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Dimethylenastron

CAS No. : 863774-58⁻⁷

MCE 国际站：Dimethylenastron

产品活性：Dimethylenastron 是一种有效的驱动蛋白 Eg5 抑制剂，IC₅₀ 值为 200 nM。

研究领域：Cell Cycle/DNA Damage | Cytoskeleton

作用靶点：Kinesin

In Vitro: Dimethylenastron is a potent Eg5 inhibitor, with an IC₅₀ of 200 nM. Dimethylenastron exhibits no inhibition of five other kinesin subfamilies (kinesin 1/4/7/10 and one ungrouped-originating from 4 different organisms). Dimethylenastron (0.5, 1 µM) causes accumulation of cells in G2/M in HeLa cells. Dimethylenastron (3 and 10 µM) concentration-dependently suppresses the migratory ability of the cancer cells in PANC1 pancreatic cancer cells after treatment for 24 h, but does not inhibit the proliferation of cancer cells at 24 h until 72 h. Dimethylenastron also reduces invasion ability of the cancer cells.

In Vivo: Dimethylenastron (1.0 µmol) induces a milder scarring but the length of bleb survival is not significantly prolonged compared with the control group. Dimethylenastron (1.0 µmol) reveals a markedly reduced ratio of intraocular pressure and a milder, but not obviously reduced, subconjunctival fibrotic reaction in the rabbits treated with glaucoma filtration surgery.

相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Cytoskeleton Compound Library | Anti-Pancreatic Cancer Compound Library | Kif15-IN-1 | Monastrol | AZ82 | Paprotrain | Litronesib | SB⁻⁷43921 hydrochloride | CW-069 | PF-2771 | GW406108X | Kif15-IN-2 | Eg5 Inhibitor V, trans-24 | BRD9876

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