9月
UVI 3003；化合物UVI 3003UVI 3003 (2024/9/1)
简介：uvi 3003 is a highly selective antagonist of the retinoid x receptor. uvi 3003 inhibits xenopus and human rxrα in cos7 cells (ic50s: 0.22 and 0.24 μm, respectively).
USL311；化合物USL311USL311 (2024/9/1)
简介：usl311 is a cxcr4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (sdf-1 or cxcl12) to cxcr4. usl311 inhibits cxcr4 activation and decreases proliferation and migration of cxcr4-expressing tumor cells, with anti-tumor activity.
UPGL00004；化合物UPGL00004UPGL00004 (2024/9/1)
简介：upgl00004 is a potent glutaminase c (gac) inhibitor with an ic50 of 29 nm. kd of upgl00004 for gac was 27 nm. upgl00004 has a strong inhibitory effect on the proliferation of highly aggressive triple negative breast cancer cell lines.
UNC2541；化合物UNC2541UNC2541 (2024/9/1)
简介：unc2541 is a potent and mer tyrosine kinase (mertk)-specific inhibitor. it also binds in the mertk atp pocket (ic50: 4.4 nm). unc2541 inhibits phosphorylated mertk (pmertk; ec50, 510 nm).
UNC0321；化合物UNC0321UNC0321 (2024/9/1)
简介：unc0321 is an effective inhibitor of histone methyltransferase g9a with a ki of 63 pm and with ic50s 9 nm and 6 nm in ecsd and clot assays. unc0321 inhibits glp with ic50s of 15 nm and 23 nm in ecsd and clot assays.
UNC0224；化合物UNC0224UNC0224 (2024/9/1)
简介：unc0224 is a selective inhibitor of g9a with a ki of 2.6 nm and ic50 of 15 nm. unc0224 also potently inhibits glp with assay-dependent ic50 values of 20-58 nm.
Ulimorelin；化合物 T17202TZP-101；TZP-101 (2024/9/1)
简介：ulimorelin is a ghrelin receptor agonist (ec50: 29 nm and a ki of 16 nm). ulimorelin is a prokinetic agent and causes vasorelaxation through competitive antagonist action at α1-adrenoceptors.
UK 356618化合物 T17201UK 356618 (2024/9/1)
简介：uk 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (ic50: 5.9 nm).
UDM-001651；化合物 T17200UDM-001651 (2024/9/1)
简介：udm-001651 is an effective and orally bioavailable protease-activated receptor 4 antagonists (ic50=4 nm; kd=1.4 nm). udm-001651 displays antiplatelet potency (ic50=25 nm) in a γ-thrombin-induced platelet-rich plasma aggregation assay.
Amfenac Sodium Hydrate；氨芬酸钠水合物Amfenac Sodium Monohydrate；一水氨芬酸钠|||Amfenac Sodium Monohydrate|||氨芬酸钠水 (2024/9/1)
简介：amfenac sodium hydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety.
Udenafil乌地那非3-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑并[4,3-D]嘧啶-5-基)-N-[2-(1-甲基-2-吡咯烷基)乙基]-4-丙氧基苯磺酰胺|||乌地那非 (2024/9/1)
简介：udenafil is an inhibitor of pde5 .
UCL 2077；化合物UCL 2077UCL 2077 (2024/9/1)
简介：ucl 2077 is a subtype-selective blocker of the epilepsy-associated kcnq channels and it also is a selective slow-afterhyperpolarization channel blocker，with ic50 of 500 nm in hippocampal neurons in culture, having minimal effects on ca2+ channels, action potentials, input resistance, and the medium afterhyperpolarization.
UC-1728；化合物UC-1728t-TUCB；t-TUCB (2024/9/1)
简介：uc-1728 (t-tucb) is an effective rabbit soluble epoxide hydrolase inhibitor (ic50: 2 nm on rabbit liver).
UC-112；化合物UC-112UC-112 (2024/9/1)
简介：uc-112 is a novel potent iap inhibitor and potently inhibits cell growth in two human melanoma and two human prostate cancer cell lines (ic50=0.7-3.4 um).
Ubrogepant；化合物UbrogepantMK-1602；MK-1602 (2024/9/1)
简介：ubrogepant (mk-1602) is an antagonist of calcitonin gene-related peptide receptor that can be used in the acute treatment of migraine studies.
