9月
Ald-Ph-PEG5-Boc；化合物 T17377Ald-Ph-PEG5-Boc (2024/9/1)
简介：ald-ph-peg5-boc is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Ald-Ph-PEG24-TFP ester；化合物 T17376Ald-Ph-PEG24-TFP ester (2024/9/1)
简介：ald-ph-peg24-tfp ester is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Ald-Ph-PEG24-NHS ester；化合物 T17375Ald-Ph-PEG24-NHS ester (2024/9/1)
简介：ald-ph-peg24-nhs ester is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Ald-Ph-PEG2-Boc；化合物 T17374Ald-Ph-PEG2-Boc (2024/9/1)
简介：ald-ph-peg2-boc is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Ald-Ph-PEG12-TFP ester；化合物 T17373Ald-Ph-PEG12-TFP ester (2024/9/1)
简介：ald-ph-peg12-tfp ester is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Ald-Ph-NHS ester；对甲酰基苯甲酸N-羟基琥珀酰亚胺酯Ald-Ph-NHS ester (2024/9/1)
简介：ald-ph-nhs ester is a non-cleavable linker used in antibody-drug-conjugation (adc).
Ald-Ph-amido-PEG4-propargyl；化合物 T17371Ald-benzyl-amide-PEG4-propargyl；Ald-benzyl-amide-PEG4-propargy (2024/9/1)
简介：ald-ph-amido-peg4-propargyl is a non-cleavable 4-unit polyethylene glycol (peg) antibody-drug conjugate (adc) linker employed in adc synthesis[1].
Ald-Ph-amido-PEG24-acid；化合物 T17370Ald-Ph-amido-PEG24-acid (2024/9/1)
简介：ald-ph-amido-peg24-acid is a polyethylene glycol (peg)-based linker used for the synthesis of proteolysis targeting chimeras (protacs)[1].
Genistein；染料木素NPI 031L；NPI 031L|||三叶草|||染料木素|||金雀异黄酮 (2024/9/1)
简介：genistein (npi 031l) is an isoflavonoid derived from soy products. it inhibits protein-tyrosine kinase and topoisomerase-ii (dna topoisomerases, type ii), with antineoplastic and antitumor activities.
Ald-Ph-amido-PEG23-OPSS；化合物 T17369Ald-Ph-amido-PEG23-OPSS (2024/9/1)
简介：ald-ph-amido-peg23-opss is a cleavable 23-unit polyethylene glycol linker commonly employed for the synthesis of antibody-drug conjugates (adcs)[1].
Ald-Ph-amido-C2-PEG3-azide；化合物 T17368Ald-Ph-amido-C2-PEG3-azide (2024/9/1)
简介：ald-ph-amido-c2-peg3-azide is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Ald-CH2-PEG8-azide；化合物 T17367Ald-CH2-PEG8-azide (2024/9/1)
简介：ald-ch2-peg8-azide is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Ald-CH2-PEG10-Boc；化合物 T17366Ald-CH2-PEG10-Boc (2024/9/1)
简介：ald-ch2-peg10-boc is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Ala-Ala-Asn-PAB；化合物 T17365Ala-Ala-Asn-PAB (2024/9/1)
简介：ala-ala-asn-pab is a peptide cleavable adc linker for antibody-drug conjugates (adcs)[1].
AhR Ligand-Linker Conjugates 1；化合物 T17364E3 Ligase Ligand-Linker Conjugates 57；E3 Ligase Ligand-Link (2024/9/1)
简介：ahr ligand-linker conjugates 1, also known as e3 ligase ligand-linker conjugates 57, is a chemical compound that combines an iap ligand for the e3 ubiquitin ligase with a sniper linker. it is specifically designed to be used in the development of sniper[1].
β-Naphthoflavone-CH2-OH；化合物 T17363β-NF-CH2-OH；β-NF-CH2-OH (2024/9/1)
简介：β-naphthoflavone-ch2-oh (β-nf-ch2-oh) serves as an ahr e3 ligase ligand, forming chimeric molecules when connected to a protein ligand through a linker, resulting in protacs or snipers (e.g., β-naphthoflavone-jq1). these chimeric molecules recruit the ahr e3 ligase complex by incorporating ahr ligands. by inducing ubiquitination-mediated degradation, protacs effectively target and degrade cancer-promoting proteins [1].
Acrylate-PEG-OH (MW 5000)；化合物 T17362Acrylate-PEG-OH (MW 5000) (2024/9/1)
简介：acrylate-peg-oh (mw 5000) is a polyethylene glycol (peg)-based linker compound primarily utilized in protac synthesis[1].
Acrylate-PEG-OH (MW 3400)；化合物 T17361Acrylate-PEG-OH (MW 3400) (2024/9/1)
简介：acrylate-peg-oh (mw 3400) is a polyethylene glycol (peg) derived protac linker compound, which finds application in the synthesis of protacs[1].
Acrylate-PEG-OH (MW 10000)；化合物 T17360Acrylate-PEG-OH (MW 10000) (2024/9/1)
简介：acrylate-peg-oh (mw 10000) is a polyethylene glycol (peg) derived protac linker utilized for synthesizing protacs[1].
Apixaban阿哌沙班阿哌沙班|||BMS-562247-01 (2024/9/1)
简介：apixaban (bms-562247-01) is an orally active inhibitor of coagulation factor xa with anticoagulant activity. apixaban directly inhibits factor xa, thereby interfering with the conversion of prothrombin to thrombin and preventing the formation of cross-linked fibrin clots.
Acrylate-PEG-NH2 (MW 2000)；化合物 T17359Acrylate-PEG-NH2 (MW 2000) (2024/9/1)
简介：acrylate-peg-nh2 (mw 2000) is a polyethylene glycol (peg)-based proteolysis targeting chimera (protac) linker, employed for the synthesis of protacs [1].
Acrylate-PEG-NH2 (MW 10000)；化合物 T17358Acrylate-PEG-NH2 (MW 10000) (2024/9/1)
简介：acrylate-peg-nh2 (mw 10000) is a polyethylene glycol (peg)-based linker utilized in the synthesis of protacs[1].
AcLys-PABC-VC-Aur0101；化合物 T17357AcLys PABC VC Aur0101|||AcLys-PABC-VC-Aur-0101|||AcLysPABCVCAur0101| (2024/9/1)
简介：aclys-pabc-vc-aur0101 is a drug-linker conjugate for anti-cxcr4 adc with potent antitumor activity, comprising the auristatin microtubule inhibitor aur0101, connected through the cleavable linker aclys-pabc-vc[1].
Acid-propionylamino-Val-Cit-OH；化合物 T17356Acid-propionylamino-Val-Cit-OH (2024/9/1)
简介：acid-propionylamino-val-cit-oh is a cleavable linker commonly employed in the synthesis of antibody-drug conjugates (adcs)[1].
Acid-PEG4-S-PEG4-acid；化合物 T17355Acid-PEG4-S-PEG4-acid (2024/9/1)
简介：acid-peg4-s-peg4-acid is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Acid-PEG25-NHS ester；化合物 T17354Acid-PEG25-NHS ester (2024/9/1)
简介：acid-peg25-nhs ester is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Acid-PEG13-NHS ester；化合物 T17353Acid-PEG13-NHS ester (2024/9/1)
简介：acid-peg13-nhs ester is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Acid-C1-PEG5-Boc；化合物Acid-C1-PEG5-BocAcid-C1-PEG5-Boc (2024/9/1)
简介：acid-c1-peg5-boc is a peg-based protac linker that can be used in protac synthesis.
Acetylene-linker-Val-Cit-PABC-MMAE；化合物 T17351AcetylenelinkerValCitPABCMMAE|||LCB14-0602|||Acetylene (2024/9/1)
简介：acetylene-linker-val-cit-pabc-mmae (lcb14-0602) is a drug-linker conjugate for antibody-drug conjugates (adcs) that combines the adc linker (acetylene-linker-val-cit-pabc) with the potent tubulin inhibitor mmae.
ACBI1；化合物ACBI1ACBI1 (2024/9/1)
简介：acbi1 is a potent protac degrader of baf atpase subunits smarca2 and smarca4, also degrades the polybromo-associated baf (pbaf) complex member pbrm1, with dc50s of 6 nm, 11 nm and 32 nm for smarca2, smarca4 and pbrm1 in mv-4-11 cells, respectively. acbi1 is composed of a bromodomain ligand, a linker, and the e3 ubiquitin ligase vhl. acbi1 can induce anti-proliferative effects and apoptosis.
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