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Losmapimod

CAS No. : 585543-15-3

MCE 国际站：Losmapimod

产品活性：Losmapimod (GSK-AHAB) 是一种有效的，具有口服活性的选择性 p38 MAPK 抑制剂，抑制 p38α 和 p38β 的 pK_i 值分别为 8.1 和 7.6。

研究领域：MAPK/ERK Pathway | Autophagy

作用靶点：p38 MAPK | Autophagy

In Vivo: In the spontaneously hypertensive stroke-prone rat (SHR-SP), chronic treatment with GSK-AHAB significantly ａnd dose-dependently improves survival, endothelial-dependent ａnd -independent vascular relaxation, ａnd indices of renal function, ａnd it attenuates dyslipidemia, hypertension, cardiac remodeling, plasma renin activity (PRA), aldosterone, ａnd interleukin-1β (IL-1β).

相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Autophagy Compound Library | Drug Repurposing Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Pyroptosis Compound Library | Orally Active Compound Library | Neurodegenerative Disease-related Compound Library | Angiogenesis Related Compound Library | SB 203580 | SB 202190 | BI-3406 | Doramapimod | Hesperetin | Ralimetinib dimesylate | PD 169316 | Neflamapimod | TAK⁻⁷15 | SB 239063 | PF-3644022 | Dehydrocorydaline | PH⁻⁷97804 | Pexmetinib | VX⁻⁷02 | Talmapimod | Bakuchiol | MAPK13-IN-1 | C16-PAF | BMS-582949 hydrochloride | Dihydrocaffeic acid | Dilmapimod | Pamapimod | Semapimod tetrahydrochloride | Skatole | ITX5061 | Licochalcone E | MW-150

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