9月
Propargyl-PEG1-SS-PEG1-C2-Boc；化合物 T16590Propargyl-PEG1-SS-PEG1-C2-Boc (2024/9/1)
简介：propargyl-peg1-ss-peg1-c2-boc is a cleavable adc linker used in the synthesis of antibody-drug conjugates (adcs)[1].
Melatonin；褪黑素Melatonine|||N-Acetyl-5-methoxytryptamine；Melatonine|||松果体素|||N-Acetyl-5-methoxytryptam (2024/9/1)
简介：melatonin (melatonine) is a biogenic amine that is found in animals and plants. in mammals, melatonin is produced by the pineal gland. its secretion increases in darkness and decreases during exposure to light. melatonin is implicated in the regulation of sleep, mood, and reproduction. melatonin is also an effective antioxidant.
Propargyl-PEG1-SS-PEG1-acid；化合物 T16589Propargyl-PEG1-SS-PEG1-acid (2024/9/1)
简介：propargyl-peg1-ss-peg1-acid is a two-unit polyethylene glycol (peg) linker that is cleavable and commonly employed in the synthesis of antibody-drug conjugates (adcs) [1].
Propargyl-PEG1-SS-alcohol；化合物 T16588Propargyl-PEG1-SS-alcohol (2024/9/1)
简介：propargyl-peg1-ss-alcohol is a 1-unit peg adc linker that is cleavable. it finds application in the synthesis of antibody-drug conjugates (adcs)[1].
Propargyl-PEG1-NHS ester；化合物 T16587Propargyl-PEG1-NHS ester (2024/9/1)
简介：propargyl-peg1-nhs ester is a non-cleavable 1-unit peg linker employed in antibody-drug conjugation (adc) to connect antibodies with drugs.
Propargyl-PEG1-NH2；化合物 T16586Propargyl-PEG1-NH2 (2024/9/1)
简介：propargyl-peg1-nh2 is a peg-based protac linker can be used in the synthesis of protacs[1].
Propargyl-PEG1-acrylate；化合物 T16584Propargyl-PEG1-acrylate (2024/9/1)
简介：propargyl-peg1-acrylate is a polyethylene glycol (peg) derived linker employed in the synthesis of proteolysis-targeting chimeras (protacs)[1].
Propargyl-PEG1-acid；化合物 T16583Propargyl-PEG1-acid (2024/9/1)
简介：propargyl-peg1-acid, a peg-based protac linker, enables the synthesis of btk-crbn protacs, specifically ibrutinib-based protac 4 and protac 5. at a concentration of 10 μm, protac 5 facilitates the degradation of btk and induces the degradation of csk, lyn, and lat2[1].
Propanil；敌稗Propanil (2024/9/1)
简介：propanil is a widely used contact herbicide. it is mainly used in rice production.
Progabide；化合物ProgabideSL 76002|||Halogabide|||Gabren|||Gabrene；SL 76002|||Halogabide|||Gabren|||Gabr (2024/9/1)
简介：progabide (sl 76002) is an agonist of the gamma-aminobutyric acid receptor.
Prodigiosin；灵菌红素Prodigiosine；Prodigiosine|||灵菌红素 (2024/9/1)
简介：prodigiosin is a secondary metabolite of symbiotic bacteria. it also has anti-fungal and anti-cancer activity.
Selenomethionine硒代蛋氨酸DL-Selenomethionine|||DL-硒代蛋氨酸|||Seleno-DL-methionine|||硒代蛋氨酸 (2024/9/1)
简介：dl-selenomethionine (seleno-dl-methionine) is a selenium (se) analogue of methionine in which sulfur is replaced with the trace element selenium. selenomethionine (semet) can incorporate into proteins in place of methionine with no effects on protein structure and function, providing a mechanism for reversible se storage in organs and tissues.
Pro-xylane；玻色因Hydroxypropyl tetrahydropyrantriol；玻色因|||Hydroxypropyl tetrahydropyrantriol (2024/9/1)
简介：pro-xylane is a biochemical which induces neo-synthesis of matrix proteins. it is a biologically active c-glycoside in aqueous media, acts as an activator of glycosaminoglycans (gags) biosynthesis. pro-xylane (hydroxypropyl tetrahydropyrantriol) is the first example of ´green´ chemical used in cosmetic.
PRN694；化合物 T16578PRN694 (2024/9/1)
简介：prn694 shows extended target residence time on itk and rlk, enabling durable attenuation of effector cells in vitro and in vivo. prn694 is an irreversible, highly selective, and effective covalent interleukin-2-inducible t-cell kinase (itk) and resting lymphocyte kinase (rlk) dual inhibitor (ic50s: 0.3 nm and 1.4 nm, respectively).
PRMT5-IN-2；化合物 T16577PRMT5-IN-2 (2024/9/1)
简介：prmt5-in-2 is an inhibitor of protein arginine methyltransferase 5.
Pritelivir mesylate化合物 T16576BAY 57-1293 mesylate|||AIC316 mesylate (2024/9/1)
简介：pritelivir mesylate is active against herpes simplex virus types 1 and 2 (ic50: 0.02 μm against hsv1-2). pritelivir mesylate is an inhibitor of the viral helicase-primase complex. pritelivir mesylate shows antiviral activity in vitro and in animal models of herpes simplex virus (hsv) infection.
