2024/9/1)
简介：bis-propargyl-peg9 is a peg-based protac linker employed in the synthesis of protacs. it is specifically utilized to synthesize the bivalent ligands of estrogen receptor[1].
Bis-propargyl-PEG8；化合物 T14661Bis-propargyl-PEG8 (2024/9/1)
简介：bis-propargyl-peg8 (compound 16e) is a polyethylene glycol (peg)-based linker that is employed in the synthesis of proteolysis targeting chimeras (protacs).
Bis-propargyl-PEG7；化合物 T14660Bis-propargyl-PEG7 (2024/9/1)
简介：bis-propargyl-peg7 is a polyethylene glycol (peg)-based linker utilized in the synthesis of proteolysis targeting chimeras (protacs). it is particularly employed for the synthesis of polymer-linked multimers of guanosine-3´,5´-cyclic monophosphates[1].
Nadifloxacin；那氟沙星OPC7251；OPC7251|||那氟沙星 (2024/9/1)
简介：nadifloxacin (opc7251) has been used in trials studying the treatment of acne vulgaris.
Bis-propargyl-PEG6；化合物 T14659Bis-propargyl-PEG6 (2024/9/1)
简介：bis-propargyl-peg6 is a polyethylene glycol (peg) derivative commonly employed as a peg-based protac linker during the synthesis of protacs. its application includes the generation of polymer-linked multimers of guanosine-3´, 5´-cyclic monophosphates[1].
Bis-propargyl-PEG5；化合物 T14658Bis-propargyl-PEG5 (2024/9/1)
简介：bis-propargyl-peg5 serves as a peg-based protac linker, facilitating the synthesis of protacs. this chemical compound is particularly employed in the synthesis of carbohydrate receptors (scrs) with anti-zika activity[1].
Bis-propargyl-PEG4；化合物 T14657Bis-propargyl-PEG4 (2024/9/1)
简介：bis-propargyl-peg4 is a peg-based protac linker utilized in protac synthesis and specifically employed in the synthesis of demethylvancomycin dimers[1][2].
Bis-propargyl-PEG3；化合物 T14656Bis-propargyl-PEG3 (2024/9/1)
简介：bis-propargyl-peg3 is a peg-based protac linker utilized for the synthesis of protacs. it is also employed in the synthesis of antiplasmodial zinc-dipicolylamine (zndpa) complexes[1] [2].
Bis-propargyl-PEG2；化合物 T14655Bis-propargyl-PEG2 (2024/9/1)
简介：bis-propargyl-peg2, a peg-based protac linker, facilitates the synthesis of protacs and demethylvancomycin dimers[1][2].
Bis-propargyl-PEG12；化合物 T14654Bis-propargyl-PEG12 (2024/9/1)
简介：bis-propargyl-peg12 is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Bis-propargyl-PEG1；化合物 T14653Bis-propargyl-PEG1 (2024/9/1)
简介：bis-propargyl-peg1 is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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