9月
Voclosporin；伏环孢素ISAtx-247；ISAtx-247 (2024/9/1)
简介：voclosporin (isatx-247) is a novel and orally available calcium-modulated phosphatase (cn; pp2b) inhibitor and immunosuppressant for the treatment of lupus nephritis.
VI 16832；化合物 T17234VI 16832 (2024/9/1)
简介：vi 16832 is a broad spectrum type i kinase inhibitor. it also used for the comparative expression analysis of protein kinases in different cancer cell lines.
Vipivotide tetraxetan Linker；化合物 T17233PSMA-617 Linker；PSMA-617 Linker (2024/9/1)
简介：vipivotide tetraxetan linker (psma-617 linker) is a noncleavable peptide linker utilized in the synthesis of vipivotide tetraxetan (psma-617), a ligand instrumental in producing 177lu-psma-617. this radioactive molecule is applied in the treatment of prostate cancer[1].
Vidupiprant；化合物VidupiprantAMG 853；AMG 853 (2024/9/1)
简介：vidupiprant (amg 853) is an effective dual antagonist of crth2 and prostanoid d receptor with ic50s of 8 nm and 35 nm in human plasma. vidupiprant can be used in studies about the treatment of asthma.
Vicagrel；维卡格雷Vicagrel (2024/9/1)
简介：vicagrel is an effective, orally active antiplatelet compound that enhances the inhibitory effect of aspirin on platelet aggregation and thrombosis in rodents by irreversibly inhibiting p2y12 receptors and reducing metabolic inactivation. viagrel can be used to treat blood clots in coronary artery disease, peripheral vascular disease and cerebrovascular disease.
VH032-PEG3-acetylene；化合物 T17230VH032-PEG3-acetylene (2024/9/1)
简介：vh032-peg3-acetylene is a synthesized conjugate compound consisting of a vh032-based vhl ligand and a linker, designed for use in protac technology as an e3 ligase ligand-linker conjugate[1].
Verubulin化合物 T17229MPC 6827 (2024/9/1)
简介：verubulin is a microtubule-disrupting agent with potent and broad-spectrum in vitro and in vivo cytotoxic activities.
Sabizabulin；化合物SabizabulinABI-231|||VERU-111；ABI-231|||VERU-111 (2024/9/1)
简介：sabizabulin (abi-231) is an effective and orally bioavailable inhibitor of α and β tubulin against panels of melanoma and prostate cancer cell lines. sabizabulin inhibits tumor growth and metastatic phenotypes of cervical cancer cells via targeting hpv e6 and e7. sabizabulin shows antiproliferative activity and can be used in prostate cancer studies.
Vernakalant Hydrochloride；盐酸维那卡兰RSD1235 hydrochloride；RSD1235 hydrochloride (2024/9/1)
简介：vernakalant hydrochloride (rsd1235 hydrochloride) is a mixed voltage- and frequency-dependent na+ and atria-preferred k+ channel blocker.
Vericiguat；维利西呱BAY1021189；维利西呱|||BAY1021189 (2024/9/1)
简介：vericiguat (bay1021189) is a potent and orally available guanylate cyclase stimulator.
Vercirnon；维塞诺CCX282-B|||GSK-1605786|||Traficet-EN；CCX282-B|||维塞诺|||GSK-1605786|||Traficet-EN (2024/9/1)
简介：vercirnon (traficet-en) is a selective and potent antagonist of ccr9 (ic50: 10 nm). it is also used in the research of inflammatory bowel diseases.
VER-246608；化合物VER-246608VER-246608 (2024/9/1)
简介：ver-246608 is an effective and atp-competitive inhibitor of pyruvate dehydrogenase kinase (ic50s: 35 nm, 40 nm, 84 nm, and 91 nm for pdk-1, pdk-3, pdk-2, and pdk-4, respectively).ver-246608 disrupts warburg metabolism and induces context-dependent cytostasis in cancer cells. consistent with a pdk mediated moa, ver-246608 increased pyruvate dehydrogenase complex (pdc) activity, oxygen consumption and attenuated glycolytic activity. ver-246608 was found to potentiate the activity of doxorubicin.
VER-00158411；化合物 T17223VER-00158411 (2024/9/1)
简介：ver-00158411 is a checkpoint kinase 1 and chk2 inhibitor (ic50: 4.4 nm and 4.5 nm, respectively).
Velneperit；韦利贝特S2367；韦利贝特|||S2367 (2024/9/1)
简介：velneperit (s2367) is potent and selective neuropeptide y (npy) y5 receptor under evaluating for treatment of obesity.
