9月
Lurasidone hydrochloride；盐酸鲁拉西酮Lurasidone HCl|||SM-13496 (Hydrochloride)|||SM-13496；Lurasidone HCl|| (2024/9/1)
简介：lurasidone hydrochloride (lurasidone hcl) is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine d2 receptor antagonist; serotonin 5-ht2 receptor antagonist, serotonin 5-ht7 receptor antagonist, an antagonist of the adrenergic α2a and α2c receptors, as well as a partial serotonin 5-ht1a receptor agonist. it is used in the treatment of schizophrenia and bipolar disorder.
Rizatriptan化合物 T1734LMK 462 free base|||Risatriptan (2024/9/1)
简介：rizatriptan is an agonist of the serotonin-1b and serotonin-1d receptor.
Ac4GlcNAlk；化合物 T17349Ac4GlcNAlk (2024/9/1)
简介：ac4glcnalk is a alkyl chain-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Ac4GalNAz；化合物Ac4GalNAzAc4GalNAz (2024/9/1)
简介：ac4galnaz is an alkyl chain-based protac linker that can be used in protac synthesis.
9-Decyn-1-ol；化合物 T173469-Decyn-1-ol (2024/9/1)
简介：9-decyn-1-ol is an alkyl/ether-based protac linker suitable for synthesizing protacs. it serves as a conjugation agent to combine gdc-0068 and lenalidomide, resulting in the formation of iny-03-041. iny-03-041 is a potent and highly selective pan-akt degrader that operates through the protac mechanism. it effectively inhibits akt1, akt2, and akt3 with ic50 values of 2.0 nm, 6.8 nm, and 3.5 nm, respectively[1].
7-Octynoic acid；化合物 T173457-Octynoic acid (2024/9/1)
简介：7-octynoic acid (compound 42) serves as a protac linker for synthesizing various protacs, which are composed of two distinct ligands joined by this linker. one ligand interacts with an e3 ubiquitin ligase, while the other binds to the target protein. by leveraging the intracellular ubiquitin-proteasome system, protacs selectively degrade target proteins[1].
7-O-(Cbz-N-amido-PEG4)-paclitaxel；化合物 T173447-O-(Cbz-N-amido-PEG4)-paclitaxel (2024/9/1)
简介：7-o-(cbz-n-amido-peg4)-paclitaxel is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
7-O-(Amino-PEG4)-paclitaxel；化合物 T173437-O-(Amino-PEG4)-paclitaxel (2024/9/1)
简介：7-o-(amino-peg4)-paclitaxel is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
6-O-2-Propyn-1-yl-D-galactose；化合物 T173426-O-2-Propyn-1-yl-D-galactose (2024/9/1)
简介：6-o-2-propyn-1-yl-d-galactose functions as an irreversible glycolinker, facilitating the attachment of cytotoxic drugs for applications in antibody-drug conjugation.
5-endo-BCN-pentanoic acid；化合物 T173405-endo-BCN-pentanoic acid (2024/9/1)
简介：5-endo-bcn-pentanoic acid, an alkyl chain-based protac linker, facilitates the synthesis of protacs[1].
Rabeprazole Sulfide；雷贝拉唑相关物质ERabeprazole Related Compound E；雷贝拉唑相关物质E|||Rabeprazole Related Compound (2024/9/1)
简介：rabeprazole sulfide (rabeprazole related compound e) is an antiulcer drug in the class of proton pump inhibitors.
(5,6)TAMRA-PEG3-Azide-PEG3-Desthiobiotin；化合物 T17339(5,6)TAMRA-PEG3-Azide-PEG3-Desthiobiotin (2024/9/1)
简介：(5,6)tamra-peg3-azide-peg3-desthiobiotin is a polyethylene glycol (peg)-based protac linker utilized for the synthesis of protacs.
(4-Oxo-4H-quinazolin-3-yl)-acetic acid；化合物 T17338(4-Oxo-4H-quinazolin-3-yl)-acetic acid (2024/9/1)
简介：(4-oxo-4h-quinazolin-3-yl)-acetic acid is an alkyl chain-derived protac linker suitable for the synthesis of protacs[1].
4-N3Pfp-NHS ester；化合物 T173374-N3Pfp-NHS ester (2024/9/1)
简介：4-n3pfp-nhs ester is a noncleavable adc linker utilized for synthesizing antibody-drug conjugates (adcs).
4-(N-Boc-amino)-1,6-heptanedioic acid；化合物 T173364-(N-Boc-amino)-1,6-heptanedioic acid (2024/9/1)
简介：4-(n-boc-amino)-1,6-heptanedioic acid is an alkyl/ether-based linker, suitable for protac synthesis [1].
4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid；化合物 T173354-Methyl-4-(pyridin-2-yldisulfanyl)penta (2024/9/1)
简介：4-methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid is a cleavable linker compound employed in the synthesis of antibody-drug conjugates (adcs)[1].
