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Wortmannin

CAS No. : 19545-26⁻⁷

MCE 国际站：Wortmannin

产品活性：Wortmannin (SL-2052) 是一种有效的，不可逆的，选择性PI3K 抑制剂，IC₅₀ 值为 3 nM。Wortmannin (SL-2052) 阻断自噬 (autophagy) 形成，并有效抑制 Polo-like kinase 1 (PlK1) 和 Plk3，IC₅₀ 值分别为 5.8 和 48 nM。

研究领域：PI3K/Akt/mTOR | Cell Cycle/DNA Damage | Autophagy | Anti-infection

作用靶点：PI3K | Polo-like Kinase (PLK) | Autophagy | Antibiotic

In Vitro: Wortmannin (0-100 nM; 24⁻⁷2 hours) inhibits the proliferation of K562 cells in a time- and dose-dependent manner. The IC₅₀ values at 24 hour, 48 hour, and 72 hour are 25±0.10 nM, 12.5±0.08 nM, and 6.25±0.11 nM, respectively. Wortmannin prevents nuclear entry of YAP.

In Vivo: Wortmannin (oral gavage; daily; in Scid mice; one group of eight mice is dosed with Wortmannin 1 mg/kg for all 14 days. The second group of eight mice is dosed with Wortmannin 1.5 mg/kg for the first 5 days and the dose is decreased to 1 mg/kg for the remaining treatment period) treatment significantly slower the growth rate of murine C3H mammary tumor and human MCF⁻⁷ breast cancer xenograft. A dose of 1 mg/kg Wortmannin for 7 days decrease the tumor burdens in mice with established murine C3H mammary tumors by 54% relative to controls. Human MCF⁻⁷ breast cancer xenograft burdens are decreased by 97% relative to controls after 14 days of 1 mg/kg Wortmannin beginning 1 day after tumor implantation.

相关产品：Covalent Screening Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Cell Cycle/DNA Damage Compound Library | Kinase Inhibitor Library | PI3K/Akt/mTOR Compound Library | Stem Cell Signaling Compound Library | Anti-Cancer Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Covalent Screening Library | Differentiation Inducing Compound Library | Oxygen Sensing Compound Library | Glycolysis Compound Library | Cytoskeleton Compound Library | Antibiotics Library | Anti-Breast Cancer Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Rapamycin | 3-Methyladenine | LY294002 | Doxorubicin hydrochloride | Bafilomycin A1 | Puromycin dihydrochloride | Cycloheximide | Chloroquine | Staurosporine | Dexamethasone | Doxycycline (hyclate) | Actinomycin D | Cyclosporin A | G-418 disulfate | 5-Azacytidine | Etoposide | Mitomycin C | Nigericin sodium salt | Brefeldin A | Resveratrol | Quercetin | Tunicamycin | Bleomycin sulfate | Hygromycin B | Tacrolimus | Ionomycin | Vancomycin hydrochloride | 740 Y-P | Streptozocin

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