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Fadrozole hydrochloride hemihydrate

CAS No. : 176702⁻⁷0-8

MCE 国际站：Fadrozole hydrochloride hemihydrate

产品活性：Fadrozole hydrochloride hemihydrate 是一种口服有效的、选择性非甾体芳香化酶 (aromatase) 抑制剂，其 IC₅₀ 为 6.4 nM。Fadrozole hydrochloride hemihydrate 抑制雌激素和孕酮的产生，其 IC₅₀ 值分别为 0.03 和 120 µM。Fadrozole hydrochloride hemihydrate 可预防自发性肿瘤。Fadrozole hydrochloride hemihydrate 可用于雌激素依赖性疾病和癌症的研究。

研究领域：Others

作用靶点：Aromatase

In Vitro: Synthesis of other cytochrome P-450 dependent steroids can be suppressed to various degrees with higher doses of Fadrozole hydrochloride hemihydrate.

In Vivo: Fadrozole hydrochloride hemihydrate is able to inhibit the aromatase-mediated uterine hypertrophy in immature female rats with an ED₅₀ of 0.03 mg/kg when given orally.
Fadrozole hydrochloride hemihydrate prevents the development of both benign ａnd malignant spontaneus mammary neoplasns in female Sprague-Dawley rats. It also slows the spontaneous development of ptuitary pars distalis adenomas in female rats, ａnd reduces the incidence of spontaneous hepatocellular tumours in male ａnd female rats.
Administration of Fadrozole hydrochloride hemihydrate in male ａnd female mice accompanies with a 70% reduction in parasite burden. This protective effect is associated in male mice with a recovery of the specific cellular immune response.

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