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Serotonin hydrochloride

CAS No. : 153-98-0

MCE 国际站：Serotonin hydrochloride

产品活性：Serotonin (5-Hydroxytryptamine) hydrochloride 是 CNS 中的单胺神经递质和内源性 5-HT 受体激动剂。Serotonin hydrochloride 也是儿茶酚 O-甲基转移酶 (COMT) 的抑制剂其 K_i 值为 44 µM。

研究领域：GPCR/G Protein | Neuronal Signaling | Metabolic Enzyme/Protease

作用靶点：5-HT Receptor | COMT | Endogenous Metabolite

In Vitro: Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (K_i= 44 µM). Results show that addition of 100 µM of Serotonin hydrochloride decreases the reaction velocity of COMT.

In Vivo: Serotonin hydrochloride produces robust hypersensitivity compare to saline-treated controls (p<0.001). A significant increase in colonic 5-HT content is observed in IL-13^-/- mice receiving Serotonin hydrochloride compare to IL-13^-/- receiving vehicle following induction of DSS colitis.

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