9月
SEC inhibitor KL-1；化合物SEC inhibitor KL-1KL-1；KL-1 (2024/9/1)
简介：sec inhibitor kl-1 (kl-1) exhibits a dose-dependent inhibitory effect on aff4-ccnt1 interaction (ki: 3.48 μm). sec inhibitor kl-1 is a potent, selective super elongation complex (sec) inhibitor and disrupts the interaction between the sec scaffolding protein aff4.
SDZ281-977；化合物 T16866SDZ-LAP 977；SDZ-LAP 977 (2024/9/1)
简介：sdz 281-977 is a derivative of lavendustin a which is the egf receptor tyrosine kinase inhibitor.
SCH28080；化合物SCH28080SCH28080 (2024/9/1)
简介：sch28080 is a reversible and k+-competitive inhibitor of gastric h+/k+-atpase with an ic50 value of 20 nm (rabbit microsomal membrane).sch28080 is a potent inhibitor of acid secretion in vivo with anti-ulcer activity, anti-secretory and cytoprotective activity.
SCH 563705；化合物 T16864SCH 563705 (2024/9/1)
简介：sch 563705 is an effective and orally available cxcr2 and cxcr1 antagonist (ic50s: 1.3 nm, 7.3 nm and kis of 1 and 3 nm, respectively).
SCH 546738；化合物 T16863SCH 546738 (2024/9/1)
简介：sch 546738 is an effective and non-competitive cxcr3 antagonist. sch 546738 bindings to the human cxcr3 receptor is determined (ki: 0.4 nm) in multiple experiments.
SCH-1473759；化合物 T16862SCH-1473759 (2024/9/1)
简介：sch-1473759 is an inhibitor of the aurora (ic50s: 4 and 13 nm for aurora a and b, respectively).
SB 204990；化合物SB 204990SB 204990 (2024/9/1)
简介：sb 204990 is an effective and specific atp citrate lyase enzyme inhibitor.
SBI-553；化合物SBI-553SBI-553 (2024/9/1)
简介：sbi-553 is an effective and brain penetrant ntr1 allosteric modulator (ec50: 0.34 μm).
Hematoxylin；苏木精Hydroxybrazilin|||Natural Black 1|||Haematoxylin；苏木精|||Hydroxybrazilin|||Natural Blac (2024/9/1)
简介：hematoxylin (natural black 1) is a dye obtained from the heartwood of logwood (haematoxylon campechianum linn., leguminosae) used as a stain in microscopy and in the manufacture of ink.
SBI-425；化合物SBI-425SBI-425 (2024/9/1)
简介：sbi-425 is an effective and orally bioavailable inhibitor of tissue-nonspecific alkaline phosphatase (tnap). sbi-425 effectively inhibits tnap in the vasculature and improves cardiovascular parameters and survival without a detectable change in the bone.
SBE-β-CD磺丁基-Β-环糊精磺丁基-Β-环糊精|||Sulfobutylether-β-Cyclodextrin (2024/9/1)
简介：sbe-β-cd (sulfobutylether-β-cyclodextrin) is a β-cyclodextrin derivative with a sodium sulfonate salt separated from the lipophilic cavity by a butyl ether spacer group, or sulfobutylether. sbe-β-cd is widely used as a co-solvent in biological experiments.
SB269652；化合物 T16857SB269652 (2024/9/1)
简介：sb269652 is the first drug-like allosteric modulator of the dopamine d2 receptor.
SB228357；化合物SB228357SB228357 (2024/9/1)
简介：sb228357 is a potent and selective antagonist of the 5-ht receptor with pkis of 6.9, 8.0, and 9.0 for 5-ht2a, 5-ht2b, and 5-ht2c, respectively.
SB-772077B dihydrochloride；化合物 T16855SB-772077B dihydrochloride (2024/9/1)
简介：sb-772077b dihydrochloride is an aminofurazan-based rho kinase inhibitor (ic50s: 5.6 nm and 6 nm toward rock1 and rock2, respectively).
SB-674042；化合物 SB-674042SB674042；SB674042 (2024/9/1)
简介：sb-674042 is a potent and selective dual antagonist of the non-peptide orexigenic peptides ox1 and ox2 receptors, with ic50s of 3.76 nm and 531 nm, respectively.sb-674042 can be used for the treatment of depression.
