9月
MS4078；化合物MS4078MS4078 (2024/9/1)
简介：ms4078 is an inhibitor and aplastic lymphoma kinase (alk) protac (degrader) based on cereblon ligand, with a kd of 19 nm for binding affinity to alk.
Betamethasone 17-benzoate；苯甲酸倍他米松Betamethasone 17-benzoate (2024/9/1)
简介：betamethasone 17-benzoate is a representative steroid. it also can be used in the treatment of recurrent aphothous ulcers (rau).
Ms-PEG7-Ms；化合物 T16151Ms-PEG7-Ms (2024/9/1)
简介：ms-peg7-ms is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Ms-PEG5-t-butyl ester；化合物 T16150Ms-PEG4-t-butyl ester；Ms-PEG4-t-butyl ester (2024/9/1)
简介：ms-peg5-t-butyl ester is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Irbesartan；厄贝沙坦SR-47436|||BMS-186295；厄贝沙坦|||SR-47436|||BMS-186295 (2024/9/1)
简介：irbesartan (sr-47436) is an angiotensin 2 receptor blocker. the mechanism of action of irbesartan is as an angiotensin 2 receptor antagonist.
Ms-PEG4-Ms；化合物 T161491,11-Bis(methanesulfonyloxy)-3,6,9-trioxandecane；1,11-Bis(methanesulfonyloxy)-3 (2024/9/1)
简介：ms-peg4-ms is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Ms-PEG2-C2-Boc；化合物 T16147Ms-PEG2-C2-Boc (2024/9/1)
简介：ms-peg2-c2-boc is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Ms-PEG12-m；化合物 T16146Ms-PEG12-m (2024/9/1)
简介：ms-peg12-m is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
MS-444化合物 T16145BE-34776 (2024/9/1)
简介：ms-444 suppresses the activity of purified smooth muscle myosin light chain kinase (mlck) (ic50: 10 μm).
MRX-2843；化合物MRX-2843UNC2371；UNC2371 (2024/9/1)
简介：mrx-2843 (unc2371) is a potent and orally active inhibitor of mertk and flt3(ic50s of 1.3 nm and 0.64 nm, respectively).
MRTX-1257；化合物MRTX-1257MRTX-1257 (2024/9/1)
简介：mrtx-1257 is a selective, irreversible, and covalent inhibitor of kras g12c. it has an ic50 of 900 pm for kras dependent erk phosphorylation in h358 cells. mrtx1257 demonstrated 31% bioavailability in the mouse, with free fraction exposures well above the cellular potency in a pk/pd experiment, 77% target engagement.
MRT199665；化合物 T16142MRT199665 (2024/9/1)
简介：mrt199665 is an effective and atp-competitive, selective mark/sik/ampk inhibitor (ic50s of 2/2/3/2 nm, 10/10 nm, and 110/12/43 nm for mark1/mark2/mark3/mark14, ampkα1/ampkα2, and sik1/sik2/sik3, respectively). mrt199665 suppresses the phosphorylation of sik substrate crtc3 at s370. mrt199665 induces apoptosis in mef2c-activated human acute myeloid leukemia (aml) cells.
MRT00033659；化合物 T16141MRT00033659 (2024/9/1)
简介：mrt00033659 is an effective broad-spectrum kinase inhibitor of ck1 (ic50=0.9 μm for ck1δ) and chk1 (ic50=0.23 μm). mrt00033659 is a pyrazolo-pyridine analogue. it also induces p53 pathway activation and e2f-1 destabilization.
MRS 1754；化合物MRS 1754MRS 1754 (2024/9/1)
简介：mrs 1754 is a selective antagonist radioligand for the a2b adenosine receptor. it has a very low affinity for a1 and a3 receptors of both humans and rats.
MRS2698；化合物 T16139MRS2698 (2024/9/1)
简介：mrs2698 is an effective and highly selective agonist of the p2y2 receptor (ec50: 8 nm). mrs2698 also is >300-fold p2y2-selective versus the p2y4 and p2y6 receptors.
MRS1186；化合物 T16138MRS1186 (2024/9/1)
简介：mrs1186 is an effective and selective antagonist of the human adenosine a3 receptor (ki: 7.66 nm).
