9月
CL2A-SN-38 DCA 1279680-68-0(free base)；化合物CL2A-SN-38 DCACL2A-SN-38 DCA 1279680-68-0(free base) (2024/9/1)
简介：cl2a-sn-38 is a drug-linker conjugate composed of a potent a dna topoisomerase i inhibitor sn-38 and a linker cl2a to make antibody drug conjugate (adc).. cl2a-sn-38 is composed of a potent a dna topoisomerase i inhibitor sn-38 and a linker cl2a to make antibody drug conjugate (adc). cl2a-sn-38 provides significant and specific antitumor effects against a range of human solid tumor types. cl2a is a noncleavable complicated peg8- and triazole-containing pabc-peptide-mc linker. cl2a is cleavable t
CL2A-SN-38；化合物CL2A-SN-38CL2A|||CL2A SN 38|||bystander effect|||SN-38|||antitumor|||CL2A-SN-38|||Inhi (2024/9/1)
简介：cl2a-sn-38 is a drug-linker conjugate consisting of sn-38, a potent dna topoisomerase i inhibitor, and linker cl2a, for the manufacture of antibody drug conjugates (adcs). cl2a-sn-38 provides significant and specific antitumor effects against a range of human solid tumor types. cl2a is a nonclaevable complicated peg8- and triazole-containing pabc-peptide-mc linker. cl2a is cleavable through ph sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulf
CL2 Linker；化合物 T17730CL2 Linker (2024/9/1)
简介：cl2 linker is a cleavableadc linker. cl2-sn-38 and cl2a-sn-38 are equivalent in drug substitution (~6), cell binding (kd ~1.2 nm), cytotoxicity (ic50 ~2.2 nm), and serum stability in vitro (t1/2 ~20 hours)[1][2].
Afatinib Dimaleate；双马来酸盐阿法替尼BIBW2992|||Afatinib|||BIBW 2992MA2|||Afatinib (BIBW2992) Dimaleate；马来酸阿法 (2024/9/1)
简介：afatinib dimaleate (bibw 2992ma2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (rtk) epidermal growth factor receptor (erbb; egfr) family, with antineoplastic activity.
Cl-C6-PEG4-C3-COOH；化合物 T17729Cl-C6-PEG4-C3-COOH (2024/9/1)
简介：cl-c6-peg4-c3-cooh, a protac linker, is a suitable component for synthesizing chloroalkane-containing protacs (haloprotacs).
PROTAC CDK9 degrader-2；化合物 T17728PROTAC CDK9 degrader-2 (2024/9/1)
简介：protac cdk9 degrader-2 (compounds 11c) is a potent and selective cdk9 degrader based on protac, with an ic50 of 17 μm in mcf-7 cell lines. natural product wogonin binds ubiquitin e3 ligase cereblon (crbn) via a linker to form protac[1].
CCK2R Ligand-Linker Conjugates 1；化合物 T17727CCK2R Ligand-Linker Conjugates 1 (2024/9/1)
简介：cck2r ligand-linker conjugate 1 is a hydrophilic peptide linker that conjugates to the cytotoxic antimicrotubule agents desacetyl vinblastine hydrazide (davbh) and tubulysin b hydrazide (tubbh) as ligand-linker conjugates[1].
Cbz-Phe-(Alloc)Lys-PAB-PNP；化合物 T17726CbzPhe(Alloc)LysPABPNP|||Cbz Phe (Alloc)Lys PAB PNP|||Cbz-Phe-( (2024/9/1)
简介：cbz-phe-(alloc)lys-pab-pnp serves as a cleavable linker in the design of antibody-drug conjugates (adc).
Cbz-NH-PEG8-CH2COOH；化合物 T17725Cbz-NH-PEG8-CH2COOH (2024/9/1)
简介：cbz-nh-peg8-ch2cooh is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Cbz-NH-PEG5-CH2COOH；化合物Cbz-NH-PEG5-CH2COOHCbz-NH-PEG5-CH2COOH (2024/9/1)
简介：cbz-nh-peg5-ch2cooh is a peg-based protac linker that can be used in protac synthesis.
Cbz-NH-PEG36-C2-acid；化合物 T17723Cbz-NH-PEG36-C2-acid (2024/9/1)
简介：cbz-nh-peg36-c2-acid is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Cbz-NH-PEG3-CH2COOH；苯甲氧羰酰基二聚乙二醇羧乙基Inhibitor|||PROTAC Linkers|||inhibit|||CbzNHPEG3CH2COOH|||Cbz-NH-P (2024/9/1)
简介：cbz-nh-peg3-ch2cooh is a peg-based protac linker that can be used in protac synthesis.
