9月
Quarfloxin；化合物QuarfloxinCX-3543；CX-3543 (2024/9/1)
简介：quarfloxin (cx-3543) is a fluoroquinolone derivative with antineoplastic activity with ic50 values in the nanomolar range in neuroblastoma cells. quarfloxin disrupts the interaction between the nucleolin protein and a g-quadruplex dna structure in the ribosomal dna template.
QL47；化合物QL47QL47 (2024/9/1)
简介：ql47 is a host-targeted small molecule antiviral agent with antiviral activity against dengue and other rna viruses.ql47 acts as an inhibitor of viral translation and a covalent inhibitor of btk, and can be used in the study of lymphomas.
QCA570；化合物 T16701QCA570 (2024/9/1)
简介：qca570 is an effective bet degrader based on protac (ic50: 10 nm for brd4 bd1 protein).
QC6352化合物 T16700QC 6352|||QC6352|||QC-6352 (2024/9/1)
简介：qc6352 is a selective and effective kdm4c inhibitor (ic50: 35 nm).
Lanatoside C毛花甙丙Cedilanid|||Ceglunate|||Isolanid|||毛花甙丙|||毛花苷C (2024/9/1)
简介：lanatoside c (ceglunate) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). lanatoside c can be used orally or by the intravenous route.
Liothyronine HCl；化合物 T1669LTriiodothyronine|||L-T3|||NSC 80203|||Liothyronine|||Liotironina|||L-Liot (2024/9/1)
简介：liothyronine is a t3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine.
PYZD-4409；化合物PYZD-4409PYZD-4409 (2024/9/1)
简介：pyzd-4409 is a selective uba1 inhibitor with an ic50 of 20 μm. pyzd-4409 induces cell death in malignant cells and is preferentially cytotoxic to malignant cells over normal hematopoietic cells.
Pyronin Y；派洛宁YC.I. 45005|||Pyronine G；C.I. 45005|||派洛宁Y|||派洛宁 Y|||Pyronine G (2024/9/1)
简介：pyronin y (pyronine g) is an intercalating cationic dye that shows specificity towards rna.
Pyronaridine tetraphosphate；磷酸咯萘啶Pyronaridine tetraphosphate (2024/9/1)
简介：pyronaridine tetraphosphate is an orally active, mannitol-containing inhibitor of dna topoisomerase 2 and erythrocyte cytokine with antimalarial and antitumour activity.pyronaridine tetraphosphate treats p. falciparum and echinococcus granulosus infections. pyronaridine tetraphosphate treats p. falciparum and echinococcus granulosus infections and attenuates ebola virus transmission.
Pyriproxyfen；吡丙醚S-31183；S-31183|||吡丙醚 (2024/9/1)
简介：pyriproxyfen (s-31183) is an insecticide that acts as a biomimetic of juvenile hormone.
Pyrintegrin；化合物 PyrintegrinPyrintegrin (2024/9/1)
简介：pyrintegrin is an β1-integrin agonist that promotes embryonic stem cells´ survival. pyrintegrin can be used as a podocyte-protective agent. pyrintegrin enhances cell-extracellular matrix adhesion-mediated integrin signaling.
Pyridoclax；化合物 T16694MR-29072；MR-29072 (2024/9/1)
简介：pyridoclax is an inhibitor of potential mcl-1.
Pyrene-PEG5-alcohol；化合物 T16693Pyrene-PEG5-alcohol (2024/9/1)
简介：pyrene-peg5-alcohol is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Pyrene-amido-PEG4-CH2CH2COOH；化合物 T16692Pyrene-amido-PEG4-CH2CH2COOH (2024/9/1)
简介：pyrene-amido-peg4-ch2ch2cooh is a polyethylene glycol (peg) derived linker, designed specifically for constructing proteolysis targeting chimeras (protacs)[1].
Pyrene-amido-PEG4-azide；化合物 T16691Pyrene-amido-PEG4-azide (2024/9/1)
简介：pyrene-amido-peg4-azide is a peg-based proteolysis targeting chimera (protac) linker utilized for synthesizing protacs [1].
Pyrazofurin；化合物 T16690Pyrazofurin (2024/9/1)
简介：pyrazofurin is a pyrimidine nucleoside analogue, inhibits cell proliferation and dna synthesis in cells by inhibiting ump synthase. pyrazofurin is a sensitive orotate-phosphoribosyltransferase inhibitor (ic50s between 0.06-0.37 μm in the cell lines hep-2, hnscc-14b, and hnscc-14c).
