9月
Fexofenadine hydrochloride；盐酸非索非那定Terfenidine carboxylate hydrochloride|||MDL-16455 hydrochloride||| (2024/9/1)
简介：fexofenadine hydrochloride (terfenidine carboxylate hydrochloride) is a second generation antihistamine that is used for the treatment of allergic rhinitis, angioedema and chronic urticaria.
BnO-PEG4-OH；化合物 T14699BnO-PEG4-OH (2024/9/1)
简介：bno-peg4-oh is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
BnO-PEG4-Boc；化合物 T14698BnO-PEG4-Boc (2024/9/1)
简介：bno-peg4-boc is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
BnO-PEG1-CH2COOH；化合物 T14697BnO-PEG1-CH2COOH (2024/9/1)
简介：bno-peg1-ch2cooh is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
BnO-PEG1-CH2CO2tBu；化合物 T14696BnO-PEG1-CH2CO2tBu (2024/9/1)
简介：bno-peg1-ch2co2tbu is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
BNC375；化合物 T14695BNC375 (2024/9/1)
简介：bnc375 is a α7 nachrs type i positive allosteric modulator (ec50: 1.9 μm).
BNC105；化合物BNC105BNC105 (2024/9/1)
简介：bnc105 is a tubulin polymerization inhibitor. it has potent antiproliferative and tumor vascular disrupting properties.
BN201；化合物 T14693BN201 (2024/9/1)
简介：bn201, a chemical compound, actively crosses the blood-brain barrier and activates the igf-1 pathway, which is associated with stress response and neuron survival. it facilitates neuronal differentiation and the maturation of precursor cells into oligodendrocytes with an ec50 of 6.3 μm, in addition to promoting the myelination of new axons with an ec50 of 16.6 μm in vitro. bn201 exhibits potent neuroprotective effects[1].
BMX-IN-1；化合物BMX-IN-1BMX kinase inhibitor；BMX kinase inhibitor (2024/9/1)
简介：bmx-in-1 (bmx kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome x (bmx, ic50 = 8 nm) and the related bruton’s tyrosine kinase (btk, ic50 = 10.4 nm), but bmx-in-1 is more than 47-656 fold less potent against blk, jak3, egfr, itk, or tec activity.
BMT-090605；化合物 T14691BMT-090605 (2024/9/1)
简介：bmt-090605 is a potent, selective aak1 inhibitor, with an ic50 of 0.6 nm. bmt-090605 inhibits bmp-2-inducible protein kinase (bike) and cyclin g-associated kinase (gak) with ic50s of 45 and 60 nm, respectively[1]. bmt-090605 shows antinociceptive activity.
BMS 433796；化合物BMS 433796BMS-289948|||BMS-299897；BMS-289948|||BMS-299897 (2024/9/1)
简介：bms 433796 is a γ-secretase inhibitor that demonstrates aβ-lowering activity within a transgenic mouse model of alzheimer´s disease.
Levocetirizine；左西替利嗪Levocetirizine HCl；Levocetirizine HCl|||左西替利嗪 (2024/9/1)
简介：levocetirizine is a histamine-1 receptor antagonist. the mechanism of action of levocetirizine is as a histamine h1 receptor antagonist.
BMS493；化合物 BMS493BMS-493；BMS-493 (2024/9/1)
简介：bms493 is an inverse agonist of the pan-retinoic acid receptor (rar) that inhibits retinoic acid-induced differentiation, enhances the interaction of nuclear co-inhibitors with rars, attenuates ra signaling, potentiates tpp-induced toxicity, and inhibits the increase in phospholipase a2 activity.
BMS CCR2 22；化合物BMS CCR2 22BMS CCR2 22 (2024/9/1)
简介：bms ccr2 22 is a potent and selective antagonist of ccr2 with calcium flux ic50 of 18 nm, chemotaxis ic50 of 1 nm, and binding ic50 of 5.1 nm.
Deucravacitinib；化合物BMS-986165BMS-986165；BMS-986165 (2024/9/1)
简介：deucravacitinib (bms-986165) inhibits il-12/23 and type i ifn pathways[1][2]. bms-986165 is a highly selective, orally bioavailable allosteric tyk2 inhibitor for the treatment of autoimmune diseases. which selectively binds to tyk2 pseudokinase (jh2) domain (ic50=1.0 nm) and blocks receptor-mediated tyk2 activation by stabilizing the regulatory jh2 domain.
