9月
Pozanicline hydrochloride；化合物Pozanicline hydrochloridePozanicline hydrochloride (2024/9/1)
简介：pozanicline hydrochloride is an orally bioavailable nicotinic acetylcholine receptor (nachr) agonist with a ki of 16.7 nm for binding to [3h]cytisine sites[1]. pozanicline hydrochloride is an α4β2-selective nachr agonist, which binds to rat brain α4β2 nachr with a ki of 17 nm while binding to α7 nachr is insignificant[2].
Pozanicline；化合物 T16563ABT-089；ABT-089 (2024/9/1)
简介：pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction. pozanicline selectively activate neuronal nicotinic acetylcholine receptor (nachr) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2 nachrs (ki=16 nm). it shows high selectivity for α6β2 and α4α5β2 nachr subtypes, the binding affinity (ki, rat) for pozanicline to [3h] cytisine sites is 16.7 nm .
Ponceau 4R胭脂红Acid Red 18|||New Coccine (2024/9/1)
简介：ponceau 4r (acid red 18) is a synthetic strawberry red azo dye that is a food colorant dye used in a variety of food products. it is stable to light, heat and acid, but fades in the presence of ascorbic acid. it is usually synthesized from aromatic hydrocarbons.
Polyoxyethylene stearate；聚氧乙烯硬脂酸酯POES；POES|||聚氧乙烯硬脂酸酯 (2024/9/1)
简介：polyoxyethylene stearate (poes) is an agent of non-ionic emulsifying.
Poloxin；化合物PoloxinPoloxin (2024/9/1)
简介：poloxin is a non-atp competitive polo-like kinase 1 inhibitor. it targets the polo-box domain (ic50: appr 4.8 μm).
Vandetanib凡德他尼ZD6474|||凡德他尼 (2024/9/1)
简介：vandetanib (zd6474) is a potent inhibitor of vegfr2 (ic50: 40 nm). it also inhibits vegfr3 and egfr.
Poloxime；化合物 T16559Poloxime (2024/9/1)
简介：poloxime is a hydrolysis product of poloxin and is a non-atp-competitive plk1 inhibitor. it also has moderate plk1 inhibitory activity.
Polidocanol聚多卡醇Polyoxyethylene lauryl ether|||Polyoxyethyleneglycol Dodecyl Ether (2024/9/1)
简介：polidocanol (polyoxyethylene lauryl ether) is an alkyl polyethylene glycol ether of lauryl alcohol, which is a derivative of natural fatty or alkyl alcohols in natural mineral oil and is a hardener. polidocanol can be used as a local anesthetic, but in combination with other anesthetic drugs there is a risk of enhancing the effects of the anesthetic drugs on the cardiovascular system.
PNU-159682；化合物PNU-159682PNU-159682 (2024/9/1)
简介：pnu-159682 is a highly effective metabolite of the anthracycline nemorubicin. pnu-159682 has outstanding cytotoxicity. pnu-159682 is an effective adcs cytotoxin.
PNU-142633化合物 T16556PNU 142633|||PNU142633 (2024/9/1)
简介：pnu-142633 has anti-migraine efficacy. pnu-142633 is a high affinity and selective 5-ht1d receptor agonist (kis of 6 nm and > 18 000 nm for human 5-ht1d receptor and human 5-ht1b receptor, respectively).
PNU-103017；化合物 T16555PNU-103017 (2024/9/1)
简介：pnu-103017 is an inhibitor of hiv protease.
PNPP；4-硝基苯磷酸二钠PNPP (2024/9/1)
简介：pnpp is a non-proteinaceous chromogenic substrate for alkaline and acid phosphatases used in elisa and conventional spectrophotometric assays.
Pneumadin, rat；化合物 T16553PNM；PNM (2024/9/1)
简介：pneumadin, rat (pnm) exerts a marked antidiuretic effect in animals has a functional avp system. pneumadin, rat (pnm) is a decapeptide, which possesses a potent stimulating effect on arginine-vasopressin (avp) release.
Pleuromutilin；截短侧耳素Mutilin 14-glycolate|||Drosophilin B；Mutilin 14-glycolate|||Drosophilin B|||截短侧耳素 (2024/9/1)
简介：pleuromutilin (drosophilin b) is an inhibitor of bacterial protein synthesis by binding to the 50s ribosomal subunit of bacteria.
Pladienolide B；普拉地内酯BPladienolide B (2024/9/1)
简介：pladienolide b is a potent spliceosome inhibitor, a macrolide isolated from streptomyces obtusususus mer-12, which targets the sf3b1 subunit of the spliceosome.pladienolide b exerts its antitumor effects by inhibiting pre-mrna splicing and inducing necrosis.pladienolide b possesses antitumor activity and can be used to study leukemia and lymphoid tumors. pladienolide b has antitumor activity and can be used to study leukemia and lymphoid tumors.