Pyranine溶剂绿7溶剂绿7|||HPTS|||Solvent Green 7 (2024/9/1)
简介：pyranine (solvent green 7) is reported as a new class of fluorescent chemosensor for the cu+ ion.
Pyr6；化合物Pyr6N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide；N- (2024/9/1)
简介：pyr6 (n-[4-[3,5-bis(trifluoromethyl)-1h-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide) is a selective trpc3 inhibitor with ic50 of 0.49 um(ca2+ influx inhibition in thapsigargin depleted native rbl-2h3 cells).pyr6 is an inhibitor of ca2+ entry, which displays higher potency to inhibit ca2+ entry mediated by crac channel than by trpc3.
Pyr3；化合物Pyr3Pyr3 (2024/9/1)
简介：pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. pyr3 inhibits trpc3-mediated ca2+ influx in a dose-dependent manner(ic50 = 700 nm).
Pyr10；化合物Pyr10Pyr10 (2024/9/1)
简介：pyr10 is a pyrazole derivative and a selective trp cation 3 inhibitor. pyr10 has the ability to distinguish between receptor-operated trpc3 and native stromal interaction molecule 1 (stim1)/orai1 channels. pyr10 inhibits ca2+ influx in carbachol-stimulated trpc3-transfected hek293 cells (ic50: 0.72 μm) (ic50 of 13.08 μm for store-operated ca2+ entry in brl-2h3 cells) .
Purpurogallin红倍酚红倍酚|||红陪酚 (2024/9/1)
简介：purpurogallin is a naturally phenol extracted from the plants of quercus spp. it has effective xanthine oxidase inhibitory activity (ic50: 0.2 μm). purpurogallin also has antioxidant and anti-inflammatory effects.
Puromycin aminonucleoside维生素E醋酸酯维生素E醋酸酯|||NSC 3056 (2024/9/1)
简介：puromycin aminonucleoside (nsc-3056) increases podocyte permeability by modulating zo-1 in an oxidative stress-dependent manner.
Pumosetrag Hydrochloride化合物 T16683MKC-733|||DDP-733 (2024/9/1)
简介：pumosetrag hydrochloride is an orally available 5-ht3 partial agonist. it is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.
Pumaprazole；普马拉唑BY-841；BY-841|||普马拉唑 (2024/9/1)
简介：pumaprazole (by-841) is an antagonist of a reversible proton pump.
Nesolicaftor；化合物PTI-428PTI-428；PTI-428 (2024/9/1)
简介：nesolicaftor (pti-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.
PTC-028；化合物PTC-028PTC-028 (2024/9/1)
简介：ptc-028 selectively suppresses cancer cells whereas normal cells remain unaffected. ptc-028 is an orally bioavailable inhibitor of stem cell factor bmi-1 in ovarian cancer. the depletion of bmi-1 by ptc-028 causes caspase-mediated apoptosis.
Vinblastine sulfate；硫酸长春碱NSC49842|||Vincaleukoblastine sulfate salt；硫酸长春碱|||NSC49842|||Vincaleukobla (2024/9/1)
简介：vinblastine sulfate (vincaleukoblastine sulfate salt) can inhibit the formation of microtubule, it also inhibits nachr(ic50=8.9 um).
Belzutifan；化合物BelzutifanPT2977|||MK-6482；PT2977|||MK-6482 (2024/9/1)
简介：belzutifan (mk-6482) is a potential treatment for clear cell renal cell carcinoma (ccrcc). belzutifan is an orally active and selective hif-2α inhibitor (ic50: 9 nm). belzutifan , as a second-generation hif-2α inhibitor, increases potency and improves pharmacokinetic profile.
PSN632408；化合物 T16678PSN632408 (2024/9/1)
简介：psn632408 is an optimized agonist of gpr119 receptors that display similar potency to oea at both recombinant mouse and human gpr119 receptors (ec50: 5.6 and 7.9 um, respectively).
Psicofuranine；化合物 T16677Psicofuranine (2024/9/1)
简介：psicofuranine also specifically inhibits gmp synthase and interrupts parasite growth. psicofuramine is a nucleoside antibiotic. it has the inhibition of xanthosine 5´-phosphate aminase. psicofuranine shows dose-dependent inhibition of p. falciparum growth(ic50: 0.3 mm).
MSN交谈
