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Dapivirine hydrochloride

MCE 国际站：Dapivirine hydrochloride

品牌：MedChemExpress (MCE)

货号：HY-14266A

CAS：244768-47-6

存储条件：请按照分析证书中建议的条件储存产品。

运输条件：美国大陆的室温；其他地区可能有所不同。

产品活性：Dapivirine hydrochloride是一种非核苷反转录酶抑制剂，具有抗肿瘤活性。Dapivirine hydrochloride能减弱胶质母细胞瘤细胞的增殖，并诱导其凋亡。Dapivirine hydrochloride调节自噬，激活Akt、Bad和SAPK/JNK信号通路。Dapivirine hydrochloride在体外和体内均显示出抑制胶质瘤细胞生长的效果。Dapivirine hydrochloride还是一种应用于HIV-1性传播预防的局部微生物剂的有前景的药物候选者。

生物活性：盐酸达匹韦林是一种具有抗肿瘤活性的非核苷逆转录酶抑制剂。盐酸达匹韦林可抑制胶质母细胞瘤细胞的增殖并诱导细胞凋亡。盐酸达匹韦林可调节自噬并激活 Akt、Bad 和 SAPK/JNK 信号通路。盐酸达匹韦林在体外和体内均显示出对胶质瘤细胞生长的抑制作用。盐酸达匹韦林也是预防 HIV-1 性传播的有希望的局部微生物制剂候选药物[1]。

热销产品：Naftifine (hydrochloride) | Tiopronin | Rifamycin (sodium) | Boc-D-alaninol | LY3177833 | Aftin-4 | Rose Bengal (sodium) | EGA | NGP555 | Cjoc42

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参考文献：

[1]. Weiwen Liu, et al. Antitumor Activity and Mechanism of a Reverse Transcriptase Inhibitor, Dapivirine, in Glioblastoma. J Cancer. 2018 Jan 1;9(1):117-128.
[2]. Antitumor Activity and Mechanism of a Reverse Transcriptase Inhibitor, Dapivirine, in Glioblastoma
[3]. Bríd Devlin, et al. Development of dapivirine vaginal ring for HIV prevention. Antiviral Res. 2013 Dec;100 Suppl:S3-8.
[4]. Yven Van Herrewege, et al. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC⁻⁷81 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob Agents Chemother. 2004 Jan;48(1):337-9.
[5]. Michael E Halwes, et al. Pharmacokinetic modeling of a gel-delivered dapivirine microbicide in humans. Eur J Pharm Sci. 2016 Oct 10;93:410-8.