4-Methyl-4-(methyldisulfanyl)pentanoic acid；化合物 T173344-Methyl-4-(methyldisulfanyl)pentanoic acid (2024/9/1)
简介：4-methyl-4-(methyldisulfanyl)pentanoic acid is an adc linker employed in the synthesis of antibody-drug conjugates (adcs) that can be cleaved.
4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol；化合物 T173334-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol (2024/9/1)
简介：4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenol is an alkyl chain-derived protac linker employed for the synthesis of protacs[1].
3,4-Dibromo-Mal-PEG8-acid；化合物 T173323,4-Dibromo-Mal-PEG8-acid (2024/9/1)
简介：the compound 3,4-dibromo-mal-peg8-acid is a peg-based protac linker employed for protac synthesis[1].
(2-pyridyldithio)-PEG4 acid；化合物 T17331(2-pyridyldithio)-PEG4 acid (2024/9/1)
简介：(2-pyridyldithio)-peg4 acid is a four-unit cleavable polyethylene glycol (peg) linker specifically designed for the synthesis of antibody-drug conjugates (adcs)[1]. it serves as a crucial component in the conjugation of antibodies and drugs, enabling targeted drug delivery and enhanced therapeutic efficacy. this linker possesses a (2-pyridyldithio) group at one end, facilitating the attachment of the linker to the specific site on the antibody molecule. the peg4 chain provides the necessary flex
2-Phthalimidehydroxy-acetic acid；化合物2-Phthalimidehydroxy-acetic acid2-Phthalimidehydroxy-acetic acid (2024/9/1)
简介：2-phthalimidehydroxy-acetic acid is an alkyl chain-based protac linker that can be used in protac synthesis.
Ciprofloxacin EP IMpurity A；环丙羧酸Q-Acid|||Fluoroquinolonic Acid|||Ciprofloxacin Impurity A；Q-Acid|||F (2024/9/1)
简介：ciprofloxacin ep impurity a (fluoroquinolonic acid) is an antibiotic and antimicrobial agent.
2-Bromo-2,2-dimethyl-acetamido-PEG3-acid；化合物 T173292-Bromo-2,2-dimethyl-acetamido-PEG3-acid (2024/9/1)
简介：2-bromo-22-dimethyl-acetamido-peg3-acid is a polyethylene glycol (peg) derivative commonly employed as a peg-based protac linker during protac synthesis[1].
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid；化合物 T173282((AzidoPEG8carbamoyl)methoxy)acetic acid|||2 (2024/9/1)
简介：2-((azido-peg8-carbamoyl)methoxy)acetic acid is a polyethylene glycol (peg) derivative that serves as a linker for proteolysis targeting chimeras (protacs) synthesis [1].
2-(Azido-PEG3-amido)-1,3-bis(NHS ester)；化合物 T173272-(Azido-PEG3-amido)-1,3-bis(NHS ester) (2024/9/1)
简介：2-(azido-peg3-amido)-1,3-bis(nhs ester) is a polyethylene glycol (peg)-based linker for protac synthesis [1].
2,3,4,6-Tetra-o-acetyl-alpha-galactosylpyranosyl bromide；化合物T173262-3-4-6-tetra-o-acetyl-alpha-galac (2024/9/1)
简介：2,3,4,6-tetra-o-acetyl-alpha-galactosylpyranosyl bromide (2-3-4-6-tetra-o-acetyl-alpha-galactosylpyranosyl-bromide) is an alkyl chain-based protac linker that can be used in protac synthesis.
Pomalidomide-PEG4-C-COOH；化合物Pomalidomide-PEG4-C-COOHCereblon Ligand -Linker Conjugates 1|||E3 Ligase (2024/9/1)
简介：pomalidomide-peg4-c-cooh (e3 ligase ligand-linker conjugates 1) is a synthesized e3 ligase ligand-linker conjugate that combines the pomalidomide-based cereblon ligand and 4-unit peg linker used in protac technology.
11-Maleimidoundecanoic acid；11-马来酰胺基十一烷酸11-Maleimidoundecanoic acid (2024/9/1)
简介：11-maleimidoundecanoic acid is an alkyl chain-based protac linker that can be used in protac synthesis.
11-Aminoundecanoic acid；11-氨基十一酸11-Aminoundecanoic acid (2024/9/1)
简介：11-aminoundecanoic acid is an alkyl chain based protac linker can be used in protac synthesis.
1-(Isopropylthio)-2,3,4,6-tetra-o-Ac-beta-D-glucosylpyranose；化合物 T173221-(Isopropylthio)-2,3,4,6-tet (2024/9/1)
简介：1-(isopropylthio)-2,3,4,6-tetra-o-ac-beta-d-glucosylpyranose is an alkyl chain-derived protac linker utilized in the synthesis of protacs[1].
MSN交谈
