9月
MMP13-IN-3；化合物MMP13-IN-3MMP13-IN-3 (2024/9/1)
简介：mmp13-in-3 is >1000 selective over other mmps. mmp13-in-3 is an effective, selective, and orally active mmp-13 inhibitor (ic50=1 nm) for the potential treatment of osteoarthritis.
MMG-11；化合物 T16123MMG-11 (2024/9/1)
简介：mmg-11 inhibits both tlr2/1 and tlr2/6 signaling (ic50s: 1.7 μm for pam3csk4-induced htlr2/1 and 5.7 μm for pam2csk4-induced htlr2/6 responses). mmg-11 is an effective and selective human tlr2 antagonist with low cytotoxicity.
MMAF sodium；化合物 T16122Monomethylauristatin F sodium；Monomethylauristatin F sodium (2024/9/1)
简介：mmaf sodium is widely used as a cytotoxic component of antibody-drug conjugates (adcs) such as vorsetuzumab mafodotin and sgn-cd19a. mmaf sodium is an effective tubulin polymerization inhibitor and is used as an antitumor agent.
MMAF Hydrochloride；化合物 T16121Monomethylauristatin F Hydrochloride；Monomethylauristatin F Hydrochlori (2024/9/1)
简介：mmaf hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (adcs) such as vorsetuzumab mafodotin and sgn-cd19a. mmaf hydrochloride is an effective tubulin polymerization inhibitor and is used as an antitumor compound.
MLT-748；化合物 T16120MLT-748 (2024/9/1)
简介：mlt-748 is an effective, selective, and allosteric malt1 inhibitor. it binds malt1 in the allosteric trp580 pocket (ic50: 5 nm).
Neostigmine methyl sulfate；甲硫酸新斯的明Normastigmin|||Hodostin|||Syntostigmin；Normastigmin|||甲基硫酸新斯的明|||甲 (2024/9/1)
简介：neostigmine methyl sulfate (syntostigmin) is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myasthenia gravis.
MLT-747；化合物 T16119MLT-747 (2024/9/1)
简介：mlt-747 is an effective and allosteric inhibitor of malt1. it binds malt1 in the allosteric trp580 pocket (ic50: 14 nm).
MLS0315771；化合物MLS0315771MLS0315771 (2024/9/1)
简介：mls0315771 is an effective and biologically active competitive phosphomannose isomerase (mpi) inhibitor (ic50: ~1 μm and a ki: 1.4 μm).
Pevonedistat hydrochloride化合物 T16117MLN4924 hydrochloride (2024/9/1)
简介：pevonedistat hydrochloride is an effective and selective inhibitor of nedd8-activating enzyme (ic50: 4.7 nm).
MLN-4760；化合物MLN-4760MLN-4760 (2024/9/1)
简介：mln-4760 is an angiotensin-converting (ace2) inhibitor(human ace2;ic50=0.44 nm). it also has excellent selectivity (>5000-fold) versus related enzymes including human testicular ace (ic50, >100 μm) and bovine carboxypeptidase a (cpda; ic50, 27 μm).
MLi-2；化合物MLi-2MLi-2 (2024/9/1)
简介：mli-2 is a structurally novel, highly potent, and selective lrrk2 kinase inhibitor with central nervous system activity. mli-2 exhibits exceptional potency in a purified lrrk2 kinase assay in vitro (ic50 = 0.76 nm), a cellular assay monitoring dephosphorylation of lrrk2 pser935 lrrk2 (ic50 = 1.4 nm), and a radioligand competition binding assay (ic50 = 3.4 nm).
Pavinetant；化合物 PavinetantMLE-4901|||AZD4901|||AZD2624；MLE-4901|||AZD4901|||AZD2624 (2024/9/1)
简介：pavinetant (mle-4901) is an orally available neurokinin-3 receptor (nk3r) antagonist used to improve menopausal symptoms.
ML753286；化合物 T16113ML753286 (2024/9/1)
简介：ml753286 has high permeability and low to medium clearance in rodent and human liver s9 fractions. ml753286 is an orally active and selective inhibitor of bcrp (ic50: 0.6 μm). it is also stable in plasma across species.
ML67-33化合物 T16112ML-67-33|||ML6733|||ML67 33 (2024/9/1)
简介：ml67-33 rapidly and reversibly affects k2p2.1 (trek-1) (ec50s: 36.3 μm and 9.7 μm in cell-free and hek293 cells, respectively). ml67-33 is a selective activator of temperature- and mechano-sensitive k2p channels.
