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Bisindolylmaleimide I hydrochloride

CAS No. : 176504-36-2

MCE 国际站：Bisindolylmaleimide I hydrochloride

产品活性：Bisindolylmaleimide I (GF109203X) hydrochloride 是一种具有细胞渗透性和可逆性的 PKC 抑制剂 (对 PKCα, PKCβI, PKCβII, ａnd PKCγ 的 IC₅₀ 分别为 20 nM、17 nM、16 nM 和 20 nM)。Bisindolylmaleimide I hydrochloride 也是一种 GSK-3 抑制剂。

研究领域：Epigenetics | TGF-beta/Smad | PI3K/Akt/mTOR | Stem Cell/Wnt

作用靶点：PKC | GSK-3

In Vitro: Bisindolylmaleimide I hydrochloride (5 µM) inhibits α-thrombin-induced P47 phosphorylation.
Bisindolylmaleimide I hydrochloride (0-1 µM) inhibits DNA synthesis in quiescent swiss 3T3 cells.
Bisindolylmaleimide I hydrochloride (5 µM) reduces GSK-3 activity to 25.1±4.3% in adipocytes lysates.
Bisindolylmaleimide I hydrochloride (10 µM, 24 h) inhibits exosome ａnd microvesicle (EMV) release from PC3 cells.
Bisindolylmaleimide I hydrochloride (10 µM, 24 h) enhances cytotoxicity of 5-fluorouracil (HY-90006).

In Vivo: Bisindolylmaleimide I hydrochloride (0.02 mg/kg, i.p.) reduced the inceased NLRP3, P-PKC, ａnd PKC levels in mechanical ventilation (MV) group.
Bisindolylmaleimide I hydrochloride (0-20 mg/kg, i.p.) reduces the mean frequency of Quinpirole-induced vomiting in shrews.

相关产品：Bioactive Compound Library Plus | Epigenetics Compound Library | Kinase Inhibitor Library | PI3K/Akt/mTOR Compound Library | Stem Cell Signaling Compound Library | TGF-beta/Smad Compound Library | Wnt/Hedgehog/Notch Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Glycolysis Compound Library | Cytoskeleton Compound Library | Exosomes Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Glucose Metabolism Compound Library | Human Metabolite Library | Non-steroidal Anti-Inflammatory Compound Library | Cancer Stem Cells Compound Library | Coagulation ａnd Anti-coagulation Compound Library | Membrane Protein-targeted Compound Library | BRD5648 | SB-218078 | p32 Inhibitor M36 | AR-A014418 | Staurosporine | N-Myristoyl-Lys-Arg-Thr-Leu-Arg | PF-04577806 | GSK-3β inhibitor 3 | Bisindolylmaleimide II | Hypericin | SAR502250 | D-erythro-Sphingosine | GSK 3 Inhibitor IX | K00546 | Mitoxantrone diacetate | R 59-022 hydrochloride | Ingenol Mebutate | GSK-3β inhibitor 10 | DIF-3 | Hu7691 free base | 1-Stearoyl-2-arachidonoyl-sn-glycerol | Procyanidin A1 | Hispidin | Ionomycin | CRT0066854 | Protein kinase inhibitor H⁻⁷ | Spisulosine | 1,2-Dimyristoyl-sn-glycerol | PKC-IN-4

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