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MS21570

CAS No. : 65373-29⁻⁷

MCE 国际站：MS21570

产品活性：MS21570 是 GPR171 的选择性拮抗剂，其 IC₅₀ 值为 220 nM。

研究领域：Others

作用靶点：Others

In Vivo: MS21570 significantly attenuates this CNO-mediated increase in food intake. Interestingly, MS21570 causes a significant increase in center time compared to vehicle suggesting an effect on the anxiety-like behavior. Intra-BLA administration of MS21570 leads to an increase in open arm time on the elevated plus maze although there is no effect on locomotor activity during this test. Interestingly, when administered before and immediately following fear conditioning, MS21570 significantly attenuates freezing measured 24 hours later. Behavioral differences between systemic and intra-BLA administration of MS21570 could be due to the pharmacokinetic and pharmacodynamic properties of the drug. Further studies are needed to characterize the GPR171 antagonist.

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