9月
Reproxalap；化合物ReproxalapNS-2|||ADX-102；NS-2|||ADX-102 (2024/9/1)
简介：reproxalap (ns-2) covalently binds aldehydes including malondialdehyde and 4-hydroxynonenal. reproxalap is a reactive aldehyde species sequestering agent for the treatment of the dry eye.
Rentiapril racemate；伦唑普利外消旋体(Rac)-SA-446|||SA-446 racemate|||(Rac)-Rentiapril；(Rac)-SA-446|||SA-446 (2024/9/1)
简介：rentiapril racemate (sa-446 racemate) is the racemate of rentiapril.rentiapril racemate has anti-inflammatory activity and may be used in glaucoma research.
Remibrutinib；化合物RemibrutinibRemibrutinib (2024/9/1)
简介：remibrutinib inhibits btk activity with an ic50 value of 0.023 μm in blood. remibrutinib is an effective and orally active bruton tyrosine kinase inhibitor (ic50: 1 nm). remibrutinib has the potential for chronic urticaria (cu) treatment.
Acamprosate calcium；阿坎酸钙calcium acetylhomotaurinate|||N-Acetylhomotaurine Calcium|||Alcomed|||Sobrio (2024/9/1)
简介：acamprosate calcium (campral ec) is a gaba receptor agonist and modulator of glutamatergic systems, used for treating alcohol dependence.
Remetinostat；化合物RemetinostatSHP-141；SHP-141 (2024/9/1)
简介：remetinostat (shp-141), a hydroxamic acid-based inhibitor of histone deacetylase enzymes, is currently being developed for the treatment of cutaneous t-cell lymphoma.
Relacorilant；化合物RelacorilantCORT 125134；CORT 125134 (2024/9/1)
简介：relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(ki of 7.2 nm in hepg2 tat assay, and also shows kis of 12, 81.2, 210 nm for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively). relacorilant has the potential for cushing’s syndrome treatment.
Rebeccamycin；化合物 T16726Rebeccamycin (2024/9/1)
简介：rebeccamycin is an antitumor antibiotic+ inhibits dna topoisomerase i. rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase i. it also has a negligible effect on protein kinase c and topoisomerase ii.
RCM-1；化合物RCM-1RCM-1 (2024/9/1)
简介：rcm-1 is an inhibitor of foxm1.
Razuprotafib；化合物RazuprotafibAKB-9778；AKB-9778 (2024/9/1)
简介：razuprotafib (akb-9778) is a protein tyrosine phosphatase ß (hptpß) inhibitor (ic50: 50 nm). razuprotafib is effective for the activation of tie-2 and is protective against acute kidney injury.
Ranirestat；化合物 T16723AS-3201；AS-3201 (2024/9/1)
简介：ranirestat effective and orally active aldose reductase inhibitor ( ic50s: 11 nm and 15 nm for rat lens ar and recombinant human ar, respectively and a ki: 0.38 nm for recombinant human ar). ranirestat has a neuroprotective effect on diabetic retinas.
Ralimetinib；化合物 T16721LY2228820；LY2228820 (2024/9/1)
简介：ralimetinib selectively inhibits phosphorylation of mk2 (thr334) and has no effect on phosphorylation of p38α mapk, jnk, erk1/2, c-jun, atf2, or c-myc. ralimetinib is an effective and selective, atp-competitive inhibitor of p38 mapk α/β (ic50s: 5.3 and 3.2 nm, respectively).
Rafigrelide；化合物 T167203,3-Dimethylanagrelide；3,3-Dimethylanagrelide (2024/9/1)
简介：rafigrelide is a platelet-lowering agent.
Dimesna；地美司钠BNP-7787；地美司钠|||BNP-7787 (2024/9/1)
简介：dimesna (bnp-7787) is a synthetic derivative of dithio-ethane sulfonate with uroprotective properties.
Radicicol；根赤壳菌素Monorden；根赤壳菌素|||Monorden (2024/9/1)
简介：radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting p. falciparum topoisomerase vib. radicicol is an inhibitor of hsp90 (ic50: 1 μm). radicicol binds to the atpase domain of hsp90 and prevents maturation of hsp90 clients, leading to proteasomal degradation.
