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Geranylgeraniol

CAS No. : 24034⁻⁷3-9

MCE 国际站：Geranylgeraniol

产品活性：Geranylgeraniol 是一种口服有效的维生素 K₂ 亚型，是甲戊酸途径 (mevalonate pathway) 的中间体。Geranylgeraniol 靶向 NF-kB 信号通路，可在动物模型中减轻脂多糖 (LPS) 诱导的小胶质细胞炎症。

研究领域：NF-κB

作用靶点：NF-κB

In Vitro: Geranylgeraniol (0-10 µM; 24 h) dose-dependently suppresses the LPS-induced increase in the mRNA levels of Il-1β, Tnf-α, Il-6, ａnd Cox-2.
Geranylgeraniol (10 µM; 24 h) inhibits the phosphorylation of TAK1, IKKα/β, ａnd NF-κB p65 proteins as well as NF-κB nuclear translocation induced by LPS while maintaining IκBα expression.
Geranylgeraniol, (50 µM; 24 h) eliminates cell damage caused by Simvastatin (HY-17502) (10 M) ａnd Mevalonat (10 mM), ａnd reduces the inflammatory marker ａnd the damage of the mitochondria, maintaining its shape ａnd component.

In Vivo: Geranylgeraniol (725 mg/kg/d; p.o.; 90 d) is not toxicologically significant with a dose below 725 mg/kg/d in rats.
Geranylgeraniol (483 mg/kg/d; p.o.; 10 d) suppresses lipopolysaccharide-induced inflammation via inhibition of nuclear factor-κB activation in rats.

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