PKR-IN-C16；化合物PKR-IN-C16PKR-IN-C16 (2024/9/1)
简介：pkr-in-c16 is a specific protein kinase (pkr) inhibitor. pkr-in-c16 is able to inhibit the autophosphorylation of pkr and unlock the translation blockade induced by pkr in primary neuronal cultures.pkr-in-c16 binds the atp-binding site of pkr and blocks autophosphorylation with an ic50 value of 186-210 nm. pkr-in-c16 protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress.
Ambrisentan；安倍生坦BSF-208075|||BSF 208075|||LU 208075；BSF-208075|||BSF 208075|||安倍生坦|||LU 208075 (2024/9/1)
简介：ambrisentan (bsf 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (pah). ambrisentan has been associated with a low rate of serum enzyme elevations during therapy but has yet to be implicated in cases of clinically apparent acute liver injury.
PKI-166；化合物PKI-166PKI-166 (2024/9/1)
简介：pki-166 is an oral inhibitor of egf-r tyrosine kinase (ic50:0.7 nm) that is both effective and selective. pki-166 can effectively inhibit the growth and metastasis of various human cancer cells including pancreatic cancer.
PKF050-638；化合物 T16548PKF050-638 (2024/9/1)
简介：pkf050-638 inhibits the crm1-mediated rev nuclear export by disrupting crm1-nes interaction. pkf050-638 is an effective and selective inhibitor of hiv-1 rev (ic50=0.04 μm).
PK14105；化合物 T16547PK14105 (2024/9/1)
简介：pk14105 has been evaluated biologically as a potential radioligand for positron emission tomography (pet) studies targeting peripheral benzodiazepine binding sites (pbbs) receptors. when administered to rats with unilaterally lesioned striata, pk14105 was observed to quickly cross the blood-brain barrier, displaying significant radioactivity retention in the lesioned striatum, in contrast to the unlesioned striatum or cerebellar vermis. additionally, pk14105 has the capability to inhibit recepto
PK 11195化合物 T16546RP 52028 (2024/9/1)
简介：pk 11195 is a ligand of translocator protein. it targets leishmania chemotherapy (ic50s of 14.2 μm, 8.2 μm, 3.5 μm for l. amazonensis, l. major and l. braziliensis, respectively).
Pivanex；化合物PivanexPivalyloxymethyl butyrate|||AN-9；Pivalyloxymethyl butyrate|||AN-9 (2024/9/1)
简介：pivanex (pivalyloxymethyl butyrate) is an orally active hdac inhibitor and an antimetastatic and antiangiogenic agent. pivanex downregulates the bcr-abl protein and enhances apoptosis.
Pivalopril；化合物 T16544Pivopril|||RHC 3659(S)；Pivopril|||RHC 3659(S) (2024/9/1)
简介：pivalopril is a new orally active inhibitor of angiotensin-converting enzyme.
Pironetin；化合物 T16543Pironetin (2024/9/1)
简介：pironetin binds to α-tubulin and is an effective inhibitor of microtubule polymerization. it also has cell cycle arrest and antitumor activity. pironetin is an α/β unsaturated lactone isolated from streptomyces species.
Piromidic acid吡咯酸吡咯酸|||吡乙酸三氮萘 (2024/9/1)
简介：piromidic acid is an antibacterial agent. piromidic acid is active against gramnegative bacteria and staphylococci. it is used for urinary tract and intestinal infections.
Pirolate；化合物 T16541CP-32387；CP-32387 (2024/9/1)
简介：pirolate is a receptor of histamine h1.
Piperazine Erastin；哌嗪ErastinPiperazine Erastin (2024/9/1)
简介：piperazine erastin is an analog of erastin. it causes an iron-dependent form of non-apoptotic cell death termed ferroptosis.
Pentamidine isethionate喷他脒羟乙磺酸盐Pentamidine isethionate salt|||Pentamidine diisethionate|||喷他脒羟乙磺酸盐 (2024/9/1)
简介：pentamidine isethionate (pentamidine diisethionate) is a synthetic amidine derivative, pentamidine isethionate is an antiprotozoal and antifungal agent.
Piperazine citrate；枸橼酸哌嗪Piperazine citrate (2024/9/1)
简介：piperazine citrate, an organic compound, consists of a six-membered ring, containing two nitrogen atoms at opposite positions in the ring. it used as an anthelmintic.
PIN1 inhibitor API-1；化合物PIN1 inhibitor API-1PIN1 inhibitor API-1 (2024/9/1)
简介：pin1 inhibitor api-1 is a specific pin1 inhibitor (ic50: 72.3 nm). pin1 inhibitor api-1 retains the active conformation of pxpo5 and restores the ability of pxpo5 to transport pre-mirnas from the nucleus to cytoplasm, thus up-regulating the anticancer mirna biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development. pin1 inhibitor api-1 directly and specifically binds to the pin1 peptidyl-prolyl isomerase domain and effectively inhibits pin1 cis-trans isomerizing activ
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