MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Dynorphin A (1-10)

CAS No. : 79994-24-4

MCE 国际站：Dynorphin A (1-10)

产品活性：Dynorphin A (1-10) 是一种内源性的阿片样神经肽，与 κ 阿片受体 (κ-opioid receptor) 结合。Dynorphin A (1-10) 也阻断 NMDA 激活的电流，IC₅₀ 为 42.0 μM。

研究领域：GPCR/G Protein | Neuronal Signaling | Membrane Transporter/Ion Channel

作用靶点：Opioid Receptor | iGluR

In Vitro: Dynorphin A (1-10) binds in the transmembrane domain of the κ-receptor. The non-opioid actions of various forms of Dynorphin A (DynA) are examined on N-methyl-D-aspartate (NMDA) receptor channels in isolated rat trigeminal neurons using the whole-cell patch recording technique. All the dynorphins tested blocked NMDA-activated currents. The blocking actions are voltage-independent. The IC₅₀ is 42.0 μM for DynA(1-10). To determine if shorter dynorphins have the similar blocking property, we examined the action of DynA(1-10) at different membrane potentials. DynA(1-10) blocks I_NMDA to a similar extent as the membrane potentials changed from -80 to +60 mV. Thus, despite a 160-fold difference in the apparent affinities, DynA(1-32) ａnd DynA(1-10) both exert voltage-independent actions on NMDA receptors.

相关产品：D-AP5 | Dizocilpine maleate | NMDA | CNQX | DAMGO | NBQX | L-Phenylalanine | Naltrindole hydrochloride | Kynurenic acid | Ibotenic acid | Aticaprant | Ifenprodil tartrate | Quinolinic acid | L-Glutamic acid monosodium salt | Glycine | Sinomenine hydrochloride | JDTic dihydrochloride | Matrine | Loperamide hydrochloride | Ro 25-6981 Maleate | Nalfurafine hydrochloride | D-Cycloserine | DNQX | Transcrocetin | Traxoprodil | [Leu5]-Enkephalin | Nociceptin | ADL-5859 | CX546

品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。