9月
Bromo-PEG1-acid；化合物 T14783Bromo-PEG1-acid (2024/9/1)
简介：bromo-peg1-acid is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Brilaroxazine；化合物BrilaroxazineRP5063；RP5063 (2024/9/1)
简介：brilaroxazine (rp5063) is a potent multimodal dopamine/5-ht modulator. brilaroxazine is a partial agonist of dopamine d2, d3, and d4 receptors, 5-ht1a (ki =1.5 nm) and 5-ht2a (ki = 2.5 nm), and has antagonist activity 5-ht2b, and 5-ht7 receptors with kis of 0.19 nm and 2.7 nm, respectively. brilaroxazine can be used for research about cognitive impairments in neuropsychiatric and neurological diseases.
Brilacidin；化合物 T14781PMX 30063；PMX 30063 (2024/9/1)
简介：brilacidin is a nonpeptidic anti-infective in a new class of defensin mimetics used for the research of eye infections.
BRD9185；化合物 T14780BRD9185 (2024/9/1)
简介：brd9185 is an inhibitor of dihydroorotate dehydrogenase (dhodh) with an ec50 of 16 nm against multidrug-resistant blood-stage parasites in vitro.
Ondansetron hydrochloride dihydrate；盐酸昂丹司琼SN 307|||NSC 665799|||GR 38032|||Ondansetron hydrochloride (2024/9/1)
简介：ondansetron hydrochloride dihydrate (gr 38032) is a competitive serotonin type 3 receptor antagonist. it is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
BRD7389；化合物BRD7389BRD7389 (2024/9/1)
简介：brd7389 is an inhibitor of rsk family kinase with ic50s of 1.5 μm, 2.4 μm, and 1.2 μm for rsk1, rsk2, and rsk3, respectively.
BRD6989；化合物BRD6989BRD6989 (2024/9/1)
简介：brd6989 is an analog of the natural product cortistatin a (dca). which inhibits cdk8 and upregulates il-10. brd6989 inhibits the kinase activity of recombinant cdk8 or cdk19 complexes. brd6989 selectively binds a complex of cdk8 with an ic50 of ~200 nm.
BRD5529；化合物 T14777BRD5529 (2024/9/1)
简介：brd5529 is a selective inhibitor of card9-e3 ubiquitin ligase trim62 protein-protein interaction (ic50: 8.6 μm). brd5529 directly and selectively binds card9, disrupts trim62 recruitment, inhibits trim62-mediated ubiquitinylation, and activation of card9.
BRD4 Inhibitor-10；化合物BRD4 Inhibitor-10BRD4 Inhibitor-10 (2024/9/1)
简介：brd4 inhibitor-10 is an inhibitor of brd4-bd1 (ic50: 8 nm).
Bragsin2；化合物Bragsin26-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one|||Bragsin 2；6-methoxy-5-nitro (2024/9/1)
简介：bragsin2 (6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one) is a hydration-resistant cell penetrant, selective and non-competitive inhibitor of afr guanine nucleotide exchange factor brag2 that inhibits arf gtpase activation, with an ic50 of 3 μm. bragsin2 binds at the interface between the pleckstrin homology domain of brag2 and the lipid bilayer, leading brag2 unable to activate lipidated arf gtpase.
Bragsin1；化合物 T14774Bragsin1 (2024/9/1)
简介：bragsin1 is a potent and selective and noncompetitive arfgef brag2 inhibitor, inhibits arf gtpase activation(ic50 : 3 μm),and with anti-cancer activity.
Br-PEG4-OH；化合物 T14773Br-PEG4-OH (2024/9/1)
简介：br-peg4-oh is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Br-PEG4-CH2-Boc；化合物 T14772Br-PEG4-CH2-Boc (2024/9/1)
简介：br-peg4-ch2-boc, a peg- and alkyl/ether-based protac linker, serves as a valuable component for the synthesis of protacs[1].
Br-PEG4-C2-Boc；化合物 T14771Br-PEG4-C2-Boc (2024/9/1)
简介：br-peg4-c2-boc is a cleavable 4-unit peg adc linker employed for the synthesis of antibody-drug conjugates (adcs)[1].
Br-PEG3-OH；化合物 T14770Br-PEG3-OH (2024/9/1)
简介：br-peg3-oh is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Pramipexole dihydrochloride；盐酸普拉克索Pramipexole dihydrochloride (2024/9/1)
简介：pramipexole dihydrochloride could be used to treat parkinson disease.
Br-PEG3-CH2COOH；化合物 T14769BrPEG3CH2COOH|||Br PEG3 CH2COOH|||Br-PEG-3-CH2COOH|||Br-PEG3-CH2COOH；BrPEG (2024/9/1)
简介：br-peg3-ch2cooh is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Br-PEG3-C2-Boc；化合物 T14768Br-PEG3-C2-Boc (2024/9/1)
简介：br-peg3-c2-boc is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
BP 897 hydrochloride；化合物BP 897 hydrochlorideBP 897 hydrochloride (2024/9/1)
简介：bp 897 is a potent and selective agonist of dopamine d3 receptor and it is a weak dopamine d2 receptor antagonist, with kis of 0.92 nm and 61 nm for d3 and d2 receptors. which shows low affinities at d1 and d4 receptors (kis, 3 and 0.3 μm, respectively).
BPH-715；化合物BPH-715BPH-715 (2024/9/1)
简介：bph-715 inhibits the liver-stage growth of p. falciparum with an ic50 of 10 μm for p. falciparum exoerythrocytic forms in hepg2 cells.
BOS-172722；化合物BOS-172722BOS-172722 (2024/9/1)
简介：bos-172722 is an inhibitor of monopolar spindle 1 (mps1) checkpoint(ic50 of 2 nm).
BoNT-IN-1；化合物 T14763BoNT-IN-1 (2024/9/1)
简介：bont-in-1 is a potent botulinum neurotoxin a light chain (bonta lc) inhibitor(ic50 : 0.9 um).
Boc-PEG4-sulfonic acid；化合物 T14762Boc-PEG4-sulfonic acid (2024/9/1)
简介：boc-peg4-sulfonic acid is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Boc-PEG2-sulfonic acid；化合物 T14760Boc-PEG2-sulfonic acid (2024/9/1)
简介：boc-peg2-sulfonic acid is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Pramipexole；普拉克索SND 919；SND 919|||普拉克索 (2024/9/1)
简介：pramipexole (snd 919) is a selective dopamine receptor agonist used in the therapy of parkinson disease. pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not been implicated in cases of clinically apparent acute liver injury.
Boc-NH-PEG9-azide；化合物 T14759Boc-NH-PEG9-azide (2024/9/1)
简介：boc-nh-peg9-azide is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Boc-NH-PEG8-propargyl；化合物 T14758Boc-NH-PEG8-propargyl (2024/9/1)
简介：boc-nh-peg8-propargyl is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Boc-NH-PEG7-propargyl；化合物 T14757Boc-NH-PEG7-propargyl (2024/9/1)
简介：boc-nh-peg7-propargyl is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Boc-NH-PEG7-NH2；化合物Boc-NH-PEG7-NH2Boc-NH-PEG7-NH2 (2024/9/1)
简介：boc-nh-peg7-nh2 is a peg-based protac linker.
Boc-NH-PEG7-azide；化合物 T14755Boc-NH-PEG7-azide (2024/9/1)
简介：boc-nh-peg7-azide is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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