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STAT5-IN-1

CAS No. : 285986-31-4

MCE 国际站：STAT5-IN-1

产品活性：STAT5-IN-1是 STAT5 的抑制剂，对 STAT5β 亚型的 IC₅₀ 值为 47 µM。

研究领域：JAK/STAT Signaling | Stem Cell/Wnt

作用靶点：STAT

In Vitro: The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins, implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 µM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members.

相关产品：Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | JAK/STAT Compound Library | Kinase Inhibitor Library | Stem Cell Signaling Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Differentiation Inducing Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Stattic | AG490 | Fludarabine | AS1517499 | Niclosamide | Artesunate | Homoharringtonine | TPCA-1 | Colivelin TFA | Cryptotanshinone | Napabucasin | Pimozide | C188-9 | Scutellarin | BP-1-102 | Cucurbitacin I | Saikosaponin D | Fraxinellone | Nifuroxazide | STAT3-IN-1 | Alantolactone | Atractylenolide I | Dihydroisotanshinone I | FLLL32 | HO-3867 | Mogrol | Diosgenin | Garcinone D | HJC0152 hydrochloride | STAT3-IN-3

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