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Norisoboldine

CAS No. : 23599-69-1

MCE 国际站：Norisoboldine

产品活性：Norisoboldine 是一种具有口服活性的天然芳基烃受体 (AhR) 激动剂。Norisoboldine 作为林参中主要的异喹啉类生物碱，可用于类风湿性关节炎和溃疡性结肠炎的研究。

研究领域：GPCR/G Protein

作用靶点：Adenosine Receptor

In Vitro: Norisoboldine (1~30 µM; 0~24 hours; CD4+T cells) activates AhR under hypoxic microenvironment and significantly downregulates mRNA expression of miR-31.
Norisoboldine (30 µM; 0~24 hours; CD4+T cells) inhibits glycolysis in hypoxia.
Norisoboldine (1~30 µM; 0~72 hours; Treg cells) promotes Treg differentiation in hypoxia.
Norisoboldine (10, 30 µM) facilitates the disassociation of HSP90/AhR complexes, the nuclear translocation of AhR, and the formation of AhR/ARNT complexes. Norisoboldine induces generation of Treg cells in hypoxia is independent of miR-31.

In Vivo: Norisoboldine (10~40 mg/kg; p.o.; 20 days) significantly reduces the severity of joint swelling and erythema during the course of the experiment.
Norisoboldine (40 mg/kg; i.g.; 10 days) induces enhancement of CYP1A1 expression and suppresses expressions of Glut1 and HK2 in colons.

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