BMS-986163；化合物 T14686BMS-986163 (2024/9/1)
简介：bms-986163 is a negative allosteric modulator of glun2b and the prodrug bms-986163 rapidly converts to its active parent molecule bms-986169 (ki=4 nm, ic50=24 nm).
BMS-986158；化合物BMS-986158BMS-986158 (2024/9/1)
简介：bms-986158 is a highly effective bet inhibitor, demonstrating ic50 values of 6.6 nm in nci-h211 small cell lung cancer (sclc) cells and 5 nm in mda-mb231 triple negative breast cancer (tnbc) cells.
BMS-986120；化合物 T14684BMS-986120 (2024/9/1)
简介：bms-986120 is a first-in-class oral and reversible protease-activated receptor 4 (par4) antagonist. with ic50s of 9.5 nm and 2.1 nm in human and monkey blood, respectively. bms-986120 has potent and selective antiplatelet effects[1][2].
BMS-983970；化合物 T14683BMS-983970 (2024/9/1)
简介：bms-983970 is an oral inhibitor of pan-notch, and for the treatment of multiplecancers.
BMS-962212；化合物 T14682BMS-962212 (2024/9/1)
简介：bms-962212, a direct, reversible, and selective factor xia (fxia) inhibitor, demonstrates fast pharmacodynamic (pd) response onset and rapid elimination with a well-tolerated profile. it dependently increases activated partial thromboplastin time and decreases fxi clotting activity exposure [1].
BMS-935177；化合物BMS-935177BMS-935177 (2024/9/1)
简介：bms-935177 is a reversible btk inhibitor with ic50 value of 3 nm.
BMS-906024；化合物 BMS-906024Osugacestat|||AL-101|||BM-0018；Osugacestat|||AL-101|||BM-0018 (2024/9/1)
简介：bms-906024 (osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule notch inhibitor.bms-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.bms-906024 prevents the activation of all four notch receptors, and is active against notch1, -2, -3 and -4 receptors. bms-906024 prevents the activation of all four notch receptors, with ic50s of 1.6, 0.7, 3.4 and 2.9 nm for notch1, -2, -3 and -4 receptors, respectively.
Lornoxicam；氯诺昔康Ro 13-9297|||Chlortenoxicam|||TS110；Ro 13-9297|||Chlortenoxicam|||TS110|||氯诺昔康 (2024/9/1)
简介：lornoxicam (chlortenoxicam) (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (nsaid) of the oxicam class with analgesic, anti-inflammatory, and antipyretic properties. lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the particularly pronounced efficacy of the drug. lornoxicam is approved for use in japan.
BMS-819881；化合物 T14678BMS-819881 (2024/9/1)
简介：bms-819881 is a melaninconcentrating hormone receptor 1 (mchr1) antagonist, which binds rat mchr1 with a ki of 7 nm and it also is selective and potent for cyp3a4 activity with an ec50 of 13 μm.
BMS-690514；化合物BMS-690514BMS-690514 (2024/9/1)
简介：bms-690514 is a potent and orally active inhibitor of egfr and vegfr. it has ic50s of 5, 20 and 60 nm for egfr, her 2 and her 4, respectively.
BMS-688521化合物 BMS-688521BMS688521|||BMS 688521 (2024/9/1)
简介：bms-688521 bms-688521 is an orally active and potent inhibitor of lfa-1/icam interaction, a small molecule antagonist of leukocyte function-associated antigen-1 (lfa-1), with potential anti-inflammatory activity.
BMS-564929；化合物 T14675BMS-564929 (2024/9/1)
简介：bms-564929 is an agonist of androgen receptor (ar, ki of 2.11±0.16 nm).
BMS-509744；化合物 T14674BMS-509744 (2024/9/1)
简介：bms-509744 is an inhibitor of atp competitive itk (ic50: 19 nm).
BMS 299897；化合物BMS 299897BMS 299897 (2024/9/1)
简介：bms 299897 is a sulfonamide γ-secretase inhibitor. it has an ic50 of 7 nm for aβ production inhibition in hek293 cells stably overexpressing amyloid precursor protein (app).
BMS-248360；化合物 T14672BMS-248360 (2024/9/1)
简介：bms-248360 is a potent and orally active dual antagonist of both angiotensin ii receptor (at1) and endothelin a (eta) receptor. with kis of 10 nm and 1.9 nm for hat1 and heta receptor, respectively. bms-248360 shows hypertensive effects[1].
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