UBP 302；化合物 T17193UBP 302 (2024/9/1)
简介：ubp 302 is an effective and selective gluk5-subunit-containing kainate receptor antagonist (apparent kd=402 nm) and displays very little affinity on gluk2 kainate receptors.
Ubiquitin Isopeptidase Inhibitor I, G5；Ubiquitin Isopeptidase 抑制剂INSC144303；NSC144303 (2024/9/1)
简介：ubiquitin isopeptidase inhibitor i, g5 is a caspase-independent inducer of cell necrosis that induces cell death via the death receptor pathway (ic50 of 1.76 and 1.6 μm in e1a and e1a/c9dn cells, respectively).
Bunaprolast；布那司特U66858；U66858 (2024/9/1)
简介：bunaprolast (u66858) is a novel and potent leukotriene b4 (ltb4) inhibitor.bunaprolast exhibits oxidative degradation activity and inhibits lipoxygenase and txb2 release.
U18666A；化合物U18666AU18666A (2024/9/1)
简介：u18666a is a cell-permeable drug and is a cholesterol synthesis and transport inhibitor. it inhibits replication of ebola virus, dengue virus, and human hepatitis c virus.
Bufalin；蟾毒灵Bufalin (2024/9/1)
简介：bufalin is an active ingredient and one of the glycosides in the traditional chinese medicine chansu; it is also a bufadienolide toxin originally isolated from the venom of the chinese toad bufo gargarizans, with potential cardiotonic and antineoplastic activity. although the mechanism of action of bufalin is still under investigation, this agent is a specific na+/k+-atpase inhibitor and can induce apoptosis in y cell lines through the activation of the transcription factor ap-1 via a mitogen ac
U-46619；化合物U-466199,11-Methanoepoxy PGH2；9,11-Methanoepoxy PGH2 (2024/9/1)
简介：u-46619 is an effective thromboxane a2 (txa2) agonist and a thromboxane a2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (sm) of mice with a myosin light chain 9 (myl9) gene deletion.
U-101017；化合物 T17188PNU 101017；PNU 101017 (2024/9/1)
简介：u-101017 is a partial benzodiazepine receptor and gabaa receptor agonist.
TZ9；化合物TZ9TZ9 (2024/9/1)
简介：tz9 is a selective and potent rad6 inhibitor with anticancer and anti-tumor activity.tz9 inhibits rad6b-induced ubiquitination of histone h2a.tz9 induces cell cycle arrest and apoptosis.
TY-51469；化合物TY-51469TY-51469 (2024/9/1)
简介：ty-51469 is an inhibitor of chymase (ic50s for simian and human chymases: 0.4 and 7.0 nm, respectively).
Tyrothricin；酪丝菌素Tyrothricin (2024/9/1)
简介：tyrothricin is a polypeptide antibiotic mixture isolated from bacillus brevis and consists of tyrocidines and gramicidins. tyrothricin displays activity against bacteria, fungi, and some viruses.
Tyrosine kinase inhibitor；化合物Tyrosine kinase inhibitorTyrosine kinase inhibitor (2024/9/1)
简介：tyrosine kinase inhibitor is a tyrosine kinase inhibitor used in combination with fragmenting aromatic nitrogen compounds as antiproliferative agents.
TY-52156；化合物TY-52156TY-52156 (2024/9/1)
简介：ty-52156 is an effective and selective s1p3 receptor antagonist (ki: 110 nm).
TX1-85-1；化合物TX1-85-1TX1-85-1 (2024/9/1)
简介：tx1-85-1 induces partial degradation of her3 protein and attenuates her3-dependent signaling. tx1-85-1 is an irreversible her3 inhibitor (ic50: 23 nm). tx1-85-1 is also the first selective her3 ligand, which forms a covalent bond with cys721 located in the atp-binding site of her3.
TVB-3664；化合物TVB-3664TVB-3664 (2024/9/1)
简介：tvb-3664 significantly decreases tubulin palmitoylation and mrna expression. tvb-3664 is a reversible and highly bioavailable fatty acid synthase inhibitor (ic50: 18 nm and 12 nm for human and mouse cell palmitate synthesis, respectively).
TVB-3166；化合物TVB-3166TVB-3166 (2024/9/1)
简介：tvb-3166 induces apoptosis and inhibits in-vivo xenograft tumor growth. tvb-3166 is a reversible and selective fatty acid synthase inhibitor (ic50s: 42 nm and 81 nm for biochemical fasn and cellular palmitate synthesis, respectively).
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