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SRS16-86

CAS No. : 1793052-96-6

MCE 国际站：SRS16-86

产品活性：SRS16-86 是 ferroptosis 的有效抑制剂。SRS16-86 在体内比 Ferrostatin-1 对代谢和血浆更稳定。SRS16-86 可用于肾缺血再灌注损伤 (IRI) 和脊髓损伤 (SCI) 研究。

研究领域：Apoptosis

作用靶点：Ferroptosis

In Vitro: SRS16-86 (1 µM; 24 hours; in the presence or absence of erastin) inhibits ferroptosis in HT-1080 cells ａnd NIH 3T3 cells.

In Vivo: SRS16-86 (intraperitoneal injection; 2 mg/kg; 15 min before the onset of surgery) protects mice from functional acute renal failure ａnd structural organ damage after ischemia–reperfusion injury (IRI).
SRS16-86 (intraperitoneal injection; 2 mg/kg; 4 weeks) combination therapy with [Nec-1+SfA] is superior in the prevention of renal IRI compared with the double-combination therapy with [Nec-1+SfA]. Addition of 16-86 reduces plasma levels of serum urea ａnd serum creatinine in IRI mice model.
SRS16-86 (intraperitoneal injection; 15 mg/kg; once a day; 7 days) enhances functional recovery after SCI, it decreases the levels of proinflammatory cytokines ａnd the inflammatory adhesion factor in injured spinal cord in rats.

相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | Ferroptosis Compound Library | Erastin | Ferrostatin-1 | Cisplatin | Cycloheximide | RSL3 | Acetylcysteine | Deferoxamine mesylate | SP600125 | Sorafenib | Necrostatin-1 | ML385 | Rosiglitazone | SB 202190 | Roxadustat | Liproxstatin-1 | Hemin | Curcumin | TBHQ | (-)-Epigallocatechin Gallate | Lapatinib | Simvastatin | U⁻⁷3122 | Bardoxolone methyl | Pifithrin-α hydrobromide | Lovastatin | Trolox | L-Glutathione reduced | Eprenetapopt | Pioglitazone

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