Velagliflozin；化合物 T17221Velagliflozin (2024/9/1)
简介：velagliflozin is an orally available inhibitor of sodium-glucose cotransporter 2.
Vecabrutinib；维卡布鲁替尼SNS-062；SNS-062 (2024/9/1)
简介：vecabrutinib (sns-062) is a potent and noncovalent btk and itk inhibitor (kd: 0.3 nm and 2.2 nm, respectively). vecabrutinib displays an ic50 of 24 nm for itk.
5-Amino-4-imidazolecarboxamide；5-氨基-1H-咪唑-4-酰胺5-Amino-4-imidazolecarboxamide (2024/9/1)
简介：5-amino-4-imidazolecarboxamide is an imidazole derivative.
Vatalanib free base；瓦他拉尼碱Vatalanib free base (2024/9/1)
简介：vatalanib is a vegfr2/kdr inhibitor (ic50: 37 nm).
Varespladib methyl；化合物Varespladib methylA-002|||LY333013；A-002|||LY333013 (2024/9/1)
简介：varespladib methyl (ly333013), a bioavailable prodrug of varespladib, is a selective group ii secretory phospholipase a2 inhibitor.
Vamorolone；地塞米松EP杂质EVBP15；地塞米松EP杂质E|||VBP15 (2024/9/1)
简介：vamorolone (vbp15) is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. vamorolone improves muscular dystrophy without side effects. vamorolone displays effective nf-κb inhibition and substantially decreases hormonal effects.
Valspodar；伐司扑达PSC 833；PSC 833 (2024/9/1)
简介：valspodar (psc 833) is a specific p-glycoprotein inhibitor and mdr regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.
Valnoctamide化合物 T17215Valmethamide (2024/9/1)
简介：valnoctamide inhibits benzodiazepine-refractory status epilepticus. valnoctamide acts directly on gabaa receptors.
Valencene；凡伦橘烯(NSC 148969|||NSC-148969|||NSC148969；NSC 148969|||NSC-148969|||NSC148969 (2024/9/1)
简介：valencene (nsc-148969) is a sesquiterpenoid isolated from cyperus rotundus and is an aroma component of citrus fruits and citrus-derived odors.valencenevalencene has anti-allergic, anti-inflammatory, anti-melanogenic, and antioxidant activities. valencene inhibits the overexpression of th2 chemokines and pro-inflammatory chemokines by blocking the nf-κb pathway.
Val-cit-PAB-OH；化合物Val-cit-PAB-OHVal-cit-PAB-OH (2024/9/1)
简介：val-cit-pab-oh is an adc linker that is cleavable.
VAL-083；去水卫矛醇Dianhydrogalactitol|||Dianhydrodulcitol；1,2:5,6-二脱水半乳糖醇|||Dianhydrogalactitol|||去水卫矛醇|| (2024/9/1)
简介：val-083 (dianhydrogalactitol) is an alkylating compound that creates n7 methylation on dna. it also has antitumor activity.
Vafidemstat；化合物 VafidemstatORY-2001；ORY-2001 (2024/9/1)
简介：vafidemstat (ory-2001) is a selective, orally active lysyl-histone demethylase (lsd1)/mao-b inhibitor that crosses the blood-brain barrier for the study of neurological diseases.
(3R,6R)-Vaborbactam(3R,6R)-法硼巴坦(3R,6R)-RPX7009|||(3R,6R)-Vaborbactam (Iso-1360457-46-0) (2024/9/1)
简介：(3r,6r)-vaborbactam ((3r,6r)-vaborbactam (iso-1360457-46-0)) is a cyclic boronic acid pharmacophore β-lactamase inhibitor with potential antimicrobial activity. (s)-vamicamide ((s)-vamicamide (iso-132373-81-0)) is a novel anticholinergic compound.
Vaborbactam ammonium salt；法硼巴坦铵盐RPX7009 ammonium salt|||Vaborbactam ammonium salt（1360457-46-0 Free (2024/9/1)
简介：vaborbactam ammonium salt is a β-lactamase inhibitor that restores carbapenem activity against kpc-producing strains and is often used in conjunction with other drugs to study fungal infections.
Vaborbactam；法硼巴坦RPX7009；RPX7009 (2024/9/1)
简介：vaborbactam (rpx7009) is a β-lactamase inhibitor that is often used in conjunction with meropenem to study pneumonia and cre infections.
Amfenac；化合物 T1720LNSC309467|||NSC-309467|||NSC 309467；NSC309467|||NSC-309467|||NSC 309467 (2024/9/1)
简介：amfenac promotes apoptosis in arpe-19 cell culture.
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