9月
DNP-PEG6-acid；化合物 T17840DNP-PEG6-acid (2024/9/1)
简介：dnp-peg6-acid is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
英国雷尼绍M3三坐标测针 (2024/9/1)
简介：红宝石是一种ji为坚硬的材料，因此测球的磨损甚微。它还具有较低密度，使测尖的质量min，从而避免了因设备运行或振动而引起测头的误触发。
Everolimus；依维莫司RAD001|||SDZ-RAD；依维莫司|||RAD001|||SDZ-RAD (2024/9/1)
简介：everolimus (sdz-rad) is a derivative of rapamycin, an mtor1 inhibitor with selective and oral activity. everolimus exhibits immunosuppressive and antitumor activity, inhibiting tumor cell proliferation, inducing apoptosis and autophagy.
DNP-PEG4-DBCO；化合物 T17839DNP-PEG4-DBCO (2024/9/1)
简介：dnp-peg4-dbco is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
DNP-PEG12-NHS ester；化合物 T17838DNP-PEG12-NHS ester (2024/9/1)
简介：dnp-peg12-nhs ester is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
DNP-PEG12-acid；化合物 T17837DNP-PEG12-acid (2024/9/1)
简介：dnp-peg12-acid is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
DMAC-SPP；化合物 T17836DMAC-SPP (2024/9/1)
简介：dmac-spp is a cleavable linker vital in adc synthesis. dmac-spp joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. the cleavable nature ensures controlled drug release, optimizing adc effectiveness.
DMAC-PDB；化合物 T17835DMAC-PDB (2024/9/1)
简介：dmac-pdb is a cleavable linker vital in adc synthesis. dmac-pdb joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. the cleavable nature ensures controlled drug release, optimizing adc effectiveness.
DM4-SPDP；化合物 T17834DM4-SPDP (2024/9/1)
简介：dm4-spdp, a drug-linker conjugate, integrates the antitubulin agent dm4 with the linker smcc, facilitating the creation of antibody drug conjugates[1]. additionally, spdp serves as a short-chain crosslinker enabling amine-to-sulfhydryl conjugation, leveraging nhs-ester and pyridyldithiol groups to establish cleavable (reducible) disulfide bonds with cysteine sulfhydryls[2][3].
DM4-SMCC；化合物 T17833DM4-SMCC (2024/9/1)
简介：dm4-smcc, a non-cleavable drug-linker conjugate for antibody-drug conjugates (adc), leverages the antitumor efficacy of dm4 (an antitubulin agent) through attachment with the smcc linker, exhibiting antitumor activity[1].
DM1-PEG4-DBCO；化合物 T17832DM1-PEG4-DBCO (2024/9/1)
简介：dm1-(peg)4-dbco is a drug-linker conjugate that combines the potent microtubulin inhibitor mertansine (dm1) with the dbco-peg4-ahx linker for the development of antibody-drug conjugates (adcs). this conjugation aims to mitigate the systemic toxicity associated with maytansine while improving tumor-specific delivery, leveraging dm1’s capabilities as an antibody-conjugatable maytansinoid.
Dioxoisoindolin-O-PEG-OMe (MW 2000)；化合物 T17831(1,3-dioxoisoindolin-2-yl)-O-PEG-OMe (MW 2000)；(1,3-di (2024/9/1)
简介：dioxoisoindolin-o-peg-ome (mw 2000) is a polyethylene glycol (peg) based protac linker, which finds application in the synthesis of protacs[1].
英国雷尼绍M3三坐标测针 (2024/9/1)
简介：红宝石是一种ji为坚硬的材料，因此测球的磨损甚微。它还具有较低密度，使测尖的质量min，从而避免了因设备运行或振动而引起测头的误触发。
Dioxoisoindolin-O-PEG-OH (MW 2000)；化合物 T17830(1,3-dioxoisoindolin-2-yl)-O-PEG-OH (MW 2000)；(1,3-diox (2024/9/1)
简介：dioxoisoindolin-o-peg-oh (mw 2000) is a polyethylene glycol (peg)-based linker utilized for the synthesis of protacs (proteolysis targeting chimeras)[1].
LXR-623；化合物LXR623LXR623|||WAY 252623；LXR623|||WAY 252623 (2024/9/1)
简介：lxr-623 (way 252623) is an orally bioavailable and highly specifical synthetic modulator of lxr.