Radezolid；雷得唑来RX-1741；RX-1741|||雷得唑来 (2024/9/1)
简介：radezolid (rx-1741) is a novel oxazolidinone antibiotic agent.
Radequinil；化合物 T16717AC-3933；AC-3933 (2024/9/1)
简介：radequinil is a benzodiazepine receptor partial inverse agonist. rade quinil binds to gaba(-) and gaba(+) ligand (kis: 5.15 and 6.11 nm, respectively).
Rabacfosadine；雷巴萨定VDC-1101|||GS-9219；VDC-1101|||GS-9219 (2024/9/1)
简介：rabacfosadine (gs-9219) is a novel dual pre-drug of the acyclic nucleotide phosphonate pmeg to tumor lymphocytes for the study of lymphoma.
Furaprofen；呋喃洛芬R803；呋喃洛芬|||R803 (2024/9/1)
简介：furaprofen is substantially more potent against genotype 1a and 1b replicons (ec50, ~30 nm) than against the genotype 2a replicon (ec50:1000 nm). furaprofen is an effective hcv replication inhibitor.
Saperconazole；沙康唑R66905；沙康唑|||R66905 (2024/9/1)
简介：saperconazole is a broad-spectrum antifungal triazole (mic90: 0.19 mg/l).
R121919；化合物R121919NBI30775；NBI30775 (2024/9/1)
简介：r121919 (nbi30775) is a potent small molecule adrenocorticotropic hormone-releasing factor receptor 1 (crf1) receptor antagonist with antidepressant and anxiolytic activity that inhibits the crf1 receptor, the crf2 receptor, and the crf-binding proteins.
(R)-Pantetheine；化合物 T16712Pantetheine；Pantetheine (2024/9/1)
简介：(r)-pantetheine is the biosynthetic precursor to coa. (r)-pantetheine and its corresponding disulfide pantethine play a key role in metabolism .
Flesinoxan；化合物 T16711Flesinoxan (2024/9/1)
简介：flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1a receptor agonist (ec50: 24 nm).
Mericitabine；化合物MericitabineR-7128|||RG 7128|||PSI 6130 diisobutyrate；R-7128|||RG 7128|||PSI 6130 di (2024/9/1)
简介：mericitabine (r-7128) is a nucleoside hcv ns5b polymerase inhibitor. it acts as an rna chain terminator and prevents the elongation of rna transcripts during replication.
Mirabegron；米拉贝隆YM178；YM178|||米拉贝隆 (2024/9/1)
简介：mirabegron (ym178) is a beta-3 adrenergic agonist that is used for treatment of overactive bladder syndrome.
R 59-022；化合物 T16709Diacylglycerol kinase inhibitor I|||DKGI-I；Diacylglycerol kinase inhibitor I|||DK (2024/9/1)
简介：r 59-022 is a 5-htr antagonist and activates protein kinase c (pkc). r 59-022 is a diacylglycerol kinase inhibitor (ic50=2.8 μm). r 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.
R-268712；化合物R-268712R-268712 (2024/9/1)
简介：r-268712 is a specific activin receptor-like kinase 5 (alk5) inhibitor(ic50 of 2.5 nm). it is also an orally active transforming growth factor-β type i receptor inhibitor.
Quinoclamine灭藻醌灭藻醌|||2-氨基-3-氯-1,4-萘醌 (2024/9/1)
简介：quinoclamine is a naphthoquinone derivative and is an nf-κb inhibitor.
Quinfamide；喹法米特WIN-40014；喹法米特|||WIN-40014 (2024/9/1)
简介：quinfamide is a compound with the potential to treat tropical parasitic infections such as amoebiasis and helminthiasis.
Quilseconazole Formic acid(1340593-70-5 Free base)；化合物 Quilseconazole Formic acid(1340593-70-5 Free (2024/9/1)
简介：quilseconazole formic acid is a selective inhibitor of fungal cyp51 with potent activities against cryptococcus neoformans and cryptococcus gattii.
Quilseconazole；化合物 T16704VT-1129；VT-1129 (2024/9/1)
简介：quilseconazole is an effective, orally active fungal cyp51 inhibitor. it also binds tightly to cryptococcal cyp51 but weakly inhibits humans cyp450 enzymes.
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