9月
PF-5190457；化合物PF-5190457PF-05190457；PF-05190457 (2024/9/1)
简介：pf-5190457 is an effective and selective ghrelin receptor inverse agonist (pki: 8.36).
PF-5006739；化合物 T16507PF-5006739 (2024/9/1)
简介：pf-5006739 is an effective and selective inhibitor of ck1δ/ε (ic50s: 3.9 nm and 17.0 nm, respectively). pf-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for ck1δ/ε and high kinome selectivity. pf-5006739 improves glucose tolerance in both diet-induced obesity (dio) and genetic (ob/ob) mice models of obesity. pf-5006739 decreases opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent m
PF-4878691；化合物PF-48786913M-852A；3M-852A (2024/9/1)
简介：pf-4878691 (3m-852a) is an effective and selective toll-like receptor 7 agonists modelled. it is used to dissociate its antiviral and inflammatory activities.
PF-4778574；化合物 T16505PF-4778574 (2024/9/1)
简介：pf-4778574 is a positive ampa receptor allosteric modulation (ec50: 45 to 919 nm in different cells).
PF-4693627；化合物 T16504PF-4693627 (2024/9/1)
简介：pf-4693627 is an effective and selective microsomal prostaglandin e synthase-1 inhibitor (ic50=3 nm). it is used for the treatment of inflammation caused by osteoarthritis (oa) and rheumatoid arthritis (ra).
PF-4191834；化合物PF-4191834PF-04191834；PF-04191834 (2024/9/1)
简介：pf-4191834 is a noniron chelating and non-redox inhibitor of the 5-lipoxygenase (5-lox) with an ic50 of 229 nm. pf-4191834 shows ~300-fold selectivity for 5-lox over 12-lox and 15-lox and displays no activity toward the cyclooxygenase enzymes. pf-4191834
PF-3882845；化合物 T16502PF-3882845 (2024/9/1)
简介：pf-3882845 also binds to the progesterone receptor (the binding ic50: 310 nm). pf-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (mr binding ic50=2.7 nm) antagonist for hypertension and nephropathy.
PF-3644022；化合物PF-3644022PF-3644022 (2024/9/1)
简介：pf-3644022 is an effective, selective, and atp-competitive mapkapk2 (mk2) inhibitor (ic50: 5.2 nm and a ki of 3 nm). pf-3644022 potently inhibits tnfα production and has an anti-inflammatory effect. pf-3644022 also inhibits mk3 and p38 regulated/activated kinase (prak) (ic50s: 53 nm and 5.0 nm, respectively).
PF-3450074；化合物PF-3450074PF-74；PF-74 (2024/9/1)
简介：pf-3450074 (pf-74) acts at an early stage of hiv-1 infection inhibits viral replication by directly competing with the binding of cpsf6 (nuclear host factors cleavage and polyadenylation specific factor 6) and nup153 (nucleoporin 153), and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle. pf-3450074 is a specifical inhibitor of hiv-1 capsid protein (ca) and shows a broad-spectrum inhibition of hiv isolates with submicromolar potency (ec50=8-640 nm).
Chlorzoxazone；氯唑沙宗Paraflex|||Chlorzoxazon；Paraflex|||Chlorzoxazon|||氯唑沙宗 (2024/9/1)
简介：chlorzoxazone (chlorzoxazon) is a muscle relaxant. the physiologic effect of chlorzoxazone is by means of centrally-mediated muscle relaxation.
Mardepodect；化合物MardepodectPF-2545920；PF-2545920 (2024/9/1)
简介：mardepodect (pf-2545920) is a phosphodiesterase inhibitor selective for the pde10a subtype with an ic50 of 0.37 nm, >1000-fold selectivity over pde. it is potentially useful for the treatment of schizophrenia. phosphodiesterase 10a (pde10a) is highly expressed in striatal medium spiny neurons of both the direct and indirect output pathways. mardepodect can cross the blood-brain barrier.
α、β、γ表面污染测量仪 (2024/9/1)
简介：tsfj170p α、β表面污染仪为便携式放射性表面污染测量设备，采用 zns（ag）塑料闪烁体作为探测灵敏器件，主要用来检测放射性工作场所的地面、桌面等表面污染，以及工作人员的手、鞋、工作服等表面受到的污染。
PF 1022A化合物 T16497PF 1022A (2024/9/1)
简介：pf 1022a is an n-methylated cyclooctadepsipeptides with strong anthelmintic properties. it also acts as an ionosphere.
PF-06795071；化合物 T16496PF-06795071 (2024/9/1)
简介：pf-06795071 is an effective and selective covalent inhibitor of magl (ic50: 3 nm).
PF-06747711；化合物 T16495PF-06747711 (2024/9/1)
简介：pf-06747711 is an effective and selective retinoic acid receptor-related orphan c2 inverse agonist (ic50: 4.1 nm). pf-06747711 also has anti-skin inflammatory activity.
