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Aldometanib

CAS No. : 2904601-67-6

MCE 国际站：Aldometanib

产品活性：Aldometanib (LXY-05-029) 是一种醛缩酶抑制剂。Aldometanib 可以激活溶酶体腺苷-磷酸活化蛋白激酶 AMPK 并降低血糖。Aldometanib 可用于代谢稳态的研究。

研究领域：Epigenetics | PI3K/Akt/mTOR

作用靶点：AMPK

In Vitro: Aldometanib (0-1000 nM; 2 h) activates AMPK by preventing aldolase from binding to FBP to engender a pseudo-starvation signal.

In Vivo: Aldometanib (oral; 0-10 mpk) reduces blood glucose in lean mice.
?Aldometanib (oral; 2-10 mpk; twice daily; for a week) reduces blood glucose ａnd alleviates fatty liver in obese hyperglycaemic mice.
?Aldometanib alleviates fatty liver ａnd nonalcoholic steatohepatitis.
?Aldometanib (oral; 2mpk; twice-daily; for a month) alleviates liver fibrosis in NASH mice.
?Aldometanib (oral; 0-50 µM; 0-50 days) extends lifespan in C. elegans via the lysosomal pathway.

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