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JQKD82 trihydrochloride

CAS No. :

MCE 国际站：JQKD82 trihydrochloride

产品活性：JQKD82 (JADA82) trihydrochloride 是一种细胞通透性和选择性 KDM5 抑制剂。JQKD82 trihydrochloride 增加 H3K4me3，可用于多发性骨髓瘤的研究。

研究领域：Epigenetics

作用靶点：Histone Demethylase

In Vitro: JQKD82 (0.3 µM; 24 hours) trihydrochloride causes an increase in the global H3K4me3 level of MM.1S cells.
JQKD82 (0.1-10 µM; day 1-day 5) trihydrochloride inhibits the growth of MM.1S cells in a dose- ａnd time-dependent manner. JQKD82 trihydrochloride is potent at eliciting growth suppression in MM.1S cells (IC₅₀=0.42 µM).
JQKD82 (1 µM; 24 hours) trihydrochloride induces G1 cell-cycle arrest by 48 hours in MM.1S ａnd MOLP-8 cells.

In Vivo: JQKD82 (50⁻⁷5 mg/kg; i.p.; twice a day for 3 weeks) trihydrochloride has anti-multiple myeloma activity.
JQKD82 trihydrochloride displays an increase in H3K4me3 levels ａnd results in a dramatic reduction of MYC immuno-staining in vivo.

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