ML418；化合物ML418ML418 (2024/9/1)
简介：ml418 is a potent, selective and cns penetrating kir7.1 potassium channel blocker (ic50 = 310 nm), and also potently inhibits kir6.2/sur1.
Isotretinoin；异维A酸13-cis-Retinoic acid；13-cis-Retinoic acid|||异维A酸 (2024/9/1)
简介：isotretinoin (13-cis-retinoic acid) binds to and activates nuclear retinoic acid receptors (rars); activated rars serve as transcription factors that promote cell differentiation and apoptosis. isotretinoin is a naturally-occurring retinoic acid with potential antineoplastic activity. this agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.
ML402；化合物ML402ZINC3671497|||N-[2-(4-chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide；ZINC3671497 (2024/9/1)
简介：ml402 (zinc3671497) is an activator of trek-1 and trek-2 with ec50s of 13.7 μm and 5.9 μm.
ML230；化合物 T16107CID44640177|||SID 88095709；CID44640177|||SID 88095709 (2024/9/1)
简介：ml230 is a selective atp-binding cassette (abc) transporter abcg2 inhibitor. it 36-fold selective for abcg2 over abcb1 (ec50s: 0.13 μm and 4.65 μm, respectively).
ML224；化合物ML224NCGC00242364|||ANTAG3；NCGC00242364|||ANTAG3 (2024/9/1)
简介：ml224 (ncgc00242364) is a tshr antagonist for the treatment of graves´ orbital disease and graves´ hyperthyroidism.
ML132；化合物 T16105NCGC 00185682；NCGC 00185682 (2024/9/1)
简介：ml132 is an effective and selective inhibitor of caspase 1 (ic50: 0.316 nm).
ML-9；ML-9盐酸盐ML-9 (2024/9/1)
简介：ml-9 suppresses mlck, pka, and pkc activity with ki values of 4, 32, and 54 μm, respectively. ml-9 is a selective and effective inhibitor of akt kinase, inhibits myosin light-chain kinase (mlck), and stromal interaction molecule 1 (stim1) activity. ml-9 causes autophagy by stimulating autophagosome formation and inhibiting their degradation.
上海受限密闭空间高空吊绳作业 (2024/9/1)
简介：高空
ML-9 Free Base；化合物 T16103ML-9 Free Base (2024/9/1)
简介：ml-9 (free base) suppresses mlck, pka, and pkc activity (ki: 4, 32, and 54 μm, respectively). ml-9 (free base) is a selective and effective inhibitor of akt kinase, inhibits myosin light-chain kinase (mlck), and stromal interaction molecule 1 (stim1) activity. ml-9 (free base) causes autophagy by stimulating autophagosome formation and inhibiting their degradation.
ML-792；化合物ML792ML-792 (2024/9/1)
简介：ml-792 is a specific small ubiquitin-like modifier (sumo)-activating enzyme (sae) inhibitor. compared with nae/nedd8 and uae/ubiquitin (ic50s of 32 μm and >100 μm, respectively), ml-792 is an effective and selective inhibitor of sae/sumo1 and sae/sumo2 in enzymatic assays (ic50s of 3 and 11 nm, respectively).
ML-290；化合物ML-290ML-290 (2024/9/1)
简介：ml-290 is an effective relaxin/insulin-like family peptide receptor (rxfp1) agonist and activator of anti-fibrotic genes. it shows an ec50 of 94 nm.
Balamapimod；化合物 T16100MKI 833；MKI 833 (2024/9/1)
简介：balamapimod is a reversible inhibitor of ras/raf/mek. it also has a potential anti-tumor activity.
Metaxalone；美他沙酮Skelaxin|||Methaxalonum|||Zorane|||NSC170959|||AHR438；Skelaxin|||Methaxalonum|||美他沙酮| (2024/9/1)
简介：metaxalone (methaxalonum) (marketed by king pharmaceuticals under the brand name skelaxin ) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions.
MK8722；化合物MK8722MK8722 (2024/9/1)
简介：mk8722 is an effective and systemic activator of pan-ampk.
Islatravir；化合物IslatravirMK-8591；MK-8591 (2024/9/1)
简介：islatravir (mk-8591) is an effective anti-hiv-1 agent. it acts as a nucleoside reverse transcriptase inhibitor (ec50s: 0.068 nm, 3.1 nm, and 0.15 nm for hiv-1 (wt), hiv-1 (m184v), hiv-1 (mdr), respectively).
MK-8318；化合物 T16097MK-8318 (2024/9/1)
简介：mk-8318 is an effective and selective antagonist of the crth2 receptor (ki: 5.0 nm).
MSN交谈
