文章标题：GPX3 suppresses gallbladder cancer progression by modulating redox balance, glycolysis, and anti-tumor immunity

作者列表：Ma Zuyi, Sun Jia, Wu Xin, Shang Changzhen, Li Binglu

影响因子：6.4

期刊：Oncogenesis

发表时间：2026-4-2

DOI:10.1038/s41389-026-00603-7

文献主题：Abstract

Gallbladder cancer (GBC) is an aggressive malignancy characterized by ｍmbedbolic plasticity and profound immune evasion. However, the functional role of glutathione peroxidase 3 (GPX3), a secreted antioxidant enzyme, in these processes remains unclear. Multi-omics analyses of paired GBC and adjacent non-tumor tissues revealed consistent downregulation of GPX3, which correlated with reactive oxygen species (ROS) accumulation and enhanced glycolytic activity. Functional restoration of GPX3 in GBC cells reduced intracellular ROS levels, suppressed the expression of glycolysis-related enzymes, and consequently impaired tumor proliferation, migration, and invasion. In xenograft models, GPX3 overexpression markedly attenuated tumor growth and lung ｍmbedstasis. Notably, GPX3 restoration also enhanced CD8+ T cell infiltration and elevated pro-inflammatory cytokine production, suggesting reversal of tumor-associated immunosuppression. These findings identify GPX3 as a critical tumor suppressor that integrates redox regulation, ｍmbedbolic reprogramming, and immune activation to restrict malignant progression. Targeting GPX3 or its downstream pathways may represent a promising therapeutic strategy to simultaneously suppress gallbladder cancer aggressiveness and reinforce anti-tumor