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Gramine

CAS No. : 87-52-5

MCE 国际站：Gramine

产品活性：Gramine (Donaxine) 是从芦竹中得到的生物碱，为有效的脂联素受体 (adiponectin receptor (AdipoR)) 激动剂，对 AdipoR2 和 AdipoR1 的 IC₅₀ 值分别为 3.2 和 4.2 µM。Gramine 同时为小鼠和人 β2-Adrenergic receptor (β2-AR) 激动剂。Gramine 具有抗肿瘤、抗炎和抗病毒作用。

研究领域：GPCR/G Protein | Neuronal Signaling | Anti-infection

作用靶点：Adiponectin Receptor | Adrenergic Receptor | Reverse Transcriptase

In Vitro: Gramine is an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 µM for AdipoR2 and AdipoR1, respectively. Gramine is a potential β2-AR agonist.
Gramine (20 µM to 1.2 nM) dose-dependently inhibits the growth of AdipoR1/adipoR2-positive cancer cell lines (MDA-MB-231 and MCF⁻⁷ cells), with IC₅₀s of 9.6±0.9 and 0.1±0.1 µM, respectively.

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