MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Imidazole ketone erastin

CAS No. : 1801530-11-9

MCE 国际站：Imidazole ketone erastin

产品活性：Imidazole ketone erastin 是一种有效的，选择性的，代谢稳定的胱氨酸-谷氨酸逆转运蛋白，system x_c^- 抑制剂和 ferroptosis 活化剂。Imidazole ketone erastin 具有抗肿瘤活性。

研究领域：Apoptosis

作用靶点：Ferroptosis

In Vitro: Imidazole ketone erastin (IKE) (0.1 nM-100 µM; 24 h) potently reduces diffuse large B cell lymphoma (DLBCL) cell number by lipid peroxidation ａnd ferroptosis.
?IKE (1-250 nM; 24 h) depletes reduced glutathione (GSH) in a dose-dependent manner with an IC₅₀ of 34 nM in SUDHL6 cells.
?IKE (125-500 nM) increases lipid ROS in a dose-dependent manner in SUDHL-6 cells.
?IKE (500 nM; 5-360 min) increases the system x_c^? component SLC7A11, prostaglandin-endoperoxide synthase 2 (PTGS2), ａnd ChaC glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) expression in SUDHL-6 cells.
?IKE (500 nM ａnd 1 µM) changes the relative abundance of 62 lipid species including lysophosphatidylcholines (LPC), phosphatidylcholines (PC), phosphatidylethanolamines (PE), ａnd triglycerides (TAGs) in SUDHL6 cells.
?IKE (500 nM) activates de novo lipid biosynthesis pathways, phospholipid remodeling pathways, ａnd arachidonic acid oxidation pathways in SUDHL6 cells.

In Vivo: IKE (23-40 mg/kg; i.p. once daily for 13 d) inhibits tumor growth in mice.
?IKE (50 mg/kg; a single i.p) depletes GSH significantly starting from 4 h, ａnd increases in the relative abundance of free fatty acids, phospholipids, ａnd diacylglycerols (DAG) in mice.
?IKE (50 mg/kg) exhibits half-life (1.82, 1.31, ａnd 0.96 h) ａnd C_max (19515, 11384, ａnd 5203 ng/mL) following different administration (i.p., i.v., ａnd p.o. respectively) in mice.

相关产品：Ferrostatin-1 | Erastin | Cisplatin | Cycloheximide | RSL3 | Acetylcysteine | ML385 | Sorafenib | Necrostatin-1 | SP600125 | Rosiglitazone | Liproxstatin-1 | Curcumin | Simvastatin | Hemin | TBHQ | Lapatinib | L-Glutathione reduced | Roxadustat | Trolox | Lovastatin | Sulfasalazine | NADPH tetrasodium salt | U⁻⁷3122 | Pifithrin-α hydrobromide | Pioglitazone | iFSP1 | Atorvastatin hemicalcium salt | FIN56 | Bardoxolone methyl

Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds

品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
• 提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。