MRS1177；化合物 T16137MRS1177 (2024/9/1)
简介：mrs1177 is an effective and selective antagonist of the human adenosine a3 receptor (ha3ar) (ki: 0.3 nm).
MRS-1706；化合物MRS-1706MRS-1706 (2024/9/1)
简介：mrs-1706 has ki values of 1.39, 112, 157, and 230 nm for human a2b, a2a, a1, and a3 receptors respectively. mrs-1706 is an effective and selective adenosine a2b receptor inverse agonist.
MRS 1523；化合物 T16135MRS 1523 (2024/9/1)
简介：mrs 1523 can exert an antihyperalgesic effect through n-type ca channel block and action potential inhibition in isolated rat dorsal root ganglion (drg) neurons. mrs 1523 is an effective and selective adenosine a3 receptor antagonist ki: 18.9 nm and 113 nm for human and rat a3 receptors, respectively). in rat this corresponds to selectivities of 140- and 18-fold vs a1 and a2a receptors, respectively.
MRS-1191；化合物 T16134MRS-1191 (2024/9/1)
简介：mrs-1191 is an effective and selective a3 adenosine receptor antagonist (kb: 92 nm, a ki: 31.4 nm for human a3 receptor and an ic50: 120 nm for cho cells).
MRK-560；化合物MRK-560MRK-560 (2024/9/1)
简介：mrk-560 is an effective and brain-penetrant inhibitor of γ-secretase.
MRE3008F20；化合物 MRE3008F20MRE3008F20 (2024/9/1)
简介：mre3008f20 is a species-selective and potent adenosine a3 receptor (aa3r) antagonist that inhibits cl-ib-meca-induced camp production and can be used in glaucoma and asthma studies.cas 번호13483-88-88-9
MPT0E028；化合物 T16131MPT0E028 (2024/9/1)
简介：mpt0e028 is an orally active and selective inhibitor of hdac (ic50s of 53.0 nm, 106.2 nm, 29.5 nm for hdac1, hdac2, and hdac6, respectively). mpt0e028 has good anticancer activity. mpt0e028 decreases the viability of b-cell lymphomas by inducing apoptosis and possesses potent direct akt targeting ability and reduces akt phosphorylation in b-cell lymphoma.
Mps1-IN-3；化合物Mps1-IN-3Mps1-IN-3 (2024/9/1)
简介：mps1-in-3 is an effective and selective inhibitor of mps1 kinase (ic50: 50 nm).
Hydralazine hydrochloride；盐酸肼屈嗪Hydralazine HCl|||Apresoline；Hydralazine HCl|||Apresoline|||盐酸肼屈嗪 (2024/9/1)
简介：hydralazine hydrochloride (apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. this agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume, a
MPI_5a；化合物MPI_5aMPI_5a (2024/9/1)
简介：mpi_5a is an effective and selective inhibitor of hdac6 (ic50=36 nm). mpi_5a weakly inhibits other hdac isoforms and it also inhibits acyl-tubulin accumulation in cells (ic50: 210 nm).
MP-A08；化合物MP-A08MP-A08 (2024/9/1)
简介：mp-a08 is a highly selective atp competitive inhibitor of sphingosine kinase (sphk1) that targets both sphk1 and sphk2 (ki: 6.9 ± 0.8 μm and 27 ± 3 μm, respectively).
Moricizine；莫雷西嗪Moracizine；Moracizine|||莫雷西嗪 (2024/9/1)
简介：moricizine is an antiarrhythmia agent which is used primarily for ventricular rhythm disturbances.
Monepantel；化合物 MonepantelAAD1566|||PPL-1；AAD1566|||PPL-1 (2024/9/1)
简介：monepantel (aad1566) is an organic anthelmintic and nicotinic acetylcholine receptor antagonist from roundworms and esophagostomies that is widely used for de-worming in agriculture and livestock.
MMV390048；化合物MMV390048MMV390048 (2024/9/1)
简介：mmv390048 is an antimalarial agent and is a representative of a new chemical class of plasmodium pi4k inhibitor (kdapp=0.3 μm). mmv390048 binds to the atp binding site of plasmodium pi4k and does not bind to other p. falciparum and human kinases apart from human pip4k2c, thus alleviating potential kinase-mediated safety concerns.
MSN交谈