Canagliflozin hemihydrate；卡格列净半水合物JNJ28431754|||TA 7284|||TA7284|||TA-7284|||JNJ 28431754|||JNJ-2843 (2024/9/1)
简介：canagliflozin hemihydrate (ta 7284) is a drug of the gliflozin class or subtype 2 sodium-glucose transport inhibitors used for the treatment of type 2 diabetes. sglt2 is responsible for at least 90% of renal glucose reabsorption (sglt1 being responsible for the remaining 10%). blocking this transporter causes up to 119 grams of blood glucose per day to be eliminated through the urine, corresponding to 476 kilocalories.
Diketone-PEG4-PFP ester；化合物 T17829Diketone-PEG4-PFP ester (2024/9/1)
简介：diketone-peg4-pfp ester is a polyethylene glycol (peg) derivative employed as a protac linker in the fabrication of proteolysis-targeting chimeras (protacs)[1].
Diketone-PEG4-Biotin；化合物 T17828Diketone-PEG4-Biotin (2024/9/1)
简介：diketone-peg4-biotin is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Diketone-PEG12-DBCO；化合物 T17827Diketone-PEG12-DBCO (2024/9/1)
简介：diketone-peg12-dbco is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Diketone-PEG12-Biotin；化合物 T17826Diketone-PEG12-Biotin (2024/9/1)
简介：diketone-peg12-biotin is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Diketone-PEG11-PFP ester；化合物 T17825Diketone-PEG11-PFP ester (2024/9/1)
简介：diketone-peg11-pfp ester serves as a peg-based protac linker for protac synthesis[1].
Diketone-PEG11-Diketone；化合物 T17824Diketone-PEG11-Diketone (2024/9/1)
简介：diketone-peg11-diketone is a polyethylene glycol (peg)-based linker utilized for the synthesis of proteolysis-targeting chimeras (protacs)[1].
Diethylene glycol bis(p-toluenesulfonate)二乙二醇双对甲苯磺酸酯二乙二醇双对甲苯磺酸酯|||Bis-Tos-PEG2|||Diethylene glycol d (2024/9/1)
简介：diethylene glycol bis(p-toluenesulfonate) (bis-tos-peg2) is a peg-based protac linker that can be used in protac synthesis.
Diazo Biotin-PEG3-DBCO；化合物 T17822Diazo Biotin-PEG3-DBCO (2024/9/1)
简介：diazo biotin-peg3-dbco is a cleavable three-unit polyethylene glycol (peg) linker employed in the synthesis of antibody-drug conjugates (adcs)[1].
Dde Biotin-PEG4-TAMRA-PEG4 Alkyne；化合物 T17820Dde Biotin-PEG4-TAMRA-PEG4 Alkyne (2024/9/1)
简介：dde biotin-peg4-tamra-peg4 alkyne, a peg-based protac linker, facilitates protac synthesis[1].
Canagliflozin；卡格列净JNJ 24831754ZAE|||JNJ 28431754AAA|||TA 7284|||JNJ 28431754；卡格列净|||JNJ 24831754ZAE| (2024/9/1)
简介：canagliflozin (jnj 28431754aaa), a sodium-glucose transporter 2( sglt2) and p-glycoprotein inhibitor, is used in type 2 diabetes.
Thalidomide-O-amido-C8-NH2；化合物 T17819E3 Ligase Ligand-Linker Conjugates 20|||Cereblon Ligand-Linker (2024/9/1)
简介：thalidomide-o-amido-c8-nh2 (cereblon ligand-linker conjugates 2) is a synthesized e3 ligase ligand-linker conjugate comprising a thalidomide-based cereblon ligand and a linker. this compound is useful in the synthesis of protacs, as per reference [1].
Thalidomide-O-amido-C4-NH2；化合物 T17818E3 Ligase Ligand-Linker Conjugates 19|||Cereblon Ligand-Linker (2024/9/1)
简介：thalidomide-o-amido-c4-nh2 (cereblon ligand-linker conjugates 6) is a synthesized ligand-linker conjugate that combines a thalidomide-based cereblon ligand with a linker. it functions as an e3 ligase ligand-linker conjugate and finds applications in the synthesis of protacs[1].
英国雷尼绍M2三坐标测针 (2024/9/1)
简介：红宝石是一种ji为坚硬的材料，因此测球的磨损甚微。它还具有较低密度，使测尖的质量min，从而避免了因设备运行或振动而引起测头的误触发。
DBCO-(PEG)3-VC-PAB-MMAE；化合物 T17817DBCO (PEG)3 VC PAB MMAE|||DBCO-(PEG)3-VC-PAB-MMAE|||DBCO(PEG)3VCPA (2024/9/1)
简介：dbco-(peg)3-vc-pab-mmae is a chemical compound where monomethyl auristatin e (mmae), a potent tubulin inhibitor acting as a toxin payload in antibody-drug conjugates, is conjugated to a dbco-(peg)3-vc-pab linker.
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