MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Crotedumab

CAS No. : 1452387-69⁻⁷

MCE 国际站：Crotedumab

产品活性：Crotedumab (REGN1193) 是一种人源化的 IgG4 单克隆抗体，可结合并抑制胰高血糖素受体 (GCGR)，K_D 值为 0.1 nM。Crotedumab 可用于糖尿病的研究。

研究领域：GPCR/G Protein

作用靶点：GCGR

In Vitro: Crotedumab binds to GCGR from multiple species (mouse, rat, monkey, ａnd humans) with high affinity (K_D=0.03 nM-0.39 nM).
Crotedumab inhibits Glucagon-induced signaling through GCGR with IC₅₀s of 0.65, 3.2, 0.94 ａnd 1.0 nM in HEK293 cells transfected with GCGR from human, monkey, mouse, ａnd rat, respectively.

In Vivo: Crotedumab (3-30 mg/kg; s.c. once weekly for 4 weeks) reduces blood glucose ａnd body weight ａnd induces reversible hyperglucagonemia ａnd α-cell hyperplasia in DIO C57BL/6 mice.
Crotedumab (10 mg/kg; a single s.c.) markedly decreases blood glucose for 18 days in diabetic ob/ob mice.
REGN1193 (20 mg/kg; a single i.v.) produces a robust reduction in overnight-fasted blood glucose in both the conscious ａnd anesthetized state of diabetic cynomolgus monkeys as well as in blood glucose measured 1 hour after feeding.

相关产品：Dulaglutide | PF-06291874 | Neuropeptide Y, porcine | HAEGTFTSDVS | Glucagon receptor antagonists-5 | Oxyntomodulin TFA | Tirzepatide TFA | Liraglutide | GLP-1R agonist 1 | Exendin-4 acetate | GLP-1(7-37) acetate | V-0219 | Glucagon (1-29), bovine, human, porcine | GPCR modulator-1 | Oxyntomodulin (swine) | VU0453379 | Cotadutide | Elsiglutide | GLP-1 receptor agonist 7 | Avexitide | Glucagon-like peptide 1 (1-37), human TFA | Semaglutide TFA | GLP-1R modulator C5 | Glucagon (19-29), human | Efinopegdutide | [Des-His1,Glu9]-Glucagon amide TFA | Exendin-3/4 (59-86) | FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸

Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides

品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；
• 40,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。