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Dipyrithione

CAS No. : 3696-28-4

MCE 国际站：Dipyrithione

产品活性：Dipyrithione 是一种有效的抗菌剂。Dipyrithione 显示出抗真菌活性和抗增殖活性。Dipyrithione 诱导细胞凋亡 (apoptosis) 和周期停滞在 G1 期。 Dipyrithione 在体内显示出抗炎活性。 Dipyrithione 显示出抗肿瘤活性。 Dipyrithione 具有研究皮肤癣菌病的潜力。

研究领域：Apoptosis | Anti-infection

作用靶点：Apoptosis | Bacterial | Fungal

In Vitro: Dipyrithione (20µg/mL) shows antifungal activity with MIC values of 6.03 M for Trichophyton rubrum.
Dipyrithione (72 h) shows cytotoxic activity against 293T cells with an IC₅₀ value of 0.22 M.
Dipyrithione (1-5 M; 8.5 h) inhibits LPS (100 ng/ml)-induced up-regulation of iNOS ａnd COX-2 in RAW264.7 cells in a dose-dependent manner.
Dipyrithione (1 M; 8.5 h) suppresses LPS-induced increase of iNOS but not COX-2 mRNA level, inhibits LPS-increased NO production.
Dipyrithione (3 M; 2, 5 h) decreases phosphorylation of STAT1 induced by LPS ａnd does not influence LPS-induced MAPK ａnd NF-κB activation in RAW 246.7 cells.
Dipyrithione (0-5 µg/mL; 48 h) shows antiproliferative activity for KB, 231, U937 ａnd K562 cells in a dose dependent manner.
Dipyrithione (2.5 µg/ml) induces apoptosis ａnd cycle arrest at G1 phase.

In Vivo: Dipyrithione (0.2 mg/cm²; externally once daily for 10 days) shows great anti-dermatophyte activity effects in guinea pig.
Dipyrithione (1, 2.5, 5 mg/kg; i.p.) shows anti-inflammatory activity in mouse.Dipyrithione (5 mg/kg; i.p.; daily for 10 days) shows anti-tumor acyivity in mouse.

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