SB-633825；化合物 T16853SB-633825 (2024/9/1)
简介：sb-633825 can inhibit cancer cell growth and angiogenesis. sb-633825 is an effective and atp-competitive inhibitor of tie2, lok, and brk (ic50s: 3.5 nm, 66 nm, 150 nm, respectively).
SB-568849；化合物 T16852SB-568849 (2024/9/1)
简介：sb-568849 is a melanin-concentrating hormone receptor 1 antagonist (pki: 7.7).
SB-267268；化合物 T16851SB-267268 (2024/9/1)
简介：sb-267268 inhibits human and mouse αvβ3 (ic50s: 0.68 and 0.29 nm, respectively). sb-267268 is a selective and nonpeptidic alpha(v)beta3 and alpha(v)beta5 integrins antagonist (kis: 0.9, 0.5 and 0.7 nm for human αvβ3, monkey αvβ3 and human αvβ5, respectively).
SB-265610；化合物SB-265610GSK-CXCR2；GSK-CXCR2 (2024/9/1)
简介：sb-265610 (gsk-cxcr2) is a nonpeptide and allosteric cxcr2 antagonist. sb-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (cinc-1)-induced calcium mobilization and neutrophil chemotaxis (ic50s: 3.7 nm and 70 nm, respectively).
2-Amino-5-chlorobenzophenone；氨基酮2-Amino-5-chlorobenzophenone (2024/9/1)
简介：2-amino-5-chlorobenzophenone is used as pharmaceutical intermediates.
SB-222200；化合物SB-222200SB-222200 (2024/9/1)
简介：sb-222200 is a selective, reversible, and competitive antagonist of the human nk-3 receptor(ki=4.4 nm).
SB-218078；化合物 T16848SB-218078 (2024/9/1)
简介：sb-218078 is less potently inhibits cdc2 (ic50: 250 nm) and pkc (ic50: 1000 nm). sb-218078 is a potent, atp-competitive, and cell-permeable checkpoint kinase 1 inhibitor that inhibits chk1 phosphorylation of cdc25c (ic50: 15 nm).
SA 47；化合物 T16847SA 47 (2024/9/1)
简介：sa 47 is a selective and effective inhibitor of fatty acid amide hydrolase and carbamate.
Sauristolactam；化合物 T16846Saurolactam；Saurolactam (2024/9/1)
简介：sauristolactam inhibits the receptor activator of nuclear factor-κb ligand (rankl)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation. sauristolactam, a natural aristolactam isolated from aerial portions of saururus chinensis. sauristolactam has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells.
Sarolaner；化合物SarolanerPF-6450567；PF-6450567 (2024/9/1)
简介：sarolaner (pf-6450567) is an orally active and broad-spectrum ectoparasiticide (lc80: 0.3 μg/ml against c. felis and an lc100: 0.003 μg/ml against o. turicata).
Sarmazenil；沙马西尼R-154513|||Ro 15-3505；R-154513|||Ro 15-3505 (2024/9/1)
简介：sarmazenil (ro 15-3505) is a partial inverse agonist at the benzodiazepine receptor with pro-convulsant properties and is used in the study of chronic hepatic encephalopathy (he).
Saridegib化合物 T16843IPI-926|||Patidegib (2024/9/1)
简介：saridegib is an effective and specific inhibitor of smoothened and a key signaling transmembrane protein in the hedgehog pathway.
Saredutant；化合物 T16842SR 48968C|||SR 48968；SR 48968C|||SR 48968 (2024/9/1)
简介：saredutant is an antagonist of selective nk2 receptors.
SAR-260301；化合物 T16841SAR-260301 (2024/9/1)
简介：sar-260301 is an orally available and selective inhibitor of pi3kβ (ic50: 23 nm).
Sampatrilat；化合物 T16840UK-81252；UK-81252 (2024/9/1)
简介：sampatrilat is an effecive and orally active vasopeptidase inhibitor of ace and neutral endopeptidase. sampatrilat inhibits c-domain ace (ki=13.8 nm) 12.4-fold more potent than that for the n-domain (ki=171.9 nm).
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