PF-06471553化合物 T16494PF 06471553|||PF06471553 (2024/9/1)
简介：pf-06471553 is an effective and selective inhibitor of monoacylglycerol acyltransferase 3 (ic50: 92 nm).
PF-06465469；化合物 T16493PF-06465469 (2024/9/1)
简介：pf-06465469 is a covalent itk inhibitor(ic50: 2 nm).
PF-06459988；化合物PF-06459988PF-06459988 (2024/9/1)
简介：pf-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (egfr) mutant inhibitor. pf-06459988 has high efficiency and high affinity for egfrs double mutants containing t790m, and has minimal activity against wt egfr. pf-06459988 makes a candidate drug for the treatment of cancer.
PF-06446846 hydrochloride；化合物PF-06446846盐酸盐PF-06446846 hydrochloride (2024/9/1)
简介：pf-06446846 hydrochloride, an orally active and highly selective inhibitor, targets proprotein convertase subtilisin/kexin type 9 (pcsk9) translation by inducing ribosomal stalling at approximately codon 34, effectively suppressing pcsk9 expression.
PF-06380101；化合物 T16490Auristatin-0101|||Aur0101；Auristatin-0101|||Aur0101 (2024/9/1)
简介：pf-06380101 is an auristatin microtubule inhibitor and is a cytotoxic dolastatin 10 analogue. when compared to other synthetic auristatin analogues that are used in the preparation of adcs, pf-06380101 displays excellent potencies in tumor cell proliferation assays and differential adme properties.
Tenofovir；替诺福韦PMPA|||TDF|||GS 1278；替诺福韦|||泰诺福韦|||PMPA|||TDF|||GS 1278 (2024/9/1)
简介：tenofovir (gs 1278) is an adenine analog reverse transc-riptase inhibitor with antiviral activity against hiv-1 and hepatitis b. it is used to treat hiv infections and chronic hepatitis b, in combination with other antiviral agents, due to the emergence of antiviral drug resistance when it is used alone.
Darigabat；化合物 DarigabatCVL-865|||PF-6372865|||PF-06372865；CVL-865|||PF-6372865|||PF-06372865 (2024/9/1)
简介：darigabat (pf-06372865) is an orally active and selective gabaa receptor modulator that crosses the blood-brain barrier and exhibits anxiolytic activity, with ki values of 2.9 nm, 21 nm, and 134 nm for α2, α1 pam, and α2 pam, respectively.darigabat is used in the study of anxiety disorders and epilepsy.
PF-06263276；化合物 T16488PF-06263276 (2024/9/1)
简介：pf-06263276 is an effective and selective inhibitor of pan-jak. it also has ic50s of 2.2 nm, 23.1 nm, 59.9 nm and 29.7 nm for jak1, jak2, jak3, and tyk2, respectively.
PF-05241328；化合物 T16487PF-05241328 (2024/9/1)
简介：pf-05241328 is an effective and selective inhibitor of human nav1.7 voltage-dependent sodium channels (ic50: 31 nm).
Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD；化合物PF-05231023PF-05231023；PF-05231023 (2024/9/1)
简介：mal-amido-peg2-c2-amido-ph-c2-co-azd (pf-05231023) is a long-acting fibroblast growth factor 21 (fgf21) analog and is an fgf21-receptor agonist. it is also suitable for development as a potential treatment for t2dm.
PF-05198007；化合物 T16485PF-05198007 (2024/9/1)
简介：pf-05198007 is a compound with a similar pharmacodynamic profile to pf-05089771. pf-05198007 is an effective and selective arylsulfonamide nav1.7 inhibitor.
PF-05180999；化合物 T16484PF-05180999 (2024/9/1)
简介：pf-05180999 is an inhibitor of phosphodiesterase 2a (ic50: 1.6 nm).
PF-05105679；化合物PF-05105679PF-05105679 (2024/9/1)
简介：pf-05105679 is a selective trpm8 antagonist (ic50 = 103 nm). pf-05105679 can be used in research on cold-related pain.
PF-05085727；化合物 T16482PF-05085727 (2024/9/1)
简介：pf-05085727 inhibits pde2a >4,000-fold selectivity over pde1 and pde3-11. pf-05085727 is an effective, selective and brain penetrant inhibitor of cgmp-dependent pde2a (ic50=2 nm) .
PF-04995274；化合物PF-04995274PF-04995274 (2024/9/1)
简介：pf-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-ht4r) agonist. pf-04995274 is brain penetrant and can be used for cognitive disorders associated with alzheimer´s disease. pf-04995274 has an ec50 range of 0.26-0.47 nm for human 5-ht4a/4b/4d/4e (ki range of 0.15-0.46 nm). it also has an ec50 range of 0.59-0.65 nm for rat 5-ht4s/4l/4e (ki of 0.30 nm for rat 5-ht4s).
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