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Inclacumab

CAS No. : 1256258-86-2

MCE 国际站：Inclacumab

产品活性：Inclacumab (Anti-Human selectin P Recombinant Antibody) 是人源化的 IgG4 单克隆抗体选择性的靶向 P-selectin，K_d 值为 9.9 nM。Inclacumab 抑制 P-selectin 糖蛋白配体 1 (PSGL-1) 模拟肽与 P-selectin 结合，IC₅₀ 值为1.9 g/mL。Inclacumab 强烈的抑制细胞黏附。

研究领域：Others

作用靶点：Others

In Vitro: Inclacumab (0.4-40 µg/mL; 5 min) significantly reduces flow adhesion of P-Selectin with Whole Blood (WB) ａnd isolated White Blood Cell (I-WBC) ａnd shows a more stronger effect on isolated white cells.
Inclacumab shows great binding affinity to P-selectin with a K_d value of 9.9 nM.
Inclacumab inhibits PSGL-1 mimetic peptide binding with P-selectin with an IC₅₀ value of 1.9 g/mL.
Inclacumab blocks the adhesion of PSGL-1 expressing cells to an immobilized P-selectin with an IC₅₀ value of 430 ng/mL.
Inclacumab (0-100 µg/mL; 5min) dose-dependently inhibits thrombin receptor-activating peptide (TRAP)-induced platelet-leukocyte aggregates (PLA) levels with an IC₅₀ value of 1.4 µg/mL.

In Vivo: Inclacumab (4 mg/kg; s.c. once) reduces TRAP- ａnd ADP-induced PLA levels in cynomolgus monkeys.
Inclacumab (2-50 mg/kg; i.v.; once a week for 13 weeks) inhibits TRAP induced PLA levels in cynomolgus monkeys.

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