9月
Xantocillin；黄青霉素Xantocillin (2024/9/1)
简介：xanthocillin is a marine agent. xanthocillin also induces autophagy through inhibition of the mek/erk pathway.
WWL70；化合物WWL70WWL70 (2024/9/1)
简介：wwl70 is a selective alpha/beta hydrolase domain 6 inhibitors (ic50: 70 nm).
SB-431542；化合物SB 431542SB 431542；4-[4-(1,3-苯并二唑-5-基)-5-(2-吡啶基)-1H-咪唑-2-基]-苯酰胺水合物|||SB 431542 (2024/9/1)
简介：sb-431542 is an inhibitor of alk5/tgf-β type i receptor (ic50=94 nm) and is selective. sb 431542 also has inhibitory activity against alk4 and alk7 but not other proteins. sb 431542 can be used for induced differentiation of stem cells.
WWL113；化合物 T17259WWL113 (2024/9/1)
简介：wwl113 is a selective and orally active ces3 and ces1f inhibitor (ic50: 120 nm and 100 nm for ces3 and ces1f, respectively). wwl113 appears to display excellent selectivity for the 60-kda serine hydrolase.
WRG-28；化合物WRG-28WRG-28 (2024/9/1)
简介：wrg-28 is a potent and selective, allosteric discoidin domain receptor 2 (ddr2) inhibitor(ic50 : 230 nm)
WR99210 hydrochloride(47326-86-3 free base)；化合物WR99210 hydrochlorideWR99210 hydrochloride(47326-86-3 (2024/9/1)
简介：wr99210 hydrochloride is a potent inhibitor of plasmodium falciparum dihydrofolate reductase (pfdhfr), which is a major malarial drug target. it has subnanomolar potency for the wild type, double mutant and quadruple mutant dihydrofolate reductases.
WR99210化合物WR99210Antifolate|||Inhibitor|||Bacterial (2024/9/1)
简介：wr99210 is a potent, orally available and less toxic dihydrofolate reductase (dhfr) inhibitor (ic50<0.075 nm). wr99210 has good antiparasitic activity against p. vivax and p. falciparum strains (including p. falciparum strains resistant to pyrimethamine ) and t. gondii.
Wnt pathway activator 1；化合物Wnt pathway activator 1Wnt pathway activator 1 (2024/9/1)
简介：wnt pathway activator 1 is a potent wnt activator with an ic50 of 28-29 nm. wnt pathway activator 1 is a potent wnt activator for the treatment of androgenetic alopecia (aga).
WJ460；化合物WJ460WJ460 (2024/9/1)
简介：wj460 is an effective inhibitor of myoferlin. wj460 exerts anti-metastatic activity in breast cancer cells.
Amifloxacin；氨氟沙星Win49375；Win49375|||氨氟沙星 (2024/9/1)
简介：amifloxacin (win49375) is a synthetic antibacterial compound and showed moderate activity against staphylococcus aureus, with mics of less than or equal to 2 micrograms/ml.
WAY 163909；化合物 T17253WAY 163909 (2024/9/1)
简介：way 163909 is an effective and selective agonist of the 5-ht(2c) receptor (ki: 10.5±1.1 nm).
SIM-688；化合物 SIM-688SIM688；SIM688 (2024/9/1)
简介：sim-688 is a selective and orally active estrogen receptor inhibitor of nf-κb transcriptional activity (ic50 = 122 nm in haect-1 cells).
VNA-932；化合物 VNA-932WAY-VNA 932；WAY-VNA 932 (2024/9/1)
简介：vna-932 is an agonist of the vasopressin v2-receptor (ic50: 80.3 nm and 778 nm in human-v2 binding and v1a binding assay).
W-54011；化合物W-54011W-54011 (2024/9/1)
简介：w-54011 is a potent non-peptide c5a receptor antagonist. w-54011 inhibits the binding of 125i-labeled c5a to human neutrophils (ki = 2.2 nm). w-54011 inhibits c5a-induced intracellular ca2+ mobilization, chemotaxis, and generation of ros in human neutrophils (ic50s = 3.1 nm, 2.7 nm, and 1.6 nm, respectively).
Y-27632 dihydrochloride；化合物Y-27632 dihydrochlorideY-27632 2HCl；反式-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐 (2024/9/1)
简介：y-27632 dihydrochloride (y-27632 2hcl) is an orally potent, atp-competitive inhibitor of rock-i and rock-ii. y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
VZ185；化合物 T17249VZ185 (2024/9/1)
简介：vz185 is an effective and selective dual brd7/9 protac degrader (dc50s: 4.5 and 1.8 nm, respectively).
VU6001376；化合物 T17248VU6001376 (2024/9/1)
简介：vu6001376 is an effective and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (ec50: 50.1 nm).
VU0661013；化合物VU0661013VU661013；VU661013 (2024/9/1)
简介：vu0661013 is an effective and selective inhibitor of mcl-1.
VU0529331；化合物 T17246VU0529331 (2024/9/1)
简介：vu0529331 is a modestly selective non-girk1-containing g protein-gated, inwardly-rectifying, potassium channel activator (ec50s: 5.1 μm and 5.2 μm for girk2 and girk1/2 in hek293 cells, respectively). it is also effective on the girk4 homomeric channel.
VU0467485化合物 T17245AZ13713945 (2024/9/1)
简介：vu0467485 is a potent and selective muscarinic acetylcholine receptor 4 positive allosteric modulator. vu0467485 potentiates the activity of ach at m4 (ec50s: 26.6 nm and 78.8 nm at the rat and human m4 receptors, respectively). vu0467485 displays selectivity for m4 over human and rat m1/2/3/5.
VU0467154；化合物VU0467154VU0467154 (2024/9/1)
简介：vu0467154 is a positive allosteric modulator of the m4 muscarinic acetylcholine receptor.
VU0463271；化合物VU0463271N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetami (2024/9/1)
简介：vu0463271 (n-cyclopropyl-n-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide) is a potent and selective antagonist of the neuronal-specific potassium-chloride cotransporter 2 (kcc2), with an ic50 of 61 nm and >100-fold selectivity versus the closely related na-k-2cl cotransporter 1 (nkcc1) and no activity in a larger panel of gpcrs, ion channels, and transporters.
VU0453379；化合物 T17242VU0453379 (2024/9/1)
简介：vu0453379 is a highly selective and central nervous system penetrant positive allosteric modulator of glucagon-like peptide-1r (ec50: 1.3 μm).
Auglurant；化合物 T17241VU0424238；VU0424238 (2024/9/1)
简介：auglurant is a novel and selective mglu5 antagonist (ic50: 11 nm (rat) and an ic50: 14 nm (human)). auglurant has an acceptable cns penetration.
VU041；化合物 T17240VU041 (2024/9/1)
简介：vu041 is an inhibitor of anopheles gambiae and aedes aegypti inward rectifier potassium 1 channels (ic50: 2.5 μm and 1.7 μm, respectively). vu041 inhibits appreciably is mammalian kir2.1 (ic50: 12.7 μm) and has less inhibitory effect on mammalian kir1.1, kir4.1, kir6.2/sur1, and kir7.1.
SCR7 pyrazine；SCR7 吡嗪SCR7；SCR7|||SCR7 吡嗪 (2024/9/1)
简介：scr7 pyrazine (scr7) enhances crispr-cas9-mediated homology-directed repair (hdr) efficiency in vitro up to 19-fold. inhibits nonhomologous end-joining (nhej).
VU0155069；化合物VU0155069CAY10593；CAY10593 (2024/9/1)
简介：vu0155069 strongly inhibits the invasive migration of several cancer cell lines in transwell assays. vu0155069 is a selective phospholipase d1 inhibitor (ic50: 46 nm in vitro).
VU0152100；化合物VU0152100VU152100；VU152100 (2024/9/1)
简介：vu0152100 is an effective and selective allosteric potentiator of m4 machr (ec50: 380 ± 93 nm).
VPC 23019；化合物VPC 23019VPC 23019 (2024/9/1)
简介：vpc 23019 is a competitive antagonist at the s1p1 and s1p3 receptors (pki= 7.86 and 5.93, respectively). it is also an agonist at the s1p4 and s1p5 receptors (pec50= 6.58 and 7.07, respectively).
Volixibat；化合物 T17236SHP626|||LUM002；SHP626|||LUM002 (2024/9/1)
简介：volixibat is a highly selective and competitive apical sodium-dependent bile acid transporter inhibitor. volixibat has the potential for treatment for non-alcoholic steatohepatitis.
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