9月
Pimonidazole；哌莫硝唑Pimonidazole (2024/9/1)
简介：pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group. it can be used for qualitative and quantitative assessment of tumor hypoxia. pimonidazole is a novel hypoxia marker for the complementary study of tumor hypoxia and cell proliferation in tumors.
Pimonidazole hydrochloride；化合物Pimonidazole hydrochloridePimonidazole hydrochloride (2024/9/1)
简介：pimonidazole hydrochloride accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group. it can be used for qualitative and quantitative assessment of tumor hypoxia. pimonidazole hydrochloride is a novel hypoxia marker for the complementary study of tumor hypoxia and cell proliferation in tumors.
Picrotoxinin；木防己苦毒宁Picrotoxinin (2024/9/1)
简介：picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of gabaa with an ic50 of 1.15 μm for α1β2γ2l gabaa. picrotoxinin shows convulsant properties.
Picrotin；苦亭Picrotin (2024/9/1)
简介：picrotin is an inhibitor of glycine receptors. picrotin blocks α2 glyr, α1 glyr, and α3 glyr and can be used in studies about neurotransmission.
Pico145；化合物Pico145HC-608；HC-608 (2024/9/1)
简介：pico145 (hc-608) is a remarkable inhibitor of trpc1/4/5 channels. pico145 inhibits ( )-englerin a-activated trpc4/trpc5 channels (ic50s: 0.349 and 1.3 nm in cells) it also shows no effect on trpc3, trpc6, trpv1, trpv4, trpa1, trpm2, trpm8.
Picaridin；埃卡瑞丁Lcaridin；埃卡瑞丁|||Lcaridin (2024/9/1)
简介：picaridin (lcaridin) is a topical insect repellent.
BF738735；化合物BF738735BF738735 (2024/9/1)
简介：bf738735 is a selective inhibitor of phosphatidylinositol 4-kinase iii beta (pi4kiiiβ, ic50 = 5.7 nm) showing higher activity over α(ic50 = 1.7 μm). bf738735 exhibits a broad spectrum of antiviral activity.
BEBT-908；化合物BEBT-908PI3Kα inhibitor 1|||MDK9521；PI3Kα inhibitor 1|||MDK9521 (2024/9/1)
简介：bebt-908 (pi3kα inhibitor 1) is a selective pi3kα inhibitor (ic50 <0.1 μm). bebt-908 also inhibits hdac (0.1 μm≤ic50≤1 μm).
PI-828；化合物PI-828LY 294002, 4gamma-NH2；LY 294002, 4gamma-NH2 (2024/9/1)
简介：pi-828 is a phosphatidylinositol 3-kinase (pi3k) inhibitor, which is widely used to study the physiological function of pi3k and also promotes stem cell differentiation into mesoderm.
Phytic acid dodecasodium salt hydrate；植酸十二钠盐myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium (2024/9/1)
简介：phytic acid dodecasodium salt hydrate (myo-inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate) is a phosphorus storage compound of seeds and cereal grains. phytic acid dodecasodium salt hydrate inhibits the enzymatic superoxide source xanthine oxidase with an ic50 of 6 mm and has antioxidative, neuroprotective, and anti-inflammatory effects.
Phorbol 12,13-dibutyrate；化合物 T16526PDBu|||Phorbol dibutyrate；PDBu|||Phorbol dibutyrate (2024/9/1)
简介：phorbol 12,13-dibutyrate is a pkc activator. it also is a potent skin tumor promoter.
PhIP；化合物PhIPPhIP (2024/9/1)
简介：phip is a heterocyclic aromatic amine (haa) from cooked meat. it belongs to pyridine heterocyclic amine and is a 2b carcinogen with estrogen activity. phip forms adducts with dna that promote cancer.
Philanthotoxin 74 dihydrochloride；化合物Philanthotoxin 74 盐酸盐PhTx-74 HCl|||PhTx 74 dihydrochloride；PhTx (2024/9/1)
简介：philanthotoxin 74 dihydrochloride is an antagonist of ampar with ic50s of 263 and 296 nm for glur3 and glur1.
PhiKan 083；化合物PhiKan 083PhiKan 083 (2024/9/1)
简介：phikan 083 is a carbazole derivative
PhiKan 083 hydrochloride化合物 T16523PhiKan 083 hydrochloride (2024/9/1)
简介：phikan 083 hydrochloride is a carbazole derivative. which binds to the surface cavity and stabilizes y220c (kd: 167 μm). it also a relative binding affinity (kd) of 150 μm in ln229 cells.
