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GSK2983559 active metabolite

CAS No. : 1423186-80-4

MCE 国际站：GSK2983559 active metabolite

产品活性：GSK2983559 active metabolite 是 GSK2983559 的活性代谢物。GSK2983559 active metabolite 是一种受体相互作用蛋白-2 (RIP2) 激酶抑制剂，详细信息请参考专利 WO/2014043446 A1 中的化合物 example 1。

研究领域：Apoptosis

作用靶点：RIP kinase

In Vitro: GSK2983559 active metabolite is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase, which is also referred to as CARD3, RICK, CARDIAK, or RIPK2, is a TKL family serine/threonine protein kinase involved in innate immune signaling. RIP2 kinase is composed of an N-terminal kinase domain and a C-terminal caspase-recruitment domain (CARD) linked via an intermediate (IM) region. The CARD domain of RIP2 kinase mediates interaction with other CARD-containing proteins, such as NODI and NOD2. NODI and NOD2 are cytoplasmic receptors which play a key role in innate immune surveillance. They recognize both gram positive and gram negative bacterial pathogens and are activated by specific peptidoglycan motifs, diaminopimelic acid (i.e., DAP) and muramyl dipeptide.

相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Kinase Inhibitor Library | NF-κB Signaling Compound Library | Anti-Cancer Compound Library | Necrostatin-1 | GSK-872 | GSK583 | GSK840 | GSK-843 | HS-1371 | RIP2 kinase inhibitor 2 | PROTAC RIPK degrader-2 | RIPK-IN-4 | RIPK1-IN-4 | RIPK1-IN⁻⁷ | PROTAC RIPK degrader-6 | Kongensin A | GNE684 | cRIPGBM

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