Pritelivir mesylate hydrate化合物 T16575BAY 57-1293 mesylate hydrate|||AIC316 mesylate hydrate (2024/9/1)
简介：pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (ic50: 0.02 μm against hsv1-2). pritelivir mesylate hydrate is an inhibitor of the viral helicase-primase complex. pritelivir mesylate hydrate shows antiviral activity in vitro and in animal models of herpes simplex virus (hsv) infection.
Pregnenolone monosulfate sodium salt；化合物 T165743β-Hydroxy-5-pregnen-20-one monosulfate sodium salt；3 (2024/9/1)
简介：pregnenolone monosulfate sodium salt is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication. pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of the cannabinoid cb1 receptor. pregnenolone monosulfate sodium salt also inhibits the effects of tetrahydrocannabinol (thc) that are mediated by the cb1 receptors.
Pratosartan；化合物 T16573KT 3671|||FW 7203|||KD 3-671；KT 3671|||FW 7203|||KD 3-671 (2024/9/1)
简介：pratosartan is a selective antagonist of angiotensin ii receptor.
Prasugrel (Maleic acid)；马来酸普拉格雷PCR 4099 (Maleic acid)；马来酸普拉格雷|||PCR 4099 (Maleic acid) (2024/9/1)
简介：prasugrel maleic acid is an orally active and potent p2y12 receptor antagonist and inhibits adp-induced platelet aggregation. prasugrel maleic acid is a thienopyridine and prodrug. prasugrel maleic acid also inhibits platelet function.
Pranidipine；普拉地平OPC-13340；普拉地平|||OPC-13340 (2024/9/1)
简介：pranidipine (opc-13340) is a novel, long-acting 1,4-dihydropyridine calcium channel blocker. it prolongs acetylcholine-induced relaxation in presence of endothelium as well as nitroglycerin-induced relaxation in absence of endothelium. it also has antihypertensive activity.
Pralnacasan；化合物 T16570VX-740|||HMR 3480；VX-740|||HMR 3480 (2024/9/1)
简介：pralnacasan inhibits proinflammatory cytokines il-18, il-1β , and ifn-γ. pralnacasan is an effective, non-peptide, and orally active interleukin-1β converting enzyme inhibitor (ki: 1.4 nm). pralnacasan has the potential for osteoarthritis and rheumatoid arthritis treatment.
Varenicline Tartrate；酒石酸伐尼克兰Champix tartrate|||Chantix tartrate|||CP 526555-18；Champix tartrate|||酒石 (2024/9/1)
简介：varenicline tartrate (cp 526555-18) is a benzazepine derivative that functions as an alpha4/beta2 nicotinic receptor partial agonist. it is used for smoking cessation.
Vandetanib Fumarate；化合物 T1656LHSDB 8198|||Zactima|||Caprelsa|||ZD 6474|||Vandetanib；HSDB 8198|||Zact (2024/9/1)
简介：vandetanib fumarate is an orally available tyrosine kinase inhibitor. vandetanib fumarate works by blocking ret (rearranged during transfection), vascular endothelial growth factor receptor (vegfr-2, vegfr-3), and epidermal growth factor receptor and to a lesser extent vegfr-1, which are important targets in thyroid cancer (tc).
Praliciguat；化合物PraliciguatIW-1973；IW-1973 (2024/9/1)
简介：praliciguat (iw-1973) stimulates sgc in hek-293 cells (ec50: 197 nm). praliciguat is an effective and orally active soluble guanylate cyclase stimulator. it also enhances no signaling and acts as a vasodilator.
PR-924；化合物 T16568PR-924 (2024/9/1)
简介：pr-924 is a selective inhibitor of tripeptide epoxyketone immunoproteasome subunit lmp-7 (ic50: 22 nm). pr-924 inhibits growth and triggers apoptosis in multiple myeloma (mm) cells. pr-924 has antitumor activities. pr-924 covalently modifies proteasomal n-terminal threonine active sites.
PQR530；化合物PQR-530PQR-530；PQR-530 (2024/9/1)
简介：pqr530 is a highly potent dual pan-pi3k/mtorc1/2 inhibitor. pqr530 inhibited protein kinase b (pkb, pser473) and ribosomal protein s6 (ps6, pser235/236) phosphorylation with ic50 values of 0.07 μm. it also showing antitumor activity.
Propyl pyrazole triol；化合物Propyl pyrazole triolPPT；PPT (2024/9/1)
简介：propyl pyrazole triol (ppt) is a selective agonist of estrogen receptor alpha. the relative binding affinity of propyl pyrazole triol for erα (erα: 49%) around 410 times higher compared with estrogen receptor beta (erβ: 0.12%).
Ppc-1；化合物 T16565Ppc-1 (2024/9/1)
简介：ppc-1 is a chemical compound known for its inhibitory effects on the gram-negative periodontopathogen porphyromonas gingivalis. it acts as a mitochondrial uncoupler, enhancing mitochondrial oxygen consumption without affecting atp production. additionally, ppc-1 serves as a cell-permeate inhibitor of interleukin-2 (il-2). this compound exhibits various beneficial activities, including anti-obesity, antibacterial, and anti-inflammatory properties.
PPADS tetrasodium；化合物PPADS四钠盐PPADS tetrasodium (2024/9/1)
简介：ppads tetrasodiuma is a potent p2x receptor antagonist and inhibitor of the inverse mode of na/ca²⁺ exchange in guinea pig airway smooth muscle and is neuroprotective against glutamate/nmda toxicity.ppads tetrasodiuma inhibits p2x1, p2x-2, p2x-3, and p2x- 5. 5.
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