Cbz-NH-PEG24-C2-acid；化合物 T17721Cbz-NH-PEG24-C2-acid (2024/9/1)
简介：cbz-nh-peg24-c2-acid is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Cbz-NH-PEG2-CH2COOH8-苄氧羰基氨基-3,6-二氧杂辛酸8-苄氧羰基氨基-3,6-二氧杂辛酸 (2024/9/1)
简介：cbz-nh-peg2-ch2cooh is a peg-based protac linker that can be used in protac synthesis.
MDK83190；化合物Apoptosis Activator 2Apoptosis Activator 2；Apoptosis Activator 2 (2024/9/1)
简介：mdk83190 (apoptosis activator 2) is a potent apoptosis activator, induceing caspase-3 activation, parp cleavage, and dna fragmentation .
Cbz-NH-PEG12-C2-acid；化合物Cbz-NH-PEG12-C2-acidCbz-NH-PEG12-C2-acid (2024/9/1)
简介：cbz-nh-peg12-c2-acid is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Cbz-NH-PEG10-CH2COOH；化合物 T17718Cbz-NH-PEG10-CH2COOH (2024/9/1)
简介：cbz-nh-peg10-ch2cooh is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Cbz-NH-PEG1-CH2COOH苄氧羰基聚乙二醇乙酸苄氧羰基聚乙二醇乙酸 (2024/9/1)
简介：cbz-nh-peg1-ch2cooh is a peg-based protac linker that can be used in protac synthesis.
Cbz-NH-PEG1-CH2CH2COOH苄氧羰基聚乙二醇丙酸苄氧羰基聚乙二醇丙酸 (2024/9/1)
简介：cbz-nh-peg1-ch2ch2cooh is a peg-based protac linker that can be used in protac synthesis.
Cbz-N-PEG15-amine；化合物 T17715Cbz-N-PEG15-amine (2024/9/1)
简介：cbz-n-peg15-amine is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Cbz-N-PEG10-acid；化合物 T17714Cbz-N-PEG10-acid (2024/9/1)
简介：cbz-n-peg10-acid is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Cbz-N-amido-PEG20-acid；化合物 T17713Cbz-N-amido-PEG20-acid (2024/9/1)
简介：cbz-n-amido-peg20-acid is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Cbz-aminooxy-PEG8-Boc；化合物 T17712Cbz-aminooxy-PEG8-Boc (2024/9/1)
简介：cbz-aminooxy-peg8-boc is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Cbz-aminooxy-PEG8-acid；化合物 T17711Cbz-aminooxy-PEG8-acid (2024/9/1)
简介：cbz-aminooxy-peg8-acid is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Carboxyrhodamine 110-PEG4-DBCO；化合物 T17710Carboxyrhodamine 110-PEG4-DBCO (2024/9/1)
简介：carboxyrhodamine 110-peg4-dbco is a peg-based protac linker utilized in protac synthesis[1].
Ro 48-8071 fumarate；化合物Ro 48-8071 fumarateRo 48-8071 fumarate (2024/9/1)
简介：ro 48-8071 fumarate is an inhibitor of osc(oxidosqualene cyclase; ic50=6.5 nm) that has low-density lipoprotein (ldl) cholesterol lowering activity.
Carboxymethyl-PEG-Carboxymethyl (MW 5000)；化合物 T17709Carboxymethyl-PEG-Carboxymethyl (MW 5000) (2024/9/1)
简介：carboxymethyl-peg-carboxymethyl (mw 5000) is a polyethylene glycol (peg)-based linker, specifically designed for the synthesis of protacs [1].
Carboxyfluorescein-PEG12-NHS；化合物 T17708Carboxyfluorescein-PEG12-NHS (2024/9/1)
简介：carboxyfluorescein-peg12-nhs is a polyethylene glycol (peg)-based proteolysis targeting chimera (protac) linker. it serves as a crucial component in synthesizing protacs, a class of molecules designed for targeted protein degradation[1].
C6-Bis-phosphoramidic acid diethyl ester；化合物 T17707C6-Bis-phosphoramidic acid diethyl ester (2024/9/1)
简介：c6-bis-phosphoramidic acid diethyl ester is an alkyl chain-derived protac linker suitable for protac synthesis[1].
BzNH-BS；化合物 T17706BzNH-BS (2024/9/1)
简介：bznh-bs is a chemical compound comprising two distinct ligands: methyl-bestatin (mebs) for ciap1 and benzoyl-amide. the ligands are interconnected through linkers. mebs functions as a ligand for ciap1, a ubiquitin ligase involved in cellular inhibition of apoptosis processes [1].
MSN交谈
