MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

GSK-4716

CAS No. : 101574-65-6

MCE 国际站：GSK-4716

产品活性：GSK-4716 是一种选择性 ERRβ/γ 激动剂。

研究领域：Others

作用靶点：Estrogen Receptor/ERR

In Vitro: Treatment of differentiated C2C12 cells with the ERRβ/γ agonist (relative to vehicle) over a 2 to 4 h time period reveals a reproducible and robust increase in the immunoreactivity of the GRα-D isoform. It is observed that MAO-A mRNA expression is significantly increased by treatment with the ERRβ/γ agonist, GSK4716. Furthermore, it is observed that GSK4716 induces the expression of the mRNAs encoding peroxisome proliferator-activated receptor-γcoactivator 1α (PGC-1α) and PGC-1β (key regulator of many metabolic genes) identified as direct coactivators for the ERR family. GSK4716 induces the expression of PGC-1 and genes involved in fatty acid oxidation in concordance with the characterized role of ERRγ in cardiac metabolism. Treatment of primary mouse myotubes with GSK4716, an ERRβ/γ agonist, results in a concerted increase in the expression levels of Ppargc1a, Ppargc1b, and the Esrr genes. Furthermore,Cpt1b, Atp5b, and Idh3, genes in key mitochondrial pathways, are also induced by GSK4716. Additionally, GSK4716 increases citrate synthase activity and cytochrome c protein levels.

相关产品：Bioactive Compound Library Plus | Anti-Cancer Compound Library | Tamoxifen | Fulvestrant | Estradiol | 4-Hydroxytamoxifen | Kaempferol | G15 | G-1 | Cholesterol | Bazedoxifene acetate | PHTPP | Raloxifene hydrochloride | DPN | Estrone | Chrysin | (-)-(S)-Equol | 27-Hydroxycholesterol | Liquiritigenin | Propyl pyrazole triol | Toremifene citrate | Genistin | Diethylstilbestrol | Saikosaponin D | Lasofoxifene Tartrate | (20S)-Protopanaxatriol | Estriol | Prinaberel | Clomiphene citrate | Kaempferide

品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。