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Aspirin lithium

CAS No. : 552-98⁻⁷

MCE 国际站：Aspirin lithium

产品活性：Aspirin (Acetylsalicylic Acid) lithium 是一种口服有效的不可逆的环氧合酶 COX-1 和 COX-2 抑制剂，IC₅₀ 分别为 5 和 210 µg/mL. Aspirin lithium 诱导细胞凋亡 (apoptosis)。Aspirin lithium 可抑制 NF-κB 的活化。Aspirin lithium 还抑制血小板前列腺素合成酶 (prostaglandin synthetase)，可预防冠状动脉和脑血管血栓形成。

研究领域：Immunology/Inflammation | Anti-infection | NF-κB | Autophagy | Apoptosis | MAPK/ERK Pathway

作用靶点：COX | Virus Protease | NF-κB | Autophagy | Apoptosis | Mitophagy | Caspase | p38 MAPK

In Vitro: Aspirin lithium inhibits COX-1 ａnd COX-2 in human articular chondrocytes, with IC₅₀ values of 3.57 µM ａnd 29.3 µM, respectively.
Aspirin lithium acetylates serine-530 of COX-1, thereby blocking thromboxane A synthesis in platelets ａnd reducing platelet aggregation.
Aspirin lithium inhibits COX-2 protein expression through interference with binding of CCAAT/enhancer binding protein beta (C/EBPbeta) to its cognate site on COX-2 promoter/enhancer.
Aspirin lithium inhibits NF-κB-dependent transcription from the lgκ enhancer ａnd the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.
Aspirin lithium induces apoptosis by the activation of caspases, the activation of p38 MAP kinase, release of mitochondrial cytochrome c, ａnd activation of the ceramide pathway.

In Vivo: Aspirin lithium (5-150 mg/kg, PO, once) shows significant antipyretic activity in adult yeast-fevered male rats.

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