提供者：上海雅吉生物科技有限公司 发布时间：2026/10/9 8:53:13 阅读次数：70次 进入该公司店铺
文章标题：Epigenetic downregulation of MAPKAPK2 exacerbates oxidative stress－induced damage in vitiligo melanocyte cell line model
作者列表：Yishan Wang, Xiaoyong Zheng
影响因子：3
期刊：Frontiers in Medicine
发表时间：2026－4－20
DOI:10.3389/fmed.2026.1698091
文献主题：Abstract
Background ｏbjective
Vitiligo is an acquired depigmentation disorder caused by melanocyte dysfunction or loss. Oxidative stress is widely considered a key driver to its pathogenesis. Mitogen－activated protein kinase－activated protein kinase 2 (MAPKAPK2) is implicated in oxidative stress responses, although its role in vitiligo remains uncertain. This study intended to investigate whether epigenetic downregulation of MAPKAPK2 aggravates oxidative stress－induced damage in vitiligo melanocytes.
Methods
Human melanocyte lines (PIG1 PIG3V) were used to model normal vitiligo conditions. The effects of oxidative stress, DNA demethylation (5－aza－DC), MAPKAPK2 overexpression were assessed using qRT－PCR, Western blot, ELISA, comet assay, TUNEL, CCK－8. Pharmacological inhibition of MK2 was employed to evaluate the functional requirement of MAPKAPK2 kinase activity, key antioxidant pathways, including Nrf2 signaling, were investigated.
① 凡本网注明"来源：阿仪网"的所有作品，版权均属于阿仪网，未经本网授权不得转载、摘编或利 用其它方式使用。已获本网授 权的作品，应在授权范围内使用，并注明"来源：阿仪网"。违者本网将追究相关法律责任。
② 本信息由注册会员：上海雅吉生物科技有限公司发布并且负责版权等法律责任。
版权声明