9月
Filorexant；化合物FilorexantMK-6096；MK-6096 (2024/9/1)
简介：filorexant (mk-6096) is an orally bioavailable effective and selective reversible antagonist of ox1 and ox2 receptor with (ki <3 nm).
MK-4256化合物 T16095MK 4256|||MK4256 (2024/9/1)
简介：mk-4256 is an effective and selective sstr3 antagonist (ic50s: 0.66 nm and 0.36 nm in human and mouse receptor binding assays, respectively).
MK-3328；化合物MK-3328MK-3328 (2024/9/1)
简介：mk-3328 has a high affinity for β-amyloid (ic50:10.5 nm), and can be used as a candidate pet ligand for clinical assessment of β-amyloid plaque load. mk-3328 is a potential treatment for alzheimer´s disease.
Telcagepant化合物 T16093MK-0974 (2024/9/1)
简介：telcagepant is an orally active antagonist of calcitonin gene-related peptide (cgrp) receptor (kis: 0.77 nm and 1.2 nm for human and rhesus cgrp receptors, respectively).
L-873724；化合物 T16092L-873724 (2024/9/1)
简介：l-873724 inhibits bone resorption. l-873724 is an effective, selective, and reversible non-basic cathepsin k inhibitor (ic50s: 0.2, 178, 264, and 5239 nm for cathepsin k, cathepsin s, cathepsin l, cathepsin b, respectively). l-873724 also shows an ic50 of 0.5 nm for rabbit cathepsin k.
MK-0812 Succinate；化合物MK-0812 SuccinateMK-0812 Succinate (2024/9/1)
简介：mk-0812 succinate is an effective and selective ccr2 antagonist.
MK-0773 FA；MK-0773 甲酸盐MK-0773 FA (606101-58-0 Free base)；MK-0773 FA (606101-58-0 Free base) (2024/9/1)
简介：mk-0773 fa (mk-0773 fa (606101-58-0 free base)) is a selective androgen receptor modulator with an ic50 value of 6.6 nm for ar, which can be used for the prevention and treatment of cancer-related muscle wasting.
MK-0773；化合物 MK-0773PF-05314882；PF-05314882 (2024/9/1)
简介：mk-0773 (pf-05314882) is a selective androgen receptor modulator that binds to ar (ic50: 6.6 nm) for the study of diseases caused by endocrine abnormalities.
NAD+；烟酰胺腺嘌呤二核苷酸Cozymase|||β-DPN|||DPN|||β-Nicotinamide Adenine Dinucleotide|||β-NAD；烟酰胺腺嘌呤二核苷酸|||Coz (2024/9/1)
简介：nad+ (β-nicotinamide adenine dinucleotide) is a coenzyme that transmits hydrogen ions and is involved in redox reactions in cells. nad+ is involved in glycolysis, the citric acid cycle, fatty acid oxidation, etc. nad+ accepts electrons from other molecules to form nadh, which then acts as a reducing agent to give electrons.
MK-0674；化合物 MK-0674MK-0674 (2024/9/1)
简介：mk-0674 is an orally available, selective and potent cathepsin k inhibitor (ic50: 0.4 nm) that inhibits cat b, cat f, cat l, and cat s. it can be used in metabolism-related diseases.
MK-0608；化合物MK-0608MK-0608 (2024/9/1)
简介：mk-0608 is an orally bioavailable hcv replication inhibitor in vitro(ec50 = 0.3 μm and ec90=1.3 μm in the subgenomic-replicon assay).
Quiflapon；喹夫拉朋MK-591；喹夫拉朋|||MK-591 (2024/9/1)
简介：quiflapon (mk-591) causes cell apoptosis. quiflapon is a selective and specific 5-lipoxygenase-activating protein (flap) inhibitor (ic50: 1.6 nm in a flap binding assay) and is also an effective and orally active leukotriene biosynthesis (lt) inhibitor (ic50: 3.1 and 6.1 nm in intact human and elicited rat pmnls, respectively).
MK-0493；化合物 T16086MK-0493 (2024/9/1)
简介：mk-0493 is an effective and selective agonist of the melanocortin receptor 4 (mc4r). it also demonstrated significant reductions in energy intake.
MK-0429化合物 T16085L-000845704 (2024/9/1)
简介：mk-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (ic50: 80 nm).
MK-0343化合物 T16084MRK-409 (2024/9/1)
简介：mk0343 is an orally bioavailable gabaa receptor subtype-selective partial agonist and is a non-sedating anxiolytic.
Mizagliflozin；化合物MizagliflozinGSK-1614235 free base|||KGA-3235 free base|||DSP-3235 free base；GSK-16 (2024/9/1)
简介：mizagliflozin (gsk-1614235 free base) is a sodium-glucose transporter inhibitor( ki of 27 nm for human sglt1). mizagliflozin displays 303-fold selectivity over sglt2. mizagliflozin is used as an antidiabetic drug that can modify postprandial blood glucose excursion. mizagliflozin also exhibits potential in the amelioration of chronic constipation.
Mivotilate；化合物 T16082YH439；YH439 (2024/9/1)
简介：mivotilate, a potent, non-toxic aryl hydrocarbon receptor (ahr) activator, functions as a hepatoprotective agent.
MIV-150；化合物 T16081PC 815；PC 815 (2024/9/1)
简介：miv-150 is a nonnucleoside inhibitor of reverse transcriptase (nnrt). miv-150 also blocking hiv-1 and hiv-2 infections (ec50<1 nm against hiv-1/hiv-2mn).
ADH-1 trifluoroacetate；化合物Exherin trifluoroacetateExherin trifluoroacetate；Exherin trifluoroacetate (2024/9/1)
简介：adh-1 trifluoroacetate (exherin trifluoroacetate) is a cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. adh-1 selectively and competitively binds to and blocks n-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis.
Mirodenafil；米罗那非SK3530；米罗那非|||SK3530 (2024/9/1)
简介：mirodenafil is a pde-5 inhibitor developed for the treatment of erectile dysfunction.
Mirk-IN-1化合物 T16078Dyrk1B/A-IN-1 (2024/9/1)
简介：mirk-in-1 is an effective inhibitor of dyrk1b(mirk kianse) and dyrk1a (ic50: 68±48 nm and 22±8 nm respectively).
Mioflazine；米氟嗪Mioflazine (2024/9/1)
简介：mioflazine suppresses nucleoside uptake. mioflazine is an orally active nucleoside transport inhibitor. it has the potential for sleep disorders treatment.
(Rac)-Idroxioleic acid；2-羟基乳清酸2-Hydroxyoleic acid|||2-OHOA|||Minerval；2-Hydroxyoleic acid|||2-OHOA|| (2024/9/1)
简介：(rac)-idroxioleic acid (2-hydroxyoleic acid) is a fatty acid amide hydrolase inhibitor with anti-tumor effect. it binds to the plasma membrane and alters lipid organization.
Micronomicin；小诺霉素Gentamicin C2b|||Antibiotic XK-62-2|||Sagamicin；小诺霉素|||Gentamicin C2b|||Antibiotic (2024/9/1)
简介：micronomicin (gentamicin c2b) is an antibiotic exhibiting antibacterial and bactericidal capacity.
MI-538；化合物MI-538MI-538 (2024/9/1)
简介：mi-538 is an interaction between menin and mll fusion proteins inhibitor(ic50 of 21 nm).
MGB-BP-3；化合物 MGB-BP-3MGB-BP-3 (2024/9/1)
简介：mgb-bp-3 is a synthetic antibiotic with bactericidal activity that inhibits bacterial dna replication and can be used to study recurrent c. difficile infections.
MF63；化合物 T16070MF63 (2024/9/1)
简介：mf63 is a selective mpges-1 inhibitor (ic50: 0.9 nm and 1.3 nm for pig mpges-1 and human mpges-1 enzyme, respectively).
Hydrastinine hydrochloride北美黄连碱分碱盐酸盐北美黄连碱分碱盐酸盐|||北美黄连碱分碱 (2024/9/1)
简介：hydrastinine hydrochloride is a semisynthetic alkaloid from the hydrolysis of the alkaloid hydrastine, used as a haemostatic drug.
MF498化合物 T16069MF498|||MF-498 (2024/9/1)
简介：mf498 is a novel and selective e prostanoid receptor 4 (ep4 receptor) antagonist, displayed a strong binding affinity for the ep4 receptor (ki: 0.7 nm).
MF-438；化合物MF-438MF-438 (2024/9/1)
简介：mf-438 is an effective and orally bioavailable stearoyl-coa desaturase 1 (scd1) inhibitor (ec50: 2.3 nm for rscd1).
MSN交谈
