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Onametostat

CAS No. : 2086772-26-9

MCE 国际站：Onametostat

产品活性：Onametostat (JNJ-64619178) 是一种伪不可逆的、口服活性的、选择性蛋白精氨酸甲基转移酶 5 (PRMT5) 抑制剂，IC₅₀ 为 0.14 nM。Onametostat 有潜力用于肺癌的研究。

研究领域：Epigenetics

作用靶点：Histone Methyltransferase

In Vitro: Onametostat binds simultaneously to the S-adenosylmethionine (SAM)- ａnd protein substrate- binding pockets of the PRMT5/MEP50 complex with a pseudo-irreversible mode-of-action. Onametostat shows potent ａnd broad inhibition of cellular growth.

In Vivo: Oral administration of Onametostat results in efficient inhibition of dimethylation of SMD1/3 proteins, components of the splicing machinery ａnd direct substrates of the methylosome, in several non-small cell lung cancer ａnd small cell lung cancer? cancer mouse xenograft models.

相关产品：Covalent Screening Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Epigenetics Compound Library | Histone Modification Research Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Covalent Screening Library | Reprogramming Compound Library | Orally Active Compound Library | Anti-Lung Cancer Compound Library | Anti-Blood Cancer Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | PRMT5-IN-17 | EZM0414 | BIX-01294 | WDR5-IN-5 | CARM1-IN-3 | PRMT5-IN-22 | Gambogenic acid | SGC707 | Dot1L-IN⁻⁷ | MS1943 | PRMT5-IN-21 | NSD3-IN-3 | DCLX069 | MAK683 | DS-437 | EPZ020411 | NSD-IN-2 | WDR5-IN-4 TFA | Amodiaquine dihydrochloride | Furamidine | SMYD3-IN-2 | UNC0642 | Chaetocin | UNC0646 | UNC0224 | EBI-2511 | BVT948 | MM-401 | CMP-5

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