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Tibulizumab

CAS No. : 1849636-24-3

MCE 国际站：Tibulizumab

产品活性：Tibulizumab (LY 3090106) 是一种四价双特异性单克隆抗体，靶向 B 细胞激活因子 (BAFF) 和 IL-17A，Kd 值分别为 60 pM 和 14 pM。 Tibulizumab 可用于自身免疫性疾病研究。

研究领域：Apoptosis | Immunology/Inflammation

作用靶点：TNF Receptor | Interleukin Related

In Vitro: Tibulizumab (LY 3090106) binds to mouse BAFF with a K_D of 340 nM ａnd does not bind to mouse IL-17. Tibulizumab binds to cynomolgus BAFF ａnd cynomolgus IL-17 with K_D of 26.8 pM ａnd 19 pM, respectively.
In HT-29 cells, Tibulizumab antagonizes the IL-17-induced secretion of CXCL1 in a concentration-dependent manner (IC₅₀ of 2.00 nM). In T1165 cells, Tibulizumab blocks BAFF-induced proliferation in a concentration-dependent manner (IC₅₀ of 0.064 nM). Tibulizumab simultaneously binds ａnd blocks both BAFF ａnd IL-17.

In Vivo: Tibulizumab (LY 3090106; 660 g/mouse, i.p; 66 g/mouse, s.c) effectively antagonizes the biological effects induced by human BAFF ａnd IL-17 in the mouse.
In cynomolgus monkey, Tibulizumab (i.v, 0.3, 1, 5, or 20 mg/kg; or s.c, 5 mg/kg) suppresses B cell development ａnd survival ａnd remains functionally intact in circulation, with a prolonged half-life.

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