Phenoxodiol脱氢雌马酚脱氢雌马酚|||Dehydroequol|||Idronoxil|||Haginin E (2024/9/1)
简介：phenoxodiol (idronoxil) activates the mitochondrial caspase system, inhibits x-linked inhibitor of apoptosis(xiap), disrupts flice inhibitory protein(flip) expression, and sensitizes the cancer cells to fas-mediated apoptosis. phenoxodiol induces cell cycle arrest in the g1/s phase of the cell cycle and upregulates p21waf1 via a p53 independent manner. phenoxodiol also inhibits dna topoisomerase ii.
Phenglutarimid；化合物 T16521Phenglutarimide|||Ciba 10870；Phenglutarimide|||Ciba 10870 (2024/9/1)
简介：phenglutarimid is an anticholinergic. it is used as an antiparkinsonian agent.
Ph-Bis(C1-N-(C2-NH-Boc)2)；化合物 T16520Ph-Bis(C1-N-(C2-NH-Boc)2) (2024/9/1)
简介：ph-bis(c1-n-(c2-nh-boc)2) is a versatile alkyl chain-derived linker employed in the synthesis of protacs[1].
BIM-46187 4HCl；化合物BIM-46187 4HClPH-064 4HCl；PH-064 4HCl (2024/9/1)
简介：bim-46187 4hcl (ph-064 4hcl) is a heterotrimeric g-protein complex inhibitor.
PH-064；化合物PH-064BIM-46187；BIM-46187 (2024/9/1)
简介：ph-064 (bim-46187) is a heterotrimeric g-protein complex inhibitor.
PH-002；化合物PH-002PH-002 (2024/9/1)
简介：ph-002, an inhibitor targeting the intramolecular domain interaction of apolipoprotein (apo) e4 in neuronal cells, additionally enhances mitochondrial motility and promotes neurite outgrowth, thereby countering related impairments.
PGMI-004A；化合物PGMI-004APGMI-004A (2024/9/1)
简介：pgmi-004a is an effective inhibitor of phosphoglycerate mutase 1 (ic50: 13.1 μm).
PG01；化合物PG01Phenylglycine-01；Phenylglycine-01 (2024/9/1)
简介：pg01 is a potent cftr cl-channel potentiator, effective against δf508 (ka 0.3 μm), and also against e193k, g970r and g551d (cftr mutants), with kd values of 0.22 μm, 0.45 μm and 1.94 μm, respectively.pg01 increases δf508-cftr cl- currents upon addition of forskolin. f508-cftr cl-current upon addition of forskolin, correcting the gating defect of cftr mutants.
PF 750；化合物PF 750PF-750|||UNII-7756CPP14K|||ZINC27647189；PF-750|||UNII-7756CPP14K|||ZINC27647189 (2024/9/1)
简介：pf 750 (zinc27647189) is a selective and covalent inhibitor of faah. pf 750 shows ic50s varying from 16.2 to 595 nm in different incubation times.
PF 04531083；化合物PF 04531083PF 04531083 (2024/9/1)
简介：pf 04531083 is a selective blocker of the nav1.8 channel. pf 04531083 can be used for neuropathic and inflammatory pain studies.
PF 03709270；化合物 T16513ulopenem etzadroxil；ulopenem etzadroxil (2024/9/1)
简介：pf 03709270 is an orally available ester prodrug form of sulopenem. it has broad-spectrum antibacterial activity against most gram-positive and gram-negative bacteria.
PFE-360；化合物PFE-360PF-06685360；PF-06685360 (2024/9/1)
简介：pfe-360 (pf-06685360) is a potent and selective inhibitor of lrrk2 kinase (ic50: 2.3 nm in vivo).
PF2562；化合物 T16511PF2562 (2024/9/1)
简介：pf2562 is a dopamine d1 ligand. it is used as a dopamine d1 agonist or partial agonist. pf2562 binds to human d1 receptor (ki: 113 nm). pf2562 shows activity against human d1 camp (ec50: 568 nm in htrf assay).
PF-915275；化合物PF-915275PF-915275 (2024/9/1)
简介：pf-915275 is an effective and selective inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11βhsd1, ki = 2.3 nm, ec50 = 15 nm in vitro hek293 cells). the dose-dependent effect of pf-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an ec50 of 20 and 100 nm, respectively.
Rabeprazole sodium；雷贝拉唑钠Dexrabeprazole Sodium|||LY307640 sodium|||Habeprazole Sodium|||Rebeprazole s (2024/9/1)
简介：rabeprazole sodium (habeprazole sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and zollinger-ellison syndrome. the drug inhibits h(+)-k(+)-exchanging atpase which is found in gastric parietal cells.
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