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SZM679

CAS No. :

MCE 国际站：SZM679

产品活性：SZM679 是一种口服有效的选择性 RIPK1 抑制剂，对 RIPK1 和 RIPK3 的 K_d 值分别为 8.6 nM 和 >5000 nM。SZM679 逆转肿瘤坏死因子诱导的全身炎症反应。SZM679 可降低海马和皮质中 Tau 蛋白的过度磷酸化、神经炎症和 RIPK1 磷酸化水平。SZM679 可用于阿尔茨海默病 (AD) 的研究。

研究领域：Apoptosis

作用靶点：RIP kinase

In Vitro: SZM679 (0-10 µM; 24 h; necrotic L929 ａnd HT-29 cells) has an anti-necrosis activity by Inhibiting the RIPK1 pathway with an EC₅₀ value of 2 nM. SZM679 also protects against TNF-α, cycloheximide, ａnd z-VAD-fmk (TCZ)-induced necroptosis. SZM679 protects against necroptosis induced by TZ in a dose dependent manner.
SZM679 (1 µM; 6 h; necrotic HT-29 cells) selectively inhibits the expression of RIPK1 but not RIPK3 or MLKL. SZM679 blocks necrosome formation by inhibiting TSZ-induced phosphorylation of RIPK1.

In Vivo: SZM679 (10-40 mg/kg; i.p.; male C57BL/6 J mice with TNF-induced SIRS models) protects against necroptosis-specific TNF-induced systemic inflammatory response syndrome (SIRS) in vivo.
SZM679 (1 mg/kg; administered intragastrically; once daily for 7 days) improves cognitive function in STZ-induced AD mice.
SZM679 (1 mg/kg; administered intragastrically; once daily for 7 days) rescues brain structure damage with no obvious toxicity ａnd decreases AD biomarkers ａnd decreases the expression levels of inflammatory cytokines ａnd inhibits RIPK1 phosphorylation in the brain tissues of AD mice.

相关产品：RIPA-56 | RIPK1-IN-3 | RIP1 kinase inhibitor 1 | Desmethyl-WEHI-345 analog | RIP2 kinase inhibitor 2 | PROTAC RIPK degrader-6 | TP-030-1 | PK68 | RIPK1-IN-4 | MLKL-IN-4 | NecroIr2 | RIPK1-IN-14 | GSK963 | AV123 | RIP2 Kinase Inhibitor 4 | Necrostatin 2 | RIPK1-IN-11 | ICCB-19 hydrochloride | RIPK3-IN-2 | GSK2983559 active metabolite | OD36 | RIP2 kinase inhibitor 1 | GSK840 | RIPK1-IN-15 | Necroptosis-IN-1 | GSK-872 | RIP1/RIP3/MLKL activator 1 | NecroIr1

热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸

Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides

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