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DY-46-2

CAS No. : 1105110-83-5

MCE 国际站：DY-46-2

产品活性：DY-46-2 是一种高效、选择性高的新型非核苷 DNA 甲基转移酶 3A (DNMT3A) 抑制剂，其IC₅₀ 值为 1.3 µM。

研究领域：Epigenetics

作用靶点：DNA Methyltransferase

In Vitro: DY-46-2 (0.1-100 µM, 24, 48 ａnd 72 h) has an inhibitory activity of DNMT3A with an IC₅₀ value of 0.39 µM, which increases linearly with DNA concentration (IDT-01).
DY-46-2 (0.1-100 µM, 24, 48 ａnd 72 h) has inhibitory activity against DNMT1, DNMT3B ａnd G9a with IC₅₀ values of 13.0 µM, 105 µM ａnd ＞500 µM, respectively.
DY-46-2 (0.1-100 µM, 24, 48 ａnd 72 h) has cell viability in cancer cells with IC₅₀ values of 0.7 µM, 0.3 µM, 0.7 µM, 0.5 µM, 2.1 µM, 1.7 µM ａnd 91 µM for THP-1, HCT116, U937, K562, A549, DU145 ａnd PBMC cell, respectively.
DY-46-2 (0.1-100 µM, 24, 48 ａnd 72 h) markedly inhibits the proliferation of cancer cells ａnd shows low cytotoxicity in peripheral blood mononuclear cells (PBMCs).
DY-46-2 (1 µM, 72 h) obviously decreases DNMT3A protein levels, as well as reactive expression of a silenced TSG (p53